The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

CRISPR-associated endonuclease Cas1, N-terminal domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: CRISPR-associated endonuclease Cas1, N-terminal domain

Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.

This superfamily entry represents the CRISPR-associated endonuclease Cas1, N-terminal beta-sandwich-like domain. Cas1 may play a role in the recognition, cleavage, and/or integration of foreign nucleic acids into CRISPRs.

PFAM:PF01867, INTERPRO:IPR002729,DOI:10.1111/j.1365-2958.2010.07465.x

GO Diversity

Unique GO annotations
7 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
4719 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 84
Domain clusters (>95% seq id): 9
Domain clusters (>35% seq id): 5
Unique PDBs: 22
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 3
Unique EC: 1
Unique GO: 7
Unique Species: 4719