The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cupredoxins - blue copper proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 20: Ephrin-B2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 A0A0B5JFB4 (/IPI) P52799 (/IPI) P52799 (/IPI) P52799 (/IPI) P52800 (/IPI) P52800 (/IPI)
Ephrin receptor binding GO:0046875
Interacting selectively and non-covalently with an ephrin receptor.
3 P52799 (/IPI) P52799 (/IPI) P52799 (/IPI)
Ephrin receptor binding GO:0046875
Interacting selectively and non-covalently with an ephrin receptor.
3 P52799 (/TAS) P52799 (/TAS) P52799 (/TAS)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 P52800 (/IPI) P52800 (/IPI)
Ephrin receptor binding GO:0046875
Interacting selectively and non-covalently with an ephrin receptor.
2 P52800 (/ISO) P52800 (/ISO)

There are 50 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell migration involved in sprouting angiogenesis GO:0002042
The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
5 O73874 (/ISS) O73874 (/ISS) O73874 (/ISS) P52800 (/ISS) P52800 (/ISS)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
5 O73874 (/ISS) O73874 (/ISS) O73874 (/ISS) P52800 (/ISS) P52800 (/ISS)
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
5 O73874 (/ISS) O73874 (/ISS) O73874 (/ISS) P52800 (/ISS) P52800 (/ISS)
Regulation of chemotaxis GO:0050920
Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
5 O73874 (/ISS) O73874 (/ISS) O73874 (/ISS) P52800 (/ISS) P52800 (/ISS)
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
4 O73874 (/IGI) O73874 (/IGI) O73874 (/IGI) Q90Z32 (/IGI)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
3 O73874 (/IGI) O73874 (/IGI) O73874 (/IGI)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
3 O73874 (/IMP) O73874 (/IMP) O73874 (/IMP)
Cell migration involved in sprouting angiogenesis GO:0002042
The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
3 P52799 (/IDA) P52799 (/IDA) P52799 (/IDA)
Optic vesicle morphogenesis GO:0003404
The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.
3 O73874 (/IGI) O73874 (/IGI) O73874 (/IGI)
Optic vesicle morphogenesis GO:0003404
The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.
3 O73874 (/IMP) O73874 (/IMP) O73874 (/IMP)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
3 P52799 (/IDA) P52799 (/IDA) P52799 (/IDA)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
3 P52799 (/TAS) P52799 (/TAS) P52799 (/TAS)
Axon target recognition GO:0007412
The process in which an axon recognizes and binds to a set of cells with which it may form stable connections.
3 O73874 (/IDA) O73874 (/IDA) O73874 (/IDA)
Axon target recognition GO:0007412
The process in which an axon recognizes and binds to a set of cells with which it may form stable connections.
3 O73874 (/IMP) O73874 (/IMP) O73874 (/IMP)
Synaptic target recognition GO:0008039
The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses.
3 O73874 (/IEP) O73874 (/IEP) O73874 (/IEP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
3 P52799 (/IMP) P52799 (/IMP) P52799 (/IMP)
Anatomical structure morphogenesis GO:0009653
The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
3 P52799 (/TAS) P52799 (/TAS) P52799 (/TAS)
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
3 O73874 (/IGI) O73874 (/IGI) O73874 (/IGI)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
3 P52799 (/IDA) P52799 (/IDA) P52799 (/IDA)
Rhombomere boundary formation GO:0021654
The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
3 O73874 (/IGI) O73874 (/IGI) O73874 (/IGI)
Angioblast cell migration involved in selective angioblast sprouting GO:0035475
The directional migration of angioblast cells as part of selective angioblast sprouting, which results in angioblast segregation into arterial and venous populations.
3 O73874 (/IMP) O73874 (/IMP) O73874 (/IMP)
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
3 P52799 (/IDA) P52799 (/IDA) P52799 (/IDA)
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
3 P52799 (/TAS) P52799 (/TAS) P52799 (/TAS)
Regulation of chemotaxis GO:0050920
Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
3 P52799 (/IDA) P52799 (/IDA) P52799 (/IDA)
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
3 P52799 (/IDA) P52799 (/IDA) P52799 (/IDA)
Positive regulation of cardiac muscle cell differentiation GO:2000727
Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation.
3 P52799 (/ISS) P52799 (/ISS) P52799 (/ISS)
Lymph vessel development GO:0001945
The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.
2 P52800 (/IMP) P52800 (/IMP)
Cell migration involved in sprouting angiogenesis GO:0002042
The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
2 P52800 (/ISO) P52800 (/ISO)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
2 P52800 (/ISO) P52800 (/ISO)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 P52800 (/ISO) P52800 (/ISO)
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
2 P52800 (/IMP) P52800 (/IMP)
Negative regulation of keratinocyte proliferation GO:0010839
Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.
2 P52800 (/IMP) P52800 (/IMP)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
2 P52800 (/ISO) P52800 (/ISO)
T cell costimulation GO:0031295
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.
2 P52800 (/IDA) P52800 (/IDA)
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
2 P52800 (/ISO) P52800 (/ISO)
Blood vessel morphogenesis GO:0048514
The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
2 P52800 (/IMP) P52800 (/IMP)
Venous blood vessel morphogenesis GO:0048845
The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart.
2 P52800 (/IMP) P52800 (/IMP)
Regulation of chemotaxis GO:0050920
Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
2 P52800 (/ISO) P52800 (/ISO)
Nephric duct morphogenesis GO:0072178
The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney.
2 P52800 (/IMP) P52800 (/IMP)
Presynapse assembly GO:0099054
The aggregation, arrangement and bonding together of a set of components to form a presynapse.
2 P52800 (/ISO) P52800 (/ISO)
Regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072
Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane.
2 P52800 (/IDA) P52800 (/IDA)
Regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072
Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane.
2 P52800 (/IMP) P52800 (/IMP)
Regulation of postsynaptic neurotransmitter receptor internalization GO:0099149
Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
2 P52800 (/IDA) P52800 (/IDA)
Regulation of postsynaptic neurotransmitter receptor internalization GO:0099149
Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
2 P52800 (/IMP) P52800 (/IMP)
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
2 P52800 (/ISO) P52800 (/ISO)
Positive regulation of aorta morphogenesis GO:1903849
Any process that activates or increases the frequency, rate or extent of aorta morphogenesis.
2 P52800 (/IMP) P52800 (/IMP)
Positive regulation of cardiac muscle cell differentiation GO:2000727
Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation.
2 P52800 (/IMP) P52800 (/IMP)
Kupffer's vesicle development GO:0070121
The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period.
1 Q90Z32 (/IMP)
Presynapse assembly GO:0099054
The aggregation, arrangement and bonding together of a set of components to form a presynapse.
1 B2B9A9 (/IDA)
Presynapse assembly GO:0099054
The aggregation, arrangement and bonding together of a set of components to form a presynapse.
1 B2B9A9 (/IMP)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P52799 (/IDA) P52799 (/IDA) P52799 (/IDA) P52800 (/IDA) P52800 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P52799 (/TAS) P52799 (/TAS) P52799 (/TAS) P52800 (/TAS) P52800 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 O73874 (/ISS) O73874 (/ISS) O73874 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 P52799 (/TAS) P52799 (/TAS) P52799 (/TAS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
3 P52799 (/HDA) P52799 (/HDA) P52799 (/HDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
3 B2B9A9 (/IDA) P52800 (/IDA) P52800 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
3 B2B9A9 (/IMP) P52800 (/IMP) P52800 (/IMP)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P52800 (/ISO) P52800 (/ISO)
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
2 P52800 (/IDA) P52800 (/IDA)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
2 P52800 (/IDA) P52800 (/IDA)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
2 P52800 (/IMP) P52800 (/IMP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
2 P52800 (/ISO) P52800 (/ISO)
Integral component of presynaptic membrane GO:0099056
The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P52800 (/ISO) P52800 (/ISO)
Integral component of postsynaptic density membrane GO:0099061
The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P52800 (/IDA) P52800 (/IDA)
Integral component of presynaptic membrane GO:0099056
The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 B2B9A9 (/IDA)