The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cupredoxins - blue copper proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Cytochrome c oxidase subunit 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 O21042 (/IPI) P00403 (/IPI) P00403 (/IPI) P00410 (/IPI) P00410 (/IPI) P00410 (/IPI) P00410 (/IPI)
Cytochrome-c oxidase activity GO:0004129
Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
4 P00403 (/NAS) P00403 (/NAS) P24894 (/NAS) P24894 (/NAS)
Cytochrome-c oxidase activity GO:0004129
Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
3 Q8E8Q5 (/ISS) Q9B8D8 (/ISS) Q9B8D8 (/ISS)
Cytochrome-c oxidase activity GO:0004129
Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
1 P21534 (/IMP)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of hydrogen peroxide biosynthetic process GO:0010729
Any process that increases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
12 P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO)
(2 more)
Positive regulation of necrotic cell death GO:0010940
Any process that increases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents.
12 P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO)
(2 more)
Positive regulation of ATP biosynthetic process GO:2001171
Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process.
12 P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO)
(2 more)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
9 P18944 (/IEP) P18944 (/IEP) P18944 (/IEP) P18944 (/IEP) P18944 (/IEP) P18944 (/IEP) P18944 (/IEP) P18944 (/IEP) P18944 (/IEP)
Respiratory electron transport chain GO:0022904
A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
9 P18944 (/NAS) P18944 (/NAS) P18944 (/NAS) P18944 (/NAS) P18944 (/NAS) P18944 (/NAS) P18944 (/NAS) P18944 (/NAS) P18944 (/NAS)
Positive regulation of vasoconstriction GO:0045907
Any process that activates or increases the frequency, rate or extent of vasoconstriction.
9 Q69GF7 (/IMP) Q69GF7 (/IMP) Q69GF7 (/IMP) Q69GF7 (/IMP) Q69GF7 (/IMP) Q69GF7 (/IMP) Q69GF7 (/IMP) Q9G1G3 (/IMP) Q9G1G3 (/IMP)
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
5 P00406 (/IEP) P00406 (/IEP) P00406 (/IEP) P00406 (/IEP) P00406 (/IEP)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
5 P00406 (/IEP) P00406 (/IEP) P00406 (/IEP) P00406 (/IEP) P00406 (/IEP)
Positive regulation of hydrogen peroxide biosynthetic process GO:0010729
Any process that increases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
5 P00406 (/IMP) P00406 (/IMP) P00406 (/IMP) P00406 (/IMP) P00406 (/IMP)
Positive regulation of necrotic cell death GO:0010940
Any process that increases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents.
5 P00406 (/IMP) P00406 (/IMP) P00406 (/IMP) P00406 (/IMP) P00406 (/IMP)
Positive regulation of ATP biosynthetic process GO:2001171
Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process.
5 P00406 (/IMP) P00406 (/IMP) P00406 (/IMP) P00406 (/IMP) P00406 (/IMP)
Mitochondrial electron transport, cytochrome c to oxygen GO:0006123
The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV.
4 P00410 (/IDA) P00410 (/IDA) P00410 (/IDA) P00410 (/IDA)
Mitochondrial electron transport, cytochrome c to oxygen GO:0006123
The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV.
4 P00403 (/NAS) P00403 (/NAS) P24894 (/NAS) P24894 (/NAS)
Aerobic respiration GO:0009060
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
4 P00410 (/IMP) P00410 (/IMP) P00410 (/IMP) P00410 (/IMP)
Mitochondrial electron transport, cytochrome c to oxygen GO:0006123
The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV.
2 Q9B8D8 (/ISS) Q9B8D8 (/ISS)
Mitochondrial electron transport, cytochrome c to oxygen GO:0006123
The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV.
2 P00403 (/TAS) P00403 (/TAS)
Mitochondrial electron transport, cytochrome c to oxygen GO:0006123
The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV.
1 P21534 (/IMP)
Mitochondrial electron transport, cytochrome c to oxygen GO:0006123
The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV.
1 H9D0Q0 (/ISO)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Respiratory chain complex IV GO:0045277
A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).
596 O03848 (/ISS) O03851 (/ISS) O03889 (/ISS) O03890 (/ISS) O03891 (/ISS) O03892 (/ISS) O03893 (/ISS) O03895 (/ISS) O21400 (/ISS) O47667 (/ISS)
(586 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
34 P04373 (/ISS) P11948 (/ISS) P25312 (/ISS) P26455 (/ISS) P26455 (/ISS) P68297 (/ISS) P68297 (/ISS) P68297 (/ISS) P68297 (/ISS) P68297 (/ISS)
(24 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
23 P00403 (/IDA) P00403 (/IDA) P00405 (/IDA) P00405 (/IDA) P00405 (/IDA) P00405 (/IDA) P00405 (/IDA) P00405 (/IDA) P00405 (/IDA) P00405 (/IDA)
(13 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
16 P00405 (/HDA) P00405 (/HDA) P00405 (/HDA) P00405 (/HDA) P00405 (/HDA) P00405 (/HDA) P00405 (/HDA) P00405 (/HDA) P00405 (/HDA) P00405 (/HDA)
(6 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
12 P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO)
(2 more)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
12 P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO)
(2 more)
Respiratory chain complex IV GO:0045277
A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).
12 P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO) P00405 (/ISO)
(2 more)
Respiratory chain complex IV GO:0045277
A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).
10 P00403 (/IDA) P00403 (/IDA) P68530 (/IDA) P68530 (/IDA) P68530 (/IDA) P68530 (/IDA) P68530 (/IDA) P68530 (/IDA) P68530 (/IDA) P68530 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
9 P18944 (/TAS) P18944 (/TAS) P18944 (/TAS) P18944 (/TAS) P18944 (/TAS) P18944 (/TAS) P18944 (/TAS) P18944 (/TAS) P18944 (/TAS)
Mitochondrial respiratory chain complex IV GO:0005751
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).
4 P00410 (/IDA) P00410 (/IDA) P00410 (/IDA) P00410 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
3 P00403 (/IDA) P00403 (/IDA) P21534 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
2 P24894 (/NAS) P24894 (/NAS)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
2 P00403 (/TAS) P00403 (/TAS)
Mitochondrial respiratory chain complex IV GO:0005751
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).
2 H9D0Q0 (/ISO) P21534 (/ISO)
Mitochondrial respiratory chain complex IV GO:0005751
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).
2 Q9B8D8 (/ISS) Q9B8D8 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P00403 (/HDA) P00403 (/HDA)
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
1 P21534 (/IDA)