The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 606: Growth arrest-specific protein 6

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
1 G3I7Z5 (/ISS)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 G3I7Z5 (/ISS)
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
1 G3I7Z5 (/ISS)
Protein tyrosine kinase activator activity GO:0030296
Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein.
1 G3I7Z5 (/ISS)
Protein binding, bridging GO:0030674
The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
1 G3I7Z5 (/ISS)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027
Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
1 G3I7Z5 (/ISS)

There are 46 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 G3I7Z5 (/ISS)
Positive regulation of cytokine-mediated signaling pathway GO:0001961
Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway.
1 G3I7Z5 (/ISS)
Positive regulation of glomerular filtration GO:0003104
Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule.
1 G3I7Z5 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 G3I7Z5 (/ISS)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 G3I7Z5 (/ISS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 G3I7Z5 (/ISS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 G3I7Z5 (/ISS)
Negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804
Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
1 G3I7Z5 (/ISS)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
1 G3I7Z5 (/ISS)
Fusion of virus membrane with host plasma membrane GO:0019064
Fusion of a viral membrane with the host cell membrane during viral entry. Results in release of the virion contents into the cytoplasm.
1 G3I7Z5 (/ISS)
Viral genome replication GO:0019079
Any process involved directly in viral genome replication, including viral nucleotide metabolism.
1 G3I7Z5 (/ISS)
Positive regulation of TOR signaling GO:0032008
Any process that activates or increases the frequency, rate or extent of TOR signaling.
1 G3I7Z5 (/ISS)
Activation of protein kinase B activity GO:0032148
Any process that initiates the activity of the inactive enzyme protein kinase B.
1 G3I7Z5 (/ISS)
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
1 G3I7Z5 (/ISS)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
1 G3I7Z5 (/ISS)
Positive regulation of natural killer cell differentiation GO:0032825
Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation.
1 G3I7Z5 (/ISS)
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
1 G3I7Z5 (/ISS)
Cellular response to interferon-alpha GO:0035457
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.
1 G3I7Z5 (/ISS)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 G3I7Z5 (/ISS)
B cell chemotaxis GO:0035754
The directed movement of a B cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 G3I7Z5 (/ISS)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
1 G3I7Z5 (/ISS)
Apoptotic cell clearance GO:0043277
The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
1 G3I7Z5 (/ISS)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 G3I7Z5 (/ISS)
Protein kinase B signaling GO:0043491
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.
1 G3I7Z5 (/ISS)
Positive regulation of protein kinase activity GO:0045860
Any process that activates or increases the frequency, rate or extent of protein kinase activity.
1 G3I7Z5 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 G3I7Z5 (/ISS)
Viral entry into host cell GO:0046718
The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
1 G3I7Z5 (/ISS)
Receptor-mediated virion attachment to host cell GO:0046813
The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface.
1 G3I7Z5 (/ISS)
Positive regulation of protein export from nucleus GO:0046827
Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.
1 G3I7Z5 (/ISS)
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
1 G3I7Z5 (/ISS)
Negative regulation of interleukin-1 secretion GO:0050711
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 from a cell.
1 G3I7Z5 (/ISS)
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
1 G3I7Z5 (/ISS)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
1 G3I7Z5 (/ISS)
Positive regulation of protein tyrosine kinase activity GO:0061098
Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.
1 G3I7Z5 (/ISS)
Negative regulation of biomineral tissue development GO:0070168
Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.
1 G3I7Z5 (/ISS)
Cellular response to vitamin K GO:0071307
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus.
1 G3I7Z5 (/ISS)
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 G3I7Z5 (/ISS)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
1 G3I7Z5 (/ISS)
Extracellular matrix assembly GO:0085029
The aggregation, arrangement and bonding together of the extracellular matrix.
1 G3I7Z5 (/ISS)
Hematopoietic stem cell migration to bone marrow GO:0097241
The orderly movement of a hematopoietic stem cell into the bone marrow, and its subsequent positioning within defined functional compartments in that microenvironment. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.
1 G3I7Z5 (/ISS)
Negative regulation of oligodendrocyte apoptotic process GO:1900142
Any process that stops, prevents or reduces the frequency, rate or extent of oligodendrocyte apoptotic process.
1 G3I7Z5 (/ISS)
Negative regulation of interleukin-6 secretion GO:1900165
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-6 secretion.
1 G3I7Z5 (/ISS)
Negative regulation of fibroblast apoptotic process GO:2000270
Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process.
1 G3I7Z5 (/ISS)
Negative regulation of endothelial cell apoptotic process GO:2000352
Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process.
1 G3I7Z5 (/ISS)
Negative regulation of renal albumin absorption GO:2000533
Any process that stops, prevents or reduces the frequency, rate or extent of renal albumin absorption.
1 G3I7Z5 (/ISS)
Negative regulation of dendritic cell apoptotic process GO:2000669
Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process.
1 G3I7Z5 (/ISS)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 G3I7Z5 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 G3I7Z5 (/ISS)