The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Translation factors
".
FunFam 17: Eukaryotic peptide chain release factor GTP-bindin...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 19 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
13 |
O74718 (/IPI)
P05453 (/IPI)
P05453 (/IPI)
P15170 (/IPI)
P15170 (/IPI)
P15170 (/IPI)
P15170 (/IPI)
Q7LKB1 (/IPI)
Q7LKB1 (/IPI)
Q7LKB1 (/IPI)
(3 more) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
5 | P15170 (/HDA) P15170 (/HDA) P15170 (/HDA) P15170 (/HDA) Q8IYD1 (/HDA) |
|
Translation release factor activity GO:0003747
Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.
|
4 | P15170 (/IMP) P15170 (/IMP) P15170 (/IMP) P15170 (/IMP) |
|
Translation release factor activity GO:0003747
Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.
|
4 | A7YWL9 (/ISS) Q59YE8 (/ISS) Q8R050 (/ISS) Q9N2G7 (/ISS) |
|
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
|
4 | P15170 (/TAS) P15170 (/TAS) P15170 (/TAS) P15170 (/TAS) |
|
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
|
3 | M9PD08 (/NAS) P91944 (/NAS) Q9VK85 (/NAS) |
|
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
3 | M9PD08 (/ISS) P91944 (/ISS) Q9VK85 (/ISS) |
|
Translation termination factor activity GO:0008079
Functions in the termination of translation.
|
3 | M9PD08 (/ISS) P91944 (/ISS) Q9VK85 (/ISS) |
|
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
|
2 | P05453 (/HDA) P05453 (/HDA) |
|
Translation release factor activity GO:0003747
Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.
|
2 | P05453 (/IDA) P05453 (/IDA) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
2 | P05453 (/IPI) P05453 (/IPI) |
|
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
1 | O74718 (/IMP) |
|
Translation release factor activity GO:0003747
Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.
|
1 | Q59YE8 (/IGI) |
|
Translation release factor activity GO:0003747
Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.
|
1 | Q8R050 (/ISO) |
|
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | O74718 (/IMP) |
|
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
1 | O74718 (/IDA) |
|
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
1 | O74718 (/IMP) |
|
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | O74718 (/IPI) |
|
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
|
1 | O74718 (/IMP) |
There are 12 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184
The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
|
5 | P15170 (/TAS) P15170 (/TAS) P15170 (/TAS) P15170 (/TAS) Q8IYD1 (/TAS) |
|
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
|
4 | P15170 (/TAS) P15170 (/TAS) P15170 (/TAS) P15170 (/TAS) |
|
Protein methylation GO:0006479
The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
|
4 | P15170 (/IDA) P15170 (/IDA) P15170 (/IDA) P15170 (/IDA) |
|
Translational termination GO:0006415
The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
|
3 | M9PD08 (/IMP) P91944 (/IMP) Q9VK85 (/IMP) |
|
Translational termination GO:0006415
The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
|
3 | M9PD08 (/ISS) P91944 (/ISS) Q9VK85 (/ISS) |
|
Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288
A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.
|
2 | P05453 (/IMP) P05453 (/IMP) |
|
Translational termination GO:0006415
The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
|
2 | P05453 (/IDA) P05453 (/IDA) |
|
Translational termination GO:0006415
The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
|
2 | P05453 (/TAS) P05453 (/TAS) |
|
Vasculature development GO:0001944
The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
|
1 | Q7T358 (/IMP) |
|
Cytoplasmic translational termination GO:0002184
The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon.
|
1 | O74718 (/IGI) |
|
Translational termination GO:0006415
The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
|
1 | Q59YE8 (/IGI) |
|
Protein methylation GO:0006479
The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
|
1 | Q8R050 (/ISO) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
7 | P05453 (/TAS) P05453 (/TAS) P15170 (/TAS) P15170 (/TAS) P15170 (/TAS) P15170 (/TAS) Q8IYD1 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
6 | M9PD08 (/HDA) O74718 (/HDA) P05453 (/HDA) P05453 (/HDA) P91944 (/HDA) Q9VK85 (/HDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | M9PD08 (/ISS) P91944 (/ISS) Q9VK85 (/ISS) |
|
Translation release factor complex GO:0018444
A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome.
|
3 | O74718 (/IDA) P05453 (/IDA) P05453 (/IDA) |
|
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
2 | P05453 (/IDA) P05453 (/IDA) |
|
Translation release factor complex GO:0018444
A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome.
|
1 | O74718 (/IMP) |
|
Translation release factor complex GO:0018444
A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome.
|
1 | O74718 (/IPI) |
|
Cytosolic ribosome GO:0022626
A ribosome located in the cytosol.
|
1 | Q59YE8 (/IDA) |