The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 287: Prolactin receptor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Prolactin receptor activity GO:0004925
Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
3 P16471 (/NAS) P16471 (/NAS) Q865V4 (/NAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P16471 (/IPI) P16471 (/IPI) Q08501 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 P16471 (/NAS) P16471 (/NAS) Q865V4 (/NAS)
Prolactin receptor activity GO:0004925
Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2 P05710 (/IMP) Q08501 (/IMP)
Prolactin receptor activity GO:0004925
Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2 P16471 (/TAS) P16471 (/TAS)
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
2 P16471 (/IPI) P16471 (/IPI)
Ornithine decarboxylase activator activity GO:0042978
Upregulation of the activity of the enzyme ornithine decarboxylase.
2 P16471 (/NAS) P16471 (/NAS)
Prolactin receptor activity GO:0004925
Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
1 Q08501 (/IDA)
Prolactin receptor activity GO:0004925
Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
1 Q08501 (/ISO)
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
1 Q9DE08 (/IDA)
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
1 Q9DE08 (/IMP)
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
1 Q08501 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 P05710 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q08501 (/ISO)

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
6 A0A0G2K488 (/ISS) A0A0G2K813 (/ISS) P05710 (/ISS) P16471 (/ISS) P16471 (/ISS) Q58DZ7 (/ISS)
Steroid biosynthetic process GO:0006694
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
3 P16471 (/NAS) P16471 (/NAS) Q865V4 (/NAS)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
3 P16471 (/NAS) P16471 (/NAS) Q865V4 (/NAS)
Activation of transmembrane receptor protein tyrosine kinase activity GO:0007171
Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity.
3 P16471 (/IDA) P16471 (/IDA) Q865V4 (/IDA)
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
3 P16471 (/NAS) P16471 (/NAS) Q865V4 (/NAS)
T cell activation GO:0042110
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
3 P16471 (/NAS) P16471 (/NAS) Q865V4 (/NAS)
Activation of Janus kinase activity GO:0042976
The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.
3 P16471 (/NAS) P16471 (/NAS) Q865V4 (/NAS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
3 P16471 (/NAS) P16471 (/NAS) Q865V4 (/NAS)
Embryo implantation GO:0007566
Attachment of the blastocyst to the uterine lining.
2 P16471 (/TAS) P16471 (/TAS)
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
2 P16471 (/TAS) P16471 (/TAS)
Growth hormone receptor signaling pathway via JAK-STAT GO:0060397
The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
2 P16471 (/TAS) P16471 (/TAS)
Activation of transmembrane receptor protein tyrosine kinase activity GO:0007171
Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity.
1 Q08501 (/ISO)
Receptor signaling pathway via JAK-STAT GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
1 Q08501 (/IMP)
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
1 Q08501 (/IGI)
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
1 Q08501 (/IMP)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
1 Q08501 (/IEP)
Regulation of cell adhesion GO:0030155
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
1 Q08501 (/IMP)
Regulation of epithelial cell differentiation GO:0030856
Any process that modulates the frequency, rate or extent of epithelial cell differentiation.
1 Q08501 (/IMP)
Protein complex oligomerization GO:0051259
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 Q9DE08 (/IDA)
Mammary gland epithelial cell differentiation GO:0060644
The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland.
1 Q08501 (/IGI)
Prostate gland growth GO:0060736
The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state.
1 Q08501 (/IMP)
Mammary gland alveolus development GO:0060749
The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland.
1 Q08501 (/IGI)
Mammary gland alveolus development GO:0060749
The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland.
1 Q08501 (/IMP)
Mammary gland epithelium development GO:0061180
The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
1 Q08501 (/IMP)
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
1 Q08501 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
7 P05710 (/TAS) P16471 (/TAS) P16471 (/TAS) Q04594 (/TAS) Q04594 (/TAS) Q90374 (/TAS) Q90374 (/TAS)
Spanning component of plasma membrane GO:0044214
The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane.
4 G1MVP3 (/ISS) G1MVP3 (/ISS) Q91094 (/ISS) Q91094 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 F1N4H8 (/IDA) Q28172 (/IDA) Q2PBN9 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
3 P16471 (/IDA) P16471 (/IDA) Q865V4 (/IDA)
Endosome lumen GO:0031904
The volume enclosed by the membrane of an endosome.
2 P16471 (/TAS) P16471 (/TAS)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
1 Q9DE08 (/ISS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q08501 (/ISO)