The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
C2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Protein unc-13 homolog B

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 31 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
9 H9XVP2 (/TAS) O96959 (/TAS) O96960 (/TAS) Q8IM86 (/TAS) Q8IM87 (/TAS) Q8T049 (/TAS) Q9U4K9 (/TAS) Q9V483 (/TAS) X2J9E1 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 O14795 (/IPI) Q4KUS2 (/IPI) Q62768 (/IPI) Q62769 (/IPI)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
3 Q62768 (/IDA) Q62769 (/IDA) Q62770 (/IDA)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
3 Q4KUS2 (/ISO) Q8K0T7 (/ISO) Q9Z1N9 (/ISO)
Syntaxin-1 binding GO:0017075
Interacting selectively and non-covalently with the SNAP receptor syntaxin-1.
3 Q62768 (/IDA) Q62769 (/IDA) Q62770 (/IDA)
Syntaxin-1 binding GO:0017075
Interacting selectively and non-covalently with the SNAP receptor syntaxin-1.
3 Q4KUS2 (/ISO) Q8K0T7 (/ISO) Q9Z1N9 (/ISO)
Syntaxin-1 binding GO:0017075
Interacting selectively and non-covalently with the SNAP receptor syntaxin-1.
3 H9XVP2 (/ISS) Q4KUS2 (/ISS) Q9UPW8 (/ISS)
Syntaxin binding GO:0019905
Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.
3 Q62768 (/IDA) Q62769 (/IDA) Q62770 (/IDA)
Syntaxin binding GO:0019905
Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.
3 Q4KUS2 (/ISO) Q8K0T7 (/ISO) Q9Z1N9 (/ISO)
Non-kinase phorbol ester receptor activity GO:0001566
Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity.
2 Q8K0T7 (/TAS) Q9Z1N9 (/TAS)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
2 O14795 (/ISS) Q9UPW8 (/ISS)
SNARE binding GO:0000149
Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
1 Q62768 (/IDA)
SNARE binding GO:0000149
Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
1 Q4KUS2 (/ISO)
Syntaxin-1 binding GO:0017075
Interacting selectively and non-covalently with the SNAP receptor syntaxin-1.
1 Q62768 (/IPI)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
1 O14795 (/NAS)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 Q62768 (/IDA)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 Q4KUS2 (/ISO)
Diacylglycerol binding GO:0019992
Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids.
1 Q4KUS2 (/IDA)
Diacylglycerol binding GO:0019992
Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids.
1 O14795 (/NAS)
Spectrin binding GO:0030507
Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.
1 Q62768 (/IPI)
Spectrin binding GO:0030507
Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.
1 Q4KUS2 (/ISO)
GTP-dependent protein binding GO:0030742
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) when at least one of the interacting partners is in the GTP-bound state.
1 O14795 (/IPI)
GTP-dependent protein binding GO:0030742
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) when at least one of the interacting partners is in the GTP-bound state.
1 Q9Z1N9 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q62768 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q4KUS2 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q62768 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q4KUS2 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q62768 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q4KUS2 (/ISO)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 Q62768 (/IPI)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 Q4KUS2 (/ISO)

There are 69 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Synaptic vesicle exocytosis GO:0016079
Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
13 H9XVP2 (/IMP) O96959 (/IMP) O96960 (/IMP) P27715 (/IMP) Q4KUS2 (/IMP) Q8IM86 (/IMP) Q8IM87 (/IMP) Q8K0T7 (/IMP) Q8T049 (/IMP) Q9U4K9 (/IMP)
(3 more)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
11 H9XVP2 (/IMP) O96959 (/IMP) O96960 (/IMP) Q8IM86 (/IMP) Q8IM87 (/IMP) Q8K0T7 (/IMP) Q8T049 (/IMP) Q9U4K9 (/IMP) Q9V483 (/IMP) Q9Z1N9 (/IMP)
(1 more)
Synaptic vesicle priming GO:0016082
A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.
10 H9XVP2 (/NAS) O96959 (/NAS) O96960 (/NAS) Q4KUS2 (/NAS) Q8IM86 (/NAS) Q8IM87 (/NAS) Q8T049 (/NAS) Q9U4K9 (/NAS) Q9V483 (/NAS) X2J9E1 (/NAS)
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
9 H9XVP2 (/NAS) O96959 (/NAS) O96960 (/NAS) Q8IM86 (/NAS) Q8IM87 (/NAS) Q8T049 (/NAS) Q9U4K9 (/NAS) Q9V483 (/NAS) X2J9E1 (/NAS)
Synaptic vesicle exocytosis GO:0016079
Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
9 H9XVP2 (/ISS) O96959 (/ISS) O96960 (/ISS) Q8IM86 (/ISS) Q8IM87 (/ISS) Q8T049 (/ISS) Q9U4K9 (/ISS) Q9V483 (/ISS) X2J9E1 (/ISS)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
4 O14795 (/ISS) Q62769 (/ISS) Q62770 (/ISS) Q8NB66 (/ISS)
Synaptic vesicle priming GO:0016082
A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.
4 Q4KUS2 (/IMP) Q62769 (/IMP) Q62770 (/IMP) Q9Z1N9 (/IMP)
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
3 H9XVP2 (/ISS) Q4KUS2 (/ISS) Q9UPW8 (/ISS)
Synaptic vesicle priming GO:0016082
A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.
3 Q4KUS2 (/ISO) Q8K0T7 (/ISO) Q9Z1N9 (/ISO)
Neuromuscular junction development GO:0007528
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
2 Q4KUS2 (/IGI) Q9Z1N9 (/IGI)
Positive regulation of synaptic vesicle priming GO:0010808
Any process that increases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion.
2 O14795 (/ISS) Q9Z1N9 (/ISS)
Synaptic vesicle exocytosis GO:0016079
Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
2 Q4KUS2 (/IDA) Q9Z1N9 (/IDA)
Synaptic vesicle docking GO:0016081
The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process.
2 Q4KUS2 (/IGI) Q9Z1N9 (/IGI)
Synaptic vesicle priming GO:0016082
A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.
2 Q4KUS2 (/IGI) Q9Z1N9 (/IGI)
Synaptic vesicle priming GO:0016082
A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.
2 O14795 (/ISS) Q62769 (/ISS)
Negative regulation of synaptic plasticity GO:0031914
A process that decreases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
2 Q8K0T7 (/IGI) Q9Z1N9 (/IGI)
Synaptic transmission, glutamatergic GO:0035249
The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2 Q4KUS2 (/IGI) Q9Z1N9 (/IGI)
Synaptic transmission, glutamatergic GO:0035249
The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2 Q4KUS2 (/IMP) Q9Z1N9 (/IMP)
Regulation of pharyngeal pumping GO:0043051
Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes.
2 G5EDN9 (/IGI) P27715 (/IGI)
Regulation of pharyngeal pumping GO:0043051
Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes.
2 G5EDN9 (/IMP) P27715 (/IMP)
Regulation of oviposition GO:0046662
Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium.
2 G5EDN9 (/IGI) P27715 (/IGI)
Regulation of oviposition GO:0046662
Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium.
2 G5EDN9 (/IMP) P27715 (/IMP)
Regulation of short-term neuronal synaptic plasticity GO:0048172
A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
2 Q4KUS2 (/IMP) Q9Z1N9 (/IMP)
Innervation GO:0060384
The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue.
2 Q4KUS2 (/IGI) Q9Z1N9 (/IGI)
Dense core granule priming GO:0061789
A process that converts unprimed dense core granules (DCVs) to a pool of primed vesicles that are capable of fusing with the plasma membrane (fusion-competent) and thereby releasing their contents. Priming typically occurs after docking.
2 Q62768 (/IGI) Q62769 (/IGI)
Dense core granule priming GO:0061789
A process that converts unprimed dense core granules (DCVs) to a pool of primed vesicles that are capable of fusing with the plasma membrane (fusion-competent) and thereby releasing their contents. Priming typically occurs after docking.
2 Q4KUS2 (/ISO) Q9Z1N9 (/ISO)
Positive regulation of inhibitory postsynaptic potential GO:0097151
Any process that activates or increases the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential.
2 O14795 (/ISS) Q9Z1N9 (/ISS)
Positive regulation of neurotransmitter secretion GO:0001956
Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter.
1 Q4KUS2 (/IMP)
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
1 Q62768 (/IDA)
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
1 Q4KUS2 (/ISO)
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
1 O14795 (/TAS)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 P27715 (/IGI)
Regulation of synaptic vesicle priming GO:0010807
Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion.
1 Q62768 (/IDA)
Regulation of synaptic vesicle priming GO:0010807
Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion.
1 Q4KUS2 (/ISO)
Regulation of synaptic vesicle priming GO:0010807
Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion.
1 Q4KUS2 (/TAS)
Positive regulation of synaptic vesicle priming GO:0010808
Any process that increases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion.
1 Q9Z1N9 (/ISO)
Glutamate secretion GO:0014047
The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system.
1 O14795 (/TAS)
Synaptic vesicle priming GO:0016082
A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.
1 Q62768 (/IDA)
Synaptic vesicle maturation GO:0016188
Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle.
1 Q4KUS2 (/IMP)
Positive regulation of synaptic plasticity GO:0031915
A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
1 Q4KUS2 (/IGI)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 O14795 (/IDA)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q9Z1N9 (/ISO)
Positive regulation of exocytosis GO:0045921
Any process that activates or increases the frequency, rate or extent of exocytosis.
1 Q62769 (/IMP)
Positive regulation of exocytosis GO:0045921
Any process that activates or increases the frequency, rate or extent of exocytosis.
1 Q9Z1N9 (/ISO)
Regulation of neurotransmitter secretion GO:0046928
Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.
1 Q62770 (/TAS)
Amyloid-beta metabolic process GO:0050435
The chemical reactions and pathways involving amyloid-beta, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP).
1 Q4KUS2 (/IMP)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
1 O14795 (/IDA)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
1 Q62769 (/IMP)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
1 Q9Z1N9 (/ISO)
Regulation of synaptic transmission, glutamatergic GO:0051966
Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
1 Q9UPW8 (/TAS)
Positive regulation of oocyte development GO:0060282
Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
1 P27715 (/IGI)
Long-term synaptic potentiation GO:0060291
A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse.
1 Q62768 (/IMP)
Long-term synaptic potentiation GO:0060291
A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse.
1 Q4KUS2 (/ISO)
Acrosomal vesicle exocytosis GO:0060478
The calcium ion regulated exocytosis which results in fusion of the acrosomal vesicle with the plasma membrane of the sperm as part of the acrosome reaction.
1 O14795 (/IDA)
Acrosomal vesicle exocytosis GO:0060478
The calcium ion regulated exocytosis which results in fusion of the acrosomal vesicle with the plasma membrane of the sperm as part of the acrosome reaction.
1 Q9Z1N9 (/ISO)
Spontaneous neurotransmitter secretion GO:0061669
Neurotransmitter secretion that occurs in the absence of the action of a secretagogue or a presynaptic action potential.
1 Q9Z1N9 (/ISO)
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 O14795 (/IDA)
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 Q62769 (/IMP)
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 Q9Z1N9 (/ISO)
Phagosome maturation GO:0090382
A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.
1 Q9Z1N9 (/IMP)
Positive regulation of inhibitory postsynaptic potential GO:0097151
Any process that activates or increases the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential.
1 Q9Z1N9 (/ISO)
Synaptic vesicle tethering involved in synaptic vesicle exocytosis GO:0099069
The initial, indirect interaction between a synaptic vesicle membrane and a the preseynaptic membrane active zone. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. This process is distinct from and prior to synaptic vesicle priming and fusion.
1 H9XVP2 (/IMP)
Presynaptic dense core vesicle exocytosis GO:0099525
The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels.
1 Q4KUS2 (/IGI)
Presynaptic dense core vesicle exocytosis GO:0099525
The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels.
1 Q9Z1N9 (/IMP)
Positive regulation of defense response to bacterium GO:1900426
Any process that activates or increases the frequency, rate or extent of defense response to bacterium.
1 Q9Z1N9 (/IMP)
Positive regulation of glutamate receptor signaling pathway GO:1900451
Any process that activates or increases the frequency, rate or extent of glutamate receptor signaling pathway.
1 Q4KUS2 (/IMP)
Regulation of amyloid precursor protein catabolic process GO:1902991
Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process.
1 Q4KUS2 (/IMP)
Positive regulation of dendrite extension GO:1903861
Any process that activates or increases the frequency, rate or extent of dendrite extension.
1 Q9UPW8 (/IDA)
Positive regulation of dendrite extension GO:1903861
Any process that activates or increases the frequency, rate or extent of dendrite extension.
1 Q4KUS2 (/ISO)

There are 52 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
9 H9XVP2 (/ISS) O96959 (/ISS) O96960 (/ISS) Q8IM86 (/ISS) Q8IM87 (/ISS) Q8T049 (/ISS) Q9U4K9 (/ISS) Q9V483 (/ISS) X2J9E1 (/ISS)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
9 H9XVP2 (/NAS) O96959 (/NAS) O96960 (/NAS) Q8IM86 (/NAS) Q8IM87 (/NAS) Q8T049 (/NAS) Q9U4K9 (/NAS) Q9V483 (/NAS) X2J9E1 (/NAS)
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
9 H9XVP2 (/IDA) O96959 (/IDA) O96960 (/IDA) Q8IM86 (/IDA) Q8IM87 (/IDA) Q8T049 (/IDA) Q9U4K9 (/IDA) Q9V483 (/IDA) X2J9E1 (/IDA)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
9 H9XVP2 (/IDA) O96959 (/IDA) O96960 (/IDA) Q8IM86 (/IDA) Q8IM87 (/IDA) Q8T049 (/IDA) Q9U4K9 (/IDA) Q9V483 (/IDA) X2J9E1 (/IDA)
Presynaptic active zone GO:0048786
A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.
6 G5EDN9 (/IDA) H9XVP2 (/IDA) P27715 (/IDA) Q4KUS2 (/IDA) Q62768 (/IDA) Q9Z1N9 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 H9XVP2 (/ISS) O14795 (/ISS) Q8K0T7 (/ISS) Q8NB66 (/ISS) Q9Z1N9 (/ISS)
Presynaptic membrane GO:0042734
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
3 H9XVP2 (/ISS) Q4KUS2 (/ISS) Q9UPW8 (/ISS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
3 H9XVP2 (/ISS) Q4KUS2 (/ISS) Q9UPW8 (/ISS)
Calyx of Held GO:0044305
The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system.
3 Q4KUS2 (/IDA) Q8K0T7 (/IDA) Q9Z1N9 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
3 G5EDN9 (/IDA) P27715 (/IDA) Q4KUS2 (/IDA)
Presynaptic active zone GO:0048786
A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.
3 O14795 (/TAS) Q8NB66 (/TAS) Q9UPW8 (/TAS)
Presynapse GO:0098793
The part of a synapse that is part of the presynaptic cell.
3 Q4KUS2 (/IDA) Q8K0T7 (/IDA) Q9Z1N9 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O14795 (/IDA) Q62769 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q8K0T7 (/ISO) Q9Z1N9 (/ISO)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
2 Q4KUS2 (/IDA) Q9Z1N9 (/IDA)
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
2 O14795 (/ISS) Q9Z1N9 (/ISS)
Calyx of Held GO:0044305
The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system.
2 Q8K0T7 (/ISS) Q9Z1N9 (/ISS)
Presynaptic active zone GO:0048786
A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.
2 Q4KUS2 (/IC) Q9Z1N9 (/IC)
Synaptic membrane GO:0097060
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
2 Q62768 (/IDA) Q62769 (/IDA)
Synaptic membrane GO:0097060
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
2 Q4KUS2 (/ISO) Q9Z1N9 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
2 Q4KUS2 (/IDA) Q9Z1N9 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
2 Q4KUS2 (/IMP) Q9Z1N9 (/IMP)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 O14795 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q9Z1N9 (/ISO)
Golgi-associated vesicle GO:0005798
Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.
1 Q62768 (/IDA)
Golgi-associated vesicle GO:0005798
Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.
1 Q4KUS2 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9Z1N9 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O14795 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q62770 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 O14795 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9Z1N9 (/ISO)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 Q4KUS2 (/IDA)
Synaptic vesicle membrane GO:0030672
The lipid bilayer surrounding a synaptic vesicle.
1 Q62770 (/IDA)
Synaptic vesicle membrane GO:0030672
The lipid bilayer surrounding a synaptic vesicle.
1 Q8K0T7 (/ISO)
Early phagosome GO:0032009
A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.
1 Q9Z1N9 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q62768 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q4KUS2 (/ISO)
Presynaptic membrane GO:0042734
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
1 Q62768 (/IDA)
Presynaptic membrane GO:0042734
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
1 Q4KUS2 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q62768 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q4KUS2 (/ISO)
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
1 Q62768 (/HDA)
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
1 Q9Z1N9 (/ISO)
Presynaptic active zone GO:0048786
A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.
1 Q4KUS2 (/ISO)
Excitatory synapse GO:0060076
A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.
1 Q62768 (/IDA)
Excitatory synapse GO:0060076
A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.
1 Q4KUS2 (/ISO)
Ribbon synapse GO:0097470
Type of synapse characterized by an electron-dense ribbon, lamella (bar) or spherical body in the presynaptic process cytoplasm.
1 Q9Z1N9 (/IDA)
Hippocampal mossy fiber to CA3 synapse GO:0098686
One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell.
1 Q9Z1N9 (/IDA)
Hippocampal mossy fiber to CA3 synapse GO:0098686
One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell.
1 Q9Z1N9 (/IMP)
Parallel fiber to Purkinje cell synapse GO:0098688
An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells.
1 Q8K0T7 (/IMP)
Presynaptic active zone cytoplasmic component GO:0098831
A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles.
1 Q62768 (/IDA)
Presynaptic active zone cytoplasmic component GO:0098831
A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles.
1 Q4KUS2 (/ISO)