The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13: CD40 ligand

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
CD40 receptor binding GO:0005174
Interacting selectively and non-covalently with CD40, a receptor found on the surface of all B-lymphocytes.
27 O97605 (/ISS) O97626 (/ISS) O97626 (/ISS) P27548 (/ISS) P27548 (/ISS) P51749 (/ISS) P51749 (/ISS) P63304 (/ISS) P63304 (/ISS) P63304 (/ISS)
(17 more)
CD40 receptor binding GO:0005174
Interacting selectively and non-covalently with CD40, a receptor found on the surface of all B-lymphocytes.
2 P29965 (/IPI) Q9Z2V2 (/IPI)
CD40 receptor binding GO:0005174
Interacting selectively and non-covalently with CD40, a receptor found on the surface of all B-lymphocytes.
2 P27548 (/ISO) P27548 (/ISO)
CD40 receptor binding GO:0005174
Interacting selectively and non-covalently with CD40, a receptor found on the surface of all B-lymphocytes.
1 B8YI05 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P29965 (/IPI)

There are 63 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
27 O97605 (/ISS) O97626 (/ISS) O97626 (/ISS) P27548 (/ISS) P27548 (/ISS) P51749 (/ISS) P51749 (/ISS) P63304 (/ISS) P63304 (/ISS) P63304 (/ISS)
(17 more)
Activation of JUN kinase activity GO:0007257
The initiation of the activity of the inactive enzyme JUN kinase (JNK).
27 O97605 (/ISS) O97626 (/ISS) O97626 (/ISS) P27548 (/ISS) P27548 (/ISS) P51749 (/ISS) P51749 (/ISS) P63304 (/ISS) P63304 (/ISS) P63304 (/ISS)
(17 more)
Platelet activation GO:0030168
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
27 O97605 (/ISS) O97626 (/ISS) O97626 (/ISS) P27548 (/ISS) P27548 (/ISS) P51749 (/ISS) P51749 (/ISS) P63304 (/ISS) P63304 (/ISS) P63304 (/ISS)
(17 more)
Positive regulation of interleukin-4 production GO:0032753
Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
27 O97605 (/ISS) O97626 (/ISS) O97626 (/ISS) P27548 (/ISS) P27548 (/ISS) P51749 (/ISS) P51749 (/ISS) P63304 (/ISS) P63304 (/ISS) P63304 (/ISS)
(17 more)
B cell proliferation GO:0042100
The expansion of a B cell population by cell division. Follows B cell activation.
27 O97605 (/ISS) O97626 (/ISS) O97626 (/ISS) P27548 (/ISS) P27548 (/ISS) P51749 (/ISS) P51749 (/ISS) P63304 (/ISS) P63304 (/ISS) P63304 (/ISS)
(17 more)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
27 O97605 (/ISS) O97626 (/ISS) O97626 (/ISS) P27548 (/ISS) P27548 (/ISS) P51749 (/ISS) P51749 (/ISS) P63304 (/ISS) P63304 (/ISS) P63304 (/ISS)
(17 more)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
27 O97605 (/ISS) O97626 (/ISS) O97626 (/ISS) P27548 (/ISS) P27548 (/ISS) P51749 (/ISS) P51749 (/ISS) P63304 (/ISS) P63304 (/ISS) P63304 (/ISS)
(17 more)
Positive regulation of interleukin-10 production GO:0032733
Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
26 O97605 (/ISS) O97626 (/ISS) O97626 (/ISS) P27548 (/ISS) P27548 (/ISS) P51749 (/ISS) P51749 (/ISS) P63304 (/ISS) P63304 (/ISS) P63304 (/ISS)
(16 more)
Positive regulation of immune response to tumor cell GO:0002839
Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell.
2 P27548 (/ISO) P27548 (/ISO)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
2 P27548 (/ISO) P27548 (/ISO)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2 P27548 (/NAS) P27548 (/NAS)
Activation of JUN kinase activity GO:0007257
The initiation of the activity of the inactive enzyme JUN kinase (JNK).
2 P27548 (/ISO) P27548 (/ISO)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P27548 (/ISO) P27548 (/ISO)
Platelet activation GO:0030168
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
2 P27548 (/ISO) P27548 (/ISO)
B cell differentiation GO:0030183
The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
2 P27548 (/IGI) P27548 (/IGI)
Positive regulation of B cell proliferation GO:0030890
Any process that activates or increases the rate or extent of B cell proliferation.
2 P27548 (/ISO) P27548 (/ISO)
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
2 P27548 (/ISO) P27548 (/ISO)
Positive regulation of interleukin-10 production GO:0032733
Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
2 P29965 (/IDA) Q9Z2V2 (/IDA)
Positive regulation of interleukin-10 production GO:0032733
Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
2 P27548 (/ISO) P27548 (/ISO)
Positive regulation of interleukin-12 production GO:0032735
Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.
2 P29965 (/IDA) Q9Z2V2 (/IDA)
Positive regulation of interleukin-12 production GO:0032735
Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.
2 P27548 (/ISO) P27548 (/ISO)
Positive regulation of interleukin-4 production GO:0032753
Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
2 P27548 (/ISO) P27548 (/ISO)
B cell proliferation GO:0042100
The expansion of a B cell population by cell division. Follows B cell activation.
2 P27548 (/ISO) P27548 (/ISO)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
2 P27548 (/ISO) P27548 (/ISO)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 P27548 (/ISO) P27548 (/ISO)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 P27548 (/ISS) P27548 (/ISS)
Isotype switching GO:0045190
The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.
2 P27548 (/IDA) P27548 (/IDA)
Positive regulation of MHC class II biosynthetic process GO:0045348
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.
2 P27548 (/ISO) P27548 (/ISO)
Immunoglobulin secretion GO:0048305
The regulated release of immunoglobulins from a B cell or plasma cell, whose mechanism includes the use of alternate polyadenylylation signals to favor the biosynthesis of secreted forms of immunoglobulin over membrane-bound immunoglobulin.
2 P27548 (/IGI) P27548 (/IGI)
Regulation of immunoglobulin secretion GO:0051023
Any process that modulates the frequency, rate or extent of the regulated release of immunoglobulins from a cell.
2 P27548 (/IDA) P27548 (/IDA)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
2 P27548 (/ISO) P27548 (/ISO)
Dendritic cell differentiation GO:0097028
The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.
2 P27548 (/ISO) P27548 (/ISO)
Positive regulation of endothelial cell apoptotic process GO:2000353
Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process.
2 P27548 (/ISO) P27548 (/ISO)
Positive regulation of dendritic cell differentiation GO:2001200
Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation.
2 P27548 (/ISO) P27548 (/ISO)
Positive regulation of immunoglobulin production GO:0002639
Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.
1 B8YI05 (/IDA)
Positive regulation of immune response to tumor cell GO:0002839
Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell.
1 Q9Z2V2 (/IDA)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 P29965 (/IDA)
Leukocyte cell-cell adhesion GO:0007159
The attachment of a leukocyte to another cell via adhesion molecules.
1 P29965 (/NAS)
Activation of JUN kinase activity GO:0007257
The initiation of the activity of the inactive enzyme JUN kinase (JNK).
1 P29965 (/IDA)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9Z2V2 (/IDA)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 B9ENV6 (/IMP)
Platelet activation GO:0030168
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
1 P29965 (/IDA)
Positive regulation of B cell proliferation GO:0030890
Any process that activates or increases the rate or extent of B cell proliferation.
1 Q9Z2V2 (/IDA)
T cell costimulation GO:0031295
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.
1 P29965 (/TAS)
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
1 Q9Z2V2 (/IDA)
Positive regulation of interleukin-4 production GO:0032753
Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
1 P29965 (/IDA)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P29965 (/TAS)
Response to cobalamin GO:0033590
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus.
1 Q9Z2V2 (/IEP)
B cell proliferation GO:0042100
The expansion of a B cell population by cell division. Follows B cell activation.
1 P29965 (/IDA)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
1 P29965 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P29965 (/IDA)
Isotype switching GO:0045190
The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.
1 P29965 (/ISS)
Leukocyte activation GO:0045321
A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.
1 B9ENV6 (/IMP)
Positive regulation of MHC class II biosynthetic process GO:0045348
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.
1 Q9Z2V2 (/IDA)
Negative regulation of endocytosis GO:0045806
Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.
1 B9ENV6 (/IMP)
Cell maturation GO:0048469
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
1 B9ENV6 (/IMP)
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
1 P29965 (/TAS)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
1 P29965 (/IDA)
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 Q9Z2V2 (/IEP)
Dendritic cell differentiation GO:0097028
The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.
1 Q9Z2V2 (/IMP)
Response to peptide GO:1901652
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.
1 Q9Z2V2 (/IEP)
Positive regulation of endothelial cell apoptotic process GO:2000353
Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process.
1 P29965 (/IDA)
Positive regulation of dendritic cell differentiation GO:2001200
Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation.
1 Q9Z2V2 (/IDA)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
24 O97605 (/ISS) O97626 (/ISS) O97626 (/ISS) P51749 (/ISS) P51749 (/ISS) P63304 (/ISS) P63304 (/ISS) P63304 (/ISS) P63304 (/ISS) P63304 (/ISS)
(14 more)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
3 B8YI05 (/IDA) P27548 (/IDA) P27548 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P27548 (/ISO) P27548 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 P29965 (/IDA) Q9Z2V2 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 P27548 (/ISO) P27548 (/ISO)
Cell projection GO:0042995
A prolongation or process extending from a cell, e.g. a flagellum or axon.
2 P27548 (/ISO) P27548 (/ISO)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
2 P27548 (/ISO) P27548 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q9Z2V2 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P29965 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P29965 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P29965 (/NAS)
Cell projection GO:0042995
A prolongation or process extending from a cell, e.g. a flagellum or axon.
1 Q9Z2V2 (/IDA)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
1 Q9Z2V2 (/IDA)