The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Mannose-Binding Protein A, subunit A
".
FunFam 62: C-type lectin domain family 2 member D
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
8 | Q07108 (/IPI) Q07108 (/IPI) Q6UVW9 (/IPI) Q91V08 (/IPI) Q91V08 (/IPI) Q91V08 (/IPI) Q9WVF9 (/IPI) Q9WVF9 (/IPI) |
|
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
|
6 | Q8C1T8 (/ISS) Q91V08 (/ISS) Q91V08 (/ISS) Q91V08 (/ISS) Q9WVF9 (/ISS) Q9WVF9 (/ISS) |
|
Carbohydrate binding GO:0030246
Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
|
6 | Q8C1T8 (/ISS) Q91V08 (/ISS) Q91V08 (/ISS) Q91V08 (/ISS) Q9WVF9 (/ISS) Q9WVF9 (/ISS) |
|
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
|
5 | Q07108 (/TAS) Q07108 (/TAS) Q9UHP7 (/TAS) Q9UHP7 (/TAS) Q9UHP7 (/TAS) |
|
Natural killer cell lectin-like receptor binding GO:0046703
Interacting selectively and non-covalently with a lectin-like natural killer cell receptor.
|
5 | Q91V08 (/IDA) Q91V08 (/IDA) Q91V08 (/IDA) Q9WVF9 (/IDA) Q9WVF9 (/IDA) |
|
Natural killer cell lectin-like receptor binding GO:0046703
Interacting selectively and non-covalently with a lectin-like natural killer cell receptor.
|
4 | Q8C1T8 (/IPI) Q9D676 (/IPI) Q9WVF9 (/IPI) Q9WVF9 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
3 | P37217 (/ISO) P37217 (/ISO) Q8VI21 (/ISO) |
|
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
2 | P37217 (/ISO) P37217 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | Q07108 (/IMP) Q07108 (/IMP) |
|
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
1 | Q5M851 (/IDA) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q6UVW9 (/IDA) |
There are 17 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cellular defense response GO:0006968
A defense response that is mediated by cells.
|
4 | Q8C1T8 (/TAS) Q91V08 (/TAS) Q91V08 (/TAS) Q91V08 (/TAS) |
|
Negative regulation of osteoclast differentiation GO:0045671
Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation.
|
4 | Q91V08 (/IDA) Q91V08 (/IDA) Q91V08 (/IDA) Q9D676 (/IDA) |
|
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
3 | Q9UHP7 (/TAS) Q9UHP7 (/TAS) Q9UHP7 (/TAS) |
|
Protection from natural killer cell mediated cytotoxicity GO:0042270
The process of protecting a cell from natural killer cell mediated cytotoxicity.
|
3 | Q91V08 (/IDA) Q91V08 (/IDA) Q91V08 (/IDA) |
|
Protection from natural killer cell mediated cytotoxicity GO:0042270
The process of protecting a cell from natural killer cell mediated cytotoxicity.
|
3 | Q91V08 (/IGI) Q91V08 (/IGI) Q91V08 (/IGI) |
|
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
|
3 | Q9UHP7 (/TAS) Q9UHP7 (/TAS) Q9UHP7 (/TAS) |
|
Membrane raft assembly GO:0001765
The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes.
|
2 | Q9WVF9 (/NAS) Q9WVF9 (/NAS) |
|
Regulation of actin filament polymerization GO:0030833
Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.
|
2 | Q9WVF9 (/IMP) Q9WVF9 (/IMP) |
|
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
2 | P37217 (/IEP) P37217 (/IEP) |
|
Regulation of T cell proliferation GO:0042129
Any process that modulates the frequency, rate or extent of T cell proliferation.
|
2 | Q9WVF9 (/IMP) Q9WVF9 (/IMP) |
|
Receptor clustering GO:0043113
The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
|
2 | Q9WVF9 (/IMP) Q9WVF9 (/IMP) |
|
Regulation of interleukin-2 biosynthetic process GO:0045076
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.
|
2 | Q9WVF9 (/IMP) Q9WVF9 (/IMP) |
|
Negative regulation of osteoclast differentiation GO:0045671
Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation.
|
2 | Q9WVF9 (/NAS) Q9WVF9 (/NAS) |
|
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
|
2 | Q9WVF9 (/IMP) Q9WVF9 (/IMP) |
|
Positive regulation of immunological synapse formation GO:2000522
Any process that activates or increases the frequency, rate or extent of immunological synapse formation.
|
2 | Q9WVF9 (/NAS) Q9WVF9 (/NAS) |
|
Complement activation, lectin pathway GO:0001867
Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
|
1 | Q5M851 (/TAS) |
|
Natural killer cell mediated cytotoxicity GO:0042267
The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
|
1 | Q6UVW9 (/TAS) |
There are 11 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
9 | Q07108 (/TAS) Q07108 (/TAS) Q8C1T8 (/TAS) Q91V08 (/TAS) Q91V08 (/TAS) Q91V08 (/TAS) Q9UHP7 (/TAS) Q9UHP7 (/TAS) Q9UHP7 (/TAS) |
|
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
7 | P37217 (/IDA) P37217 (/IDA) Q91V08 (/IDA) Q91V08 (/IDA) Q91V08 (/IDA) Q9WVF9 (/IDA) Q9WVF9 (/IDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
7 | P37217 (/IDA) P37217 (/IDA) Q9UHP7 (/IDA) Q9UHP7 (/IDA) Q9UHP7 (/IDA) Q9WVF9 (/IDA) Q9WVF9 (/IDA) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
3 | Q9UHP7 (/IDA) Q9UHP7 (/IDA) Q9UHP7 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | Q9UHP7 (/TAS) Q9UHP7 (/TAS) Q9UHP7 (/TAS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
3 | Q9UHP7 (/TAS) Q9UHP7 (/TAS) Q9UHP7 (/TAS) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
2 | Q07108 (/IMP) Q07108 (/IMP) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
2 | P37217 (/ISO) P37217 (/ISO) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | Q9D676 (/IC) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q6UVW9 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q8VI21 (/ISO) |