The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Peptide methionine sulphoxide reductase MsrA
".
FunFam 1: Peptide methionine sulfoxide reductase MsrA
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Peptide-methionine (S)-S-oxide reductase activity GO:0008113
Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.
|
92 |
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
(82 more) |
|
Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor GO:0016671
Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide.
|
91 |
P0A744 (/IMP)
P0A744 (/IMP)
P0A744 (/IMP)
P0A744 (/IMP)
P0A744 (/IMP)
P0A744 (/IMP)
P0A744 (/IMP)
P0A744 (/IMP)
P0A744 (/IMP)
P0A744 (/IMP)
(81 more) |
|
L-methionine-(S)-S-oxide reductase activity GO:0036456
Catalysis of the reaction: L-methionine (S)-S-oxide + thioredoxin -> L-methionine + thioredoxin disulfide + H2O.
|
91 |
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
(81 more) |
|
Peptide-methionine (S)-S-oxide reductase activity GO:0008113
Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.
|
7 | Q9KP30 (/ISS) Q9KP30 (/ISS) Q9KP30 (/ISS) Q9KP30 (/ISS) Q9KP30 (/ISS) Q9KP30 (/ISS) Q9KP30 (/ISS) |
|
Peptide-methionine (S)-S-oxide reductase activity GO:0008113
Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.
|
1 | Q9D6Y7 (/IMP) |
|
Peptide-methionine (S)-S-oxide reductase activity GO:0008113
Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.
|
1 | Q9D6Y7 (/ISO) |
|
Peptide-methionine (S)-S-oxide reductase activity GO:0008113
Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.
|
1 | Q9UJ68 (/TAS) |
There are 13 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
91 |
P0A744 (/IMP)
P0A744 (/IMP)
P0A744 (/IMP)
P0A744 (/IMP)
P0A744 (/IMP)
P0A744 (/IMP)
P0A744 (/IMP)
P0A744 (/IMP)
P0A744 (/IMP)
P0A744 (/IMP)
(81 more) |
|
Protein repair GO:0030091
The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues.
|
91 |
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
(81 more) |
|
Protein repair GO:0030091
The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues.
|
7 | Q9KP30 (/ISS) Q9KP30 (/ISS) Q9KP30 (/ISS) Q9KP30 (/ISS) Q9KP30 (/ISS) Q9KP30 (/ISS) Q9KP30 (/ISS) |
|
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
|
6 | Q9HUF1 (/IMP) Q9HUF1 (/IMP) Q9HUF1 (/IMP) Q9HUF1 (/IMP) Q9HUF1 (/IMP) Q9HUF1 (/IMP) |
|
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
6 | Q9HUF1 (/IMP) Q9HUF1 (/IMP) Q9HUF1 (/IMP) Q9HUF1 (/IMP) Q9HUF1 (/IMP) Q9HUF1 (/IMP) |
|
Response to hypochlorite GO:1901530
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hypochlorite stimulus.
|
6 | Q9HUF1 (/IMP) Q9HUF1 (/IMP) Q9HUF1 (/IMP) Q9HUF1 (/IMP) Q9HUF1 (/IMP) Q9HUF1 (/IMP) |
|
Cellular protein modification process GO:0006464
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
|
1 | Q9UJ68 (/TAS) |
|
Methionine metabolic process GO:0006555
The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
|
1 | Q9UJ68 (/TAS) |
|
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | Q9UJ68 (/TAS) |
|
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
|
1 | Q923M1 (/IDA) |
|
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
|
1 | Q923M1 (/IEP) |
|
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
|
1 | Q9D6Y7 (/ISO) |
|
Protein repair GO:0030091
The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues.
|
1 | Q9UJ68 (/TAS) |
There are 13 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
93 |
E5RIA9 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
P0A744 (/IDA)
(83 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | E5RIA9 (/IDA) Q9UJ68 (/IDA) |
|
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
2 | E5RIA9 (/IDA) Q9UJ68 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q9D6Y7 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q923M1 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9D6Y7 (/ISO) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q9D6Y7 (/HDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q923M1 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q9D6Y7 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9D6Y7 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9UJ68 (/TAS) |
|
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
1 | Q9D6Y7 (/ISO) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q9UJ68 (/HDA) |