The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 774: Hepatitis A virus cellular receptor 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q5QNS5 (/IPI) Q6U7R4 (/IPI) Q8TDQ0 (/IPI) Q8VIM0 (/IPI)
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
2 Q5QNS5 (/IDA) Q6U7R4 (/IDA)
Virus receptor activity GO:0001618
Combining with a virus component and mediating entry of the virus into the cell.
1 Q96D42 (/IDA)
Virus receptor activity GO:0001618
Combining with a virus component and mediating entry of the virus into the cell.
1 O46598 (/IMP)
Ferritin receptor activity GO:0070287
Combining with ferritin, and delivering ferritin into the cell via endocytosis.
1 Q8R183 (/IDA)

There are 70 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Apoptotic cell clearance GO:0043277
The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
7 A0A1C6ZYS3 (/IMP) A0A1C6ZYS5 (/IMP) A0A2R8QGQ2 (/IMP) E9QEV2 (/IMP) E9QGJ4 (/IMP) F1QLX9 (/IMP) Q6DH50 (/IMP)
Engulfment of apoptotic cell GO:0043652
The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte.
7 A0A1C6ZYS3 (/IMP) A0A1C6ZYS5 (/IMP) A0A2R8QGQ2 (/IMP) E9QEV2 (/IMP) E9QGJ4 (/IMP) F1QLX9 (/IMP) Q6DH50 (/IMP)
Cytoskeletal rearrangement involved in phagocytosis, engulfment GO:0060097
The assembly, arrangement, or disassembly of cytoskeletal structures that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
7 A0A1C6ZYS3 (/IMP) A0A1C6ZYS5 (/IMP) A0A2R8QGQ2 (/IMP) E9QEV2 (/IMP) E9QGJ4 (/IMP) F1QLX9 (/IMP) Q6DH50 (/IMP)
Maternal process involved in female pregnancy GO:0060135
A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.
2 Q8TDQ0 (/IDA) Q8VIM0 (/IDA)
Positive regulation of tumor necrosis factor secretion GO:1904469
Any process that activates or increases the frequency, rate or extent of tumor necrosis factor secretion.
2 Q8TDQ0 (/IMP) Q8VIM0 (/IMP)
Positive regulation of cytokine production GO:0001819
Any process that activates or increases the frequency, rate or extent of production of a cytokine.
1 Q8VIM0 (/IMP)
Macrophage activation involved in immune response GO:0002281
A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
1 Q8VIM0 (/IMP)
Natural killer cell tolerance induction GO:0002519
Tolerance induction of natural killer cells.
1 Q8TDQ0 (/IMP)
Natural killer cell tolerance induction GO:0002519
Tolerance induction of natural killer cells.
1 Q8VIM0 (/ISO)
Regulation of tolerance induction dependent upon immune response GO:0002652
Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response.
1 Q8VIM0 (/IMP)
Negative regulation of T-helper 1 type immune response GO:0002826
Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response.
1 Q8VIM0 (/IMP)
Negative regulation of immune response to tumor cell GO:0002838
Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell.
1 Q8VIM0 (/IMP)
Negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002859
Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.
1 Q8VIM0 (/IMP)
Iron ion transport GO:0006826
The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q8R183 (/IDA)
Phagocytosis, engulfment GO:0006911
The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
1 O54947 (/IMP)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
1 O54947 (/IEP)
Response to mycotoxin GO:0010046
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi.
1 O54947 (/IEP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q8TDQ0 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q8VIM0 (/ISO)
Negative regulation of myeloid dendritic cell activation GO:0030886
Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation.
1 Q8TDQ0 (/IMP)
Negative regulation of myeloid dendritic cell activation GO:0030886
Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation.
1 Q8VIM0 (/ISO)
Fin regeneration GO:0031101
The regrowth of fin tissue following its loss or destruction.
1 Q1LXE2 (/IGI)
Fin regeneration GO:0031101
The regrowth of fin tissue following its loss or destruction.
1 Q1LXE2 (/IMP)
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
1 Q8TDQ0 (/IMP)
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
1 Q8VIM0 (/ISO)
Negative regulation of type I interferon production GO:0032480
Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
1 Q8VIM0 (/IMP)
Negative regulation of interferon-alpha production GO:0032687
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production.
1 Q8TDQ0 (/IDA)
Negative regulation of interferon-alpha production GO:0032687
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production.
1 Q8VIM0 (/ISO)
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
1 Q8TDQ0 (/IDA)
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
1 Q8VIM0 (/IMP)
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
1 Q8VIM0 (/ISO)
Negative regulation of interleukin-2 production GO:0032703
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
1 Q8TDQ0 (/IDA)
Negative regulation of interleukin-2 production GO:0032703
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
1 Q8VIM0 (/IMP)
Negative regulation of interleukin-2 production GO:0032703
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
1 Q8VIM0 (/ISO)
Negative regulation of interleukin-3 production GO:0032712
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-3 production.
1 Q8TDQ0 (/IDA)
Negative regulation of interleukin-3 production GO:0032712
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-3 production.
1 Q8VIM0 (/ISO)
Negative regulation of interleukin-6 production GO:0032715
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.
1 Q8VIM0 (/IMP)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
1 Q8TDQ0 (/IMP)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
1 Q8VIM0 (/ISO)
Positive regulation of chemokine production GO:0032722
Any process that activates or increases the frequency, rate, or extent of chemokine production.
1 Q8VIM0 (/IMP)
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
1 Q8VIM0 (/IMP)
Positive regulation of interleukin-1 production GO:0032732
Any process that activates or increases the frequency, rate, or extent of interleukin-1 production.
1 Q8VIM0 (/IMP)
Positive regulation of interleukin-4 production GO:0032753
Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
1 Q8TDQ0 (/IMP)
Positive regulation of interleukin-4 production GO:0032753
Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
1 Q8VIM0 (/ISO)
Negative regulation of natural killer cell activation GO:0032815
Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation.
1 Q8VIM0 (/IMP)
Positive regulation of mast cell activation GO:0033005
Any process that activates or increases the frequency, rate, or extent of mast cell activation.
1 Q5QNS5 (/IDA)
Response to testosterone GO:0033574
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
1 O54947 (/IEP)
Toll-like receptor 3 signaling pathway GO:0034138
Any series of molecular signals generated as a consequence of binding to toll-like receptor 3.
1 Q8VIM0 (/IMP)
Toll-like receptor 7 signaling pathway GO:0034154
Any series of molecular signals generated as a consequence of binding to toll-like receptor 7.
1 Q8VIM0 (/IMP)
Toll-like receptor 9 signaling pathway GO:0034162
Any series of molecular signals generated as a consequence of binding to toll-like receptor 9.
1 Q8VIM0 (/IMP)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
1 Q8VIM0 (/IMP)
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
1 Q8VIM0 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 O54947 (/IEP)
Positive regulation of macrophage activation GO:0043032
Any process that stimulates, induces or increases the rate of macrophage activation.
1 Q8VIM0 (/IMP)
Positive regulation of innate immune response GO:0045089
Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
1 Q8VIM0 (/IMP)
Negative regulation of innate immune response GO:0045824
Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.
1 Q8VIM0 (/IMP)
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
1 O54947 (/IEP)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
1 Q8VIM0 (/IMP)
Maternal process involved in female pregnancy GO:0060135
A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.
1 Q8VIM0 (/ISO)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q8VIM0 (/IDA)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q8VIM0 (/IDA)
Negative regulation of granulocyte colony-stimulating factor production GO:0071656
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granulocyte colony stimulating factor.
1 Q8TDQ0 (/IDA)
Negative regulation of granulocyte colony-stimulating factor production GO:0071656
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granulocyte colony stimulating factor.
1 Q8VIM0 (/ISO)
Negative regulation of defense response to bacterium GO:1900425
Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium.
1 Q8VIM0 (/IMP)
Positive regulation of defense response to bacterium GO:1900426
Any process that activates or increases the frequency, rate or extent of defense response to bacterium.
1 Q8VIM0 (/IMP)
Positive regulation of NIK/NF-kappaB signaling GO:1901224
Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
1 Q8VIM0 (/IDA)
Positive regulation of tumor necrosis factor secretion GO:1904469
Any process that activates or increases the frequency, rate or extent of tumor necrosis factor secretion.
1 Q8VIM0 (/ISO)
Negative regulation of immunological synapse formation GO:2000521
Any process that stops, prevents or reduces the frequency, rate or extent of immunological synapse formation.
1 Q8VIM0 (/IMP)
Negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:2001189
Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell.
1 Q8TDQ0 (/IDA)
Negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:2001189
Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell.
1 Q8VIM0 (/ISO)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
6 O54947 (/IDA) P0C0K5 (/IDA) Q5QNS5 (/IDA) Q8R183 (/IDA) Q8TDQ0 (/IDA) Q8VIM0 (/IDA)
Motile cilium GO:0031514
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
2 O46598 (/IDA) Q96D42 (/IDA)
Immunological synapse GO:0001772
An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
1 Q8VIM0 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 O54947 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O54947 (/IDA)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
1 Q8VIM0 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8VIM0 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q8VIM0 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q8VIM0 (/ISS)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 O54947 (/IDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 O54947 (/IDA)