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CATH Superfamily 3.20.20.70

Aldolase class I

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 23: Lipoyl synthase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 163 P60716 (/IPI) P60716 (/IPI) P60716 (/IPI) P60716 (/IPI) P60716 (/IPI) P60716 (/IPI) P60716 (/IPI) P60716 (/IPI) P60716 (/IPI) P60716 (/IPI)
(153 more)
Lipoate synthase activity GO:0016992
Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl.
 163 P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA)
(153 more)
4 iron, 4 sulfur cluster binding GO:0051539
Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
 163 P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA)
(153 more)
Lipoate synthase activity GO:0016992
Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl.
 4 Q9KTF9 (/ISS) Q9KTF9 (/ISS) Q9KTF9 (/ISS) Q9KTF9 (/ISS)

There are 3 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lipoate biosynthetic process GO:0009107
The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid.
 163 P60716 (/IMP) P60716 (/IMP) P60716 (/IMP) P60716 (/IMP) P60716 (/IMP) P60716 (/IMP) P60716 (/IMP) P60716 (/IMP) P60716 (/IMP) P60716 (/IMP)
(153 more)
Protein lipoylation GO:0009249
The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine.
 163 P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA)
(153 more)
Lipoate biosynthetic process GO:0009107
The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid.
 4 Q9KTF9 (/ISS) Q9KTF9 (/ISS) Q9KTF9 (/ISS) Q9KTF9 (/ISS)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 163 P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA)
(153 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 163 P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA) P60716 (/IDA)
(153 more)