The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ubiquitin Conjugating Enzyme
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 50: eIF-2-alpha kinase GCN2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Eukaryotic translation initiation factor 2alpha kinase activity GO:0004694
Catalysis of the reaction: ATP +
5 A0A0B4KHX7 (/IDA) F4J8A5 (/IDA) P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
4 F4J8A5 (/IDA) P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
4 P15442 (/IDA) P15442 (/IDA) P15442 (/IDA) Q9HGN1 (/IDA)
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
3 P15442 (/IMP) P15442 (/IMP) P15442 (/IMP)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
3 P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
3 P15442 (/IMP) P15442 (/IMP) P15442 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P15442 (/IPI) P15442 (/IPI) P15442 (/IPI)
Translation initiation factor binding GO:0031369
Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.
3 P15442 (/IPI) P15442 (/IPI) P15442 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
Ribosome binding GO:0043022
Interacting selectively and non-covalently with any part of a ribosome.
3 P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
Ribosomal large subunit binding GO:0043023
Interacting selectively and non-covalently with any part of the larger ribosomal subunit.
3 P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
3 P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
2 A1Z9I6 (/ISS) Q7K199 (/ISS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 A1Z9I6 (/ISM) Q7K199 (/ISM)
Eukaryotic translation initiation factor 2alpha kinase activity GO:0004694
Catalysis of the reaction: ATP +
1 Q9HGN1 (/IMP)
Eukaryotic translation initiation factor 2alpha kinase activity GO:0004694
Catalysis of the reaction: ATP +
1 Q4WU06 (/ISA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q9HGN1 (/ISM)

There are 59 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular response to amino acid starvation GO:0034198
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
5 P15442 (/IMP) P15442 (/IMP) P15442 (/IMP) Q4WU06 (/IMP) Q9HGN1 (/IMP)
Positive regulation of cell size GO:0045793
Any process that increases cell size.
5 A0A0B4KHX7 (/IGI) O01712 (/IGI) O61651 (/IGI) Q7YU14 (/IGI) Q9V9X8 (/IGI)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
4 A0A0B4KHX7 (/IDA) P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
DNA damage checkpoint GO:0000077
A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.
3 P15442 (/IMP) P15442 (/IMP) P15442 (/IMP)
Chronological cell aging GO:0001300
The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state.
3 P15442 (/IMP) P15442 (/IMP) P15442 (/IMP)
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
3 P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
3 P15442 (/IMP) P15442 (/IMP) P15442 (/IMP)
Positive regulation of macroautophagy GO:0016239
Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.
3 P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
Cellular response to amino acid starvation GO:0034198
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
3 P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
3 P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
3 P15442 (/IMP) P15442 (/IMP) P15442 (/IMP)
Regulation of eIF2 alpha phosphorylation by amino acid starvation GO:0060733
Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to amino acid starvation.
3 P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
Regulation of eIF2 alpha phosphorylation by amino acid starvation GO:0060733
Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to amino acid starvation.
3 P15442 (/IMP) P15442 (/IMP) P15442 (/IMP)
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
3 P15442 (/IMP) P15442 (/IMP) P15442 (/IMP)
Cellular response to histidine GO:0071232
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histidine stimulus.
3 P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
Positive regulation of translational initiation in response to starvation GO:0071264
Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment.
3 P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
Positive regulation of translational initiation in response to starvation GO:0071264
Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment.
3 P15442 (/IMP) P15442 (/IMP) P15442 (/IMP)
Cellular response to benomyl GO:0072755
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus.
3 P15442 (/IMP) P15442 (/IMP) P15442 (/IMP)
Negative regulation of protein kinase activity by protein phosphorylation GO:0100002
Any protein phosphorylation process that negatively_regulates protein kinase activity
3 P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
Positive regulation of cellular response to amino acid starvation GO:1903833
Any process that activates or increases the frequency, rate or extent of cellular response to amino acid starvation.
3 P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
Positive regulation of cellular response to amino acid starvation GO:1903833
Any process that activates or increases the frequency, rate or extent of cellular response to amino acid starvation.
3 P15442 (/IGI) P15442 (/IGI) P15442 (/IGI)
Positive regulation of cellular response to amino acid starvation GO:1903833
Any process that activates or increases the frequency, rate or extent of cellular response to amino acid starvation.
3 P15442 (/IMP) P15442 (/IMP) P15442 (/IMP)
Negative regulation of TORC1 signaling GO:1904262
Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling.
3 P15442 (/IMP) P15442 (/IMP) P15442 (/IMP)
Cellular stress response to acidic pH GO:1990451
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in the homeostasis of organismal or cellular pH (with pH < 7). pH is a measure of the acidity or basicity of an aqueous solution.
3 P15442 (/IMP) P15442 (/IMP) P15442 (/IMP)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
2 A1Z9I6 (/ISS) Q7K199 (/ISS)
Cellular response to amino acid starvation GO:0034198
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
2 Q9HGN1 (/ISS) Q9LX30 (/ISS)
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
2 Q9HGN1 (/ISS) Q9LX30 (/ISS)
Cellular response to benomyl GO:0072755
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus.
2 Q9HGN1 (/ISS) Q9LX30 (/ISS)
Cellular stress response to acidic pH GO:1990451
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in the homeostasis of organismal or cellular pH (with pH < 7). pH is a measure of the acidity or basicity of an aqueous solution.
2 Q9HGN1 (/ISS) Q9LX30 (/ISS)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 D0Z5N4 (/IMP)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 D0Z5N4 (/IGI)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 D0Z5N4 (/IMP)
Regulation of cellular amino acid metabolic process GO:0006521
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids.
1 F4J8A5 (/IGI)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 D0Z5N4 (/IGI)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
1 D0Z5N4 (/IMP)
Response to UV GO:0009411
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
1 D0Z5N4 (/IMP)
Response to herbicide GO:0009635
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants.
1 F4J8A5 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 D0Z5N4 (/IGI)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 D0Z5N4 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 D0Z5N4 (/IGI)
Regulation of translational initiation by eIF2 alpha phosphorylation GO:0010998
Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha.
1 A0A0B4KHX7 (/IC)
Regulation of translational initiation by eIF2 alpha phosphorylation GO:0010998
Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha.
1 A0A0B4KHX7 (/IDA)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
1 F4J8A5 (/IDA)
Cellular homeostasis GO:0019725
Any process involved in the maintenance of an internal steady state at the level of the cell.
1 D0Z5N4 (/IMP)
Mitotic G1 DNA damage checkpoint GO:0031571
A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G1/S transition of the cell cycle in response to DNA damage.
1 Q9HGN1 (/IMP)
Stress granule assembly GO:0034063
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
1 D0Z5N4 (/IMP)
Mitochondrial unfolded protein response GO:0034514
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the mitochondrial matrix; results in transcriptional upregulation of nuclear genes encoding mitochondrial stress proteins.
1 D0Z5N4 (/IMP)
Response to starvation GO:0042594
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
1 D0Z5N4 (/IMP)
Regulation of brood size GO:0060378
Any process that modulates brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time.
1 D0Z5N4 (/IGI)
Positive regulation of nematode larval development GO:0061063
Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
1 D0Z5N4 (/IGI)
Positive regulation of nematode larval development GO:0061063
Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
1 D0Z5N4 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter in response to increased salt GO:0061404
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 D0Z5N4 (/IMP)
G1 cell cycle arrest in response to nitrogen starvation GO:0071849
The process in which the cell cycle is halted during G1 phase, as a result of deprivation of nitrogen.
1 Q9HGN1 (/IMP)
Signal transduction involved in mitotic G1 DNA damage checkpoint GO:0072431
A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint.
1 Q9HGN1 (/IMP)
Response to sodium arsenite GO:1903935
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus.
1 D0Z5N4 (/IGI)
Regulation of translation involved in cellular response to UV GO:1904803
Any regulation of translation that is involved in cellular response to UV.
1 Q9HGN1 (/IMP)
Positive regulation of protein oxidation GO:1904808
Any process that activates or increases the frequency, rate or extent of protein oxidation.
1 D0Z5N4 (/IGI)
Negative regulation of cytoplasmic translational initiation in response to stress GO:1990625
Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress.
1 Q9HGN1 (/IDA)
Negative regulation of cytoplasmic translational initiation in response to stress GO:1990625
Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress.
1 Q9HGN1 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Large ribosomal subunit GO:0015934
The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site).
3 P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
Small ribosomal subunit GO:0015935
The smaller of the two subunits of a ribosome.
3 P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
Cytosolic ribosome GO:0022626
A ribosome located in the cytosol.
3 P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
Polysomal ribosome GO:0042788
A ribosome bound to mRNA that forms part of a polysome.
3 P15442 (/IDA) P15442 (/IDA) P15442 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 A0A0B4KHX7 (/IC)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9HGN1 (/ISO)