The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"C2 domain
".
FunFam 58: Phosphoinositide phospholipase C
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 13 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | F1Q5G9 (/IPI) F1Q876 (/IPI) F1QJ13 (/IPI) P10688 (/IPI) |
Phosphatidylinositol phospholipase C activity GO:0004435
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
|
2 | P10688 (/IDA) Q62711 (/IDA) |
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
2 | F1Q5G9 (/IDA) F1Q876 (/IDA) |
GTPase regulator activity GO:0030695
Modulates the rate of GTP hydrolysis by a GTPase.
|
2 | F1Q5G9 (/IDA) F1Q876 (/IDA) |
GTPase binding GO:0051020
Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP.
|
2 | F1Q5G9 (/IPI) F1Q876 (/IPI) |
Phosphatidylinositol phospholipase C activity GO:0004435
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
|
1 | Q8K3R3 (/ISO) |
Phospholipase C activity GO:0004629
Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.
|
1 | Q8K3R3 (/TAS) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
1 | P10688 (/IDA) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
1 | P10688 (/IMP) |
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
|
1 | P10688 (/IDA) |
Calcium-dependent phospholipid binding GO:0005544
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
|
1 | P10688 (/IMP) |
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
|
1 | P10688 (/IDA) |
Inositol 1,4,5 trisphosphate binding GO:0070679
Interacting selectively and non-covalently with inositol 1,4,5 trisphosphate.
|
1 | P10688 (/IMP) |
There are 23 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Wnt signaling pathway, calcium modulating pathway GO:0007223
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).
|
2 | F1Q5G9 (/IGI) F1Q876 (/IGI) |
Inositol phosphate metabolic process GO:0043647
The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
|
2 | Q8N3E9 (/TAS) Q9BRC7 (/TAS) |
Regulation of convergent extension involved in axis elongation GO:1901232
Any process that modulates the frequency, rate or extent of convergent extension involved in axis elongation.
|
2 | F1Q5G9 (/IGI) F1Q876 (/IGI) |
Positive regulation of epiboly involved in gastrulation with mouth forming second GO:1904088
Any process that activates or increases the frequency, rate or extent of epiboly involved in gastrulation with mouth forming second.
|
2 | F1Q5G9 (/IGI) F1Q876 (/IGI) |
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
1 | Q8K2J0 (/IGI) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
1 | Q8K3R3 (/TAS) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
1 | P10688 (/IDA) |
Acrosome reaction GO:0007340
The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.
|
1 | Q8K3R3 (/IMP) |
Response to aluminum ion GO:0010044
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus.
|
1 | P10688 (/IEP) |
Response to organonitrogen compound GO:0010243
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
|
1 | P10688 (/IEP) |
Positive regulation of norepinephrine secretion GO:0010701
Any process that increases the frequency, rate or extent of the regulated release of norepinephrine.
|
1 | P10688 (/IMP) |
Positive regulation of inositol trisphosphate biosynthetic process GO:0032962
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate.
|
1 | P10688 (/IMP) |
Response to prostaglandin F GO:0034696
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus.
|
1 | P10688 (/IEP) |
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
1 | Q62711 (/TAS) |
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
|
1 | Q8K2J0 (/IGI) |
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
|
1 | P10688 (/IMP) |
Phosphatidylinositol metabolic process GO:0046488
The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
|
1 | Q8K3R3 (/TAS) |
Regulation of cytosolic calcium ion concentration GO:0051480
Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.
|
1 | P10688 (/IMP) |
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482
Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G protein-coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol.
|
1 | P10688 (/IMP) |
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
|
1 | P10688 (/IMP) |
Response to hyperoxia GO:0055093
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.
|
1 | P10688 (/IEP) |
Labyrinthine layer blood vessel development GO:0060716
The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply.
|
1 | Q8K2J0 (/IGI) |
Regulation of phospholipase C activity GO:1900274
Any process that modulates the frequency, rate or extent of phospholipase C activity.
|
1 | P10688 (/IMP) |
There are 14 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | C9JEA7 (/IDA) D4A978 (/IDA) P10688 (/IDA) Q9BRC7 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q8K2J0 (/ISO) Q8K3R3 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | C9JEA7 (/IDA) Q9BRC7 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | D4A978 (/IDA) P10688 (/IDA) |
Extrinsic component of plasma membrane GO:0019897
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
2 | F1Q5G9 (/IDA) F1Q876 (/IDA) |
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
2 | C9JEA7 (/IDA) Q9BRC7 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P10688 (/IDA) |
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
1 | Q9BRC7 (/TAS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q8K3R3 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q8N3E9 (/TAS) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q8K2J0 (/ISO) |
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
1 | Q8K3R3 (/ISO) |
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
|
1 | P10688 (/IDA) |
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
1 | P10688 (/IDA) |