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CATH Superfamily 3.20.20.100

NADP-dependent oxidoreductase domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NADP-dependent oxidoreductase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Aldo-keto reductase family 1 member A1

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.2]
An alcohol + NADP(+) = an aldehyde + NADPH.
  • Some members of this group oxidize only primary alcohols; others act also on secondary alcohols.
  • May be identical with EC 1.1.1.19, EC 1.1.1.33 and EC 1.1.1.55.
  • Re-specific with respect to NADPH.
 26 A0A2R9ABJ2 A0A2R9ABJ2 A0A2R9ABJ2 G3GYP7 G3GYP7 O70473 O70473 P14550 P14550 P14550
(16 more...)
Glucuronate reductase. [EC: 1.1.1.19]
L-gulonate + NADP(+) = D-glucuronate + NADPH.
  • Also reduces D-galacturonate.
  • May be identical with EC 1.1.1.2.
 21 A0A2R9ABJ2 A0A2R9ABJ2 A0A2R9ABJ2 G3GYP7 G3GYP7 O70473 O70473 P14550 P14550 P14550
(11 more...)
Allyl-alcohol dehydrogenase. [EC: 1.1.1.54]
Allyl alcohol + NADP(+) = acrolein + NADPH.
  • Also acts on saturated primary alcohols.
 21 A0A2R9ABJ2 A0A2R9ABJ2 A0A2R9ABJ2 G3GYP7 G3GYP7 O70473 O70473 P14550 P14550 P14550
(11 more...)
D/L-glyceraldehyde reductase. [EC: 1.1.1.372]
(1) Glycerol + NADP(+) = L-glyceraldehyde + NADPH. (2) Glycerol + NADP(+) = D-glyceraldehyde + NADPH.
  • The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina).
  • It has equal activity with D- and L-glyceraldehyde, and can also reduce glyoxal and methylglyoxal.
  • The reaction is only observed in the direction of glyceraldehyde reduction.
 21 A0A2R9ABJ2 A0A2R9ABJ2 A0A2R9ABJ2 G3GYP7 G3GYP7 O70473 O70473 P14550 P14550 P14550
(11 more...)
Glucuronolactone reductase. [EC: 1.1.1.20]
L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + NADPH.
    		 21 A0A2R9ABJ2 A0A2R9ABJ2 A0A2R9ABJ2 G3GYP7 G3GYP7 O70473 O70473 P14550 P14550 P14550
    (11 more...)
    Mevaldate reductase (NADPH). [EC: 1.1.1.33]
    (R)-mevalonate + NADP(+) = mevaldate + NADPH.
    • May be identical with EC 1.1.1.2.
    		 12 G3GYP7 G3GYP7 O70473 O70473 P50578 P51635 Q3ZCJ2 Q540D7 Q540D7 Q5R5D5
    (2 more...)
    Carbonyl reductase (NADPH). [EC: 1.1.1.184]
    R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
    • Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol.
    • Si-specific with respect to NADPH (cf. EC 1.1.1.2).
    		 1 P74308