The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 8: Cell death inducing DFFA like effector a

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 A4FUX1 (/ISS) O60543 (/ISS) W5NUH1 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 O70302 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 O70302 (/IDA)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Temperature homeostasis GO:0001659
A homeostatic process in which an organism modulates its internal body temperature.
3 A4FUX1 (/ISS) O60543 (/ISS) W5NUH1 (/ISS)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
3 A4FUX1 (/ISS) O60543 (/ISS) W5NUH1 (/ISS)
Cell death GO:0008219
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
3 A4FUX1 (/ISS) O60543 (/ISS) W5NUH1 (/ISS)
Positive regulation of sequestering of triglyceride GO:0010890
Any process that increases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.
3 A4FUX1 (/ISS) O60543 (/ISS) W5NUH1 (/ISS)
Lipid storage GO:0019915
The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
3 A4FUX1 (/ISS) O60543 (/ISS) W5NUH1 (/ISS)
Negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
3 A4FUX1 (/ISS) O60543 (/ISS) W5NUH1 (/ISS)
Negative regulation of lipid catabolic process GO:0050995
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.
3 A4FUX1 (/ISS) O60543 (/ISS) W5NUH1 (/ISS)
Negative regulation of execution phase of apoptosis GO:1900118
Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis.
3 A4FUX1 (/ISS) O60543 (/ISS) W5NUH1 (/ISS)
Regulation of apoptotic DNA fragmentation GO:1902510
Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation.
3 A4FUX1 (/ISS) O60543 (/ISS) W5NUH1 (/ISS)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
2 A4FUX1 (/ISS) W5NUH1 (/ISS)
Negative regulation of cytokine secretion GO:0050710
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell.
2 A4FUX1 (/ISS) W5NUH1 (/ISS)
Negative regulation of lipid catabolic process GO:0050995
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.
2 O60543 (/IMP) O70302 (/IMP)
Negative regulation of cold-induced thermogenesis GO:0120163
Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
2 D4ACH9 (/ISS) O60543 (/ISS)
Temperature homeostasis GO:0001659
A homeostatic process in which an organism modulates its internal body temperature.
1 O70302 (/IMP)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
1 O70302 (/IMP)
Cell death GO:0008219
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
1 O70302 (/IDA)
Positive regulation of sequestering of triglyceride GO:0010890
Any process that increases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.
1 O70302 (/IDA)
Lipid storage GO:0019915
The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
1 O70302 (/IMP)
Negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
1 O70302 (/IDA)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
1 O60543 (/IMP)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
1 O70302 (/ISO)
Lipid droplet organization GO:0034389
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle.
1 O60543 (/TAS)
Response to stilbenoid GO:0035634
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones.
1 O70302 (/IEP)
Negative regulation of cytokine secretion GO:0050710
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell.
1 O60543 (/IMP)
Negative regulation of cytokine secretion GO:0050710
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell.
1 O70302 (/ISO)
Negative regulation of lipid catabolic process GO:0050995
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.
1 O70302 (/ISO)
Negative regulation of cold-induced thermogenesis GO:0120163
Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
1 O70302 (/IMP)
Negative regulation of execution phase of apoptosis GO:1900118
Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis.
1 O70302 (/IDA)
Regulation of apoptotic DNA fragmentation GO:1902510
Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation.
1 O70302 (/IDA)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 A4FUX1 (/ISS) O60543 (/ISS) W5NUH1 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 A4FUX1 (/ISS) O60543 (/ISS) W5NUH1 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 A4FUX1 (/ISS) O60543 (/ISS) W5NUH1 (/ISS)
Mitochondrial envelope GO:0005740
The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.
3 A4FUX1 (/ISS) O60543 (/ISS) W5NUH1 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O70302 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O70302 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 O70302 (/IDA)
Mitochondrial envelope GO:0005740
The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.
1 O70302 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O60543 (/TAS)