The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 207: Protein CBR-LIN-10, isoform a

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
5 E1JJN6 (/IPI) M9PF12 (/IPI) Q9GQQ6 (/IPI) Q9VX41 (/IPI) X2JE74 (/IPI)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 O17583 (/IPI) Q9GQQ6 (/IPI) Q9VX41 (/IPI) Q9W2S5 (/IPI)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
1 O17583 (/IPI)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein localization to membrane GO:0072657
A process in which a protein is transported to, or maintained in, a specific location in a membrane.
9 E1JJN6 (/IMP) M9PF12 (/IMP) M9PGU7 (/IMP) Q5BI79 (/IMP) Q9GQQ6 (/IMP) Q9VX41 (/IMP) Q9W2S5 (/IMP) X2JB44 (/IMP) X2JE74 (/IMP)
Establishment or maintenance of cell polarity GO:0007163
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
5 E1JJN6 (/NAS) M9PF12 (/NAS) Q9GQQ6 (/NAS) Q9VX41 (/NAS) X2JE74 (/NAS)
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
5 E1JJN6 (/NAS) M9PF12 (/NAS) Q9GQQ6 (/NAS) Q9VX41 (/NAS) X2JE74 (/NAS)
Synaptic vesicle targeting GO:0016080
The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces.
5 E1JJN6 (/NAS) M9PF12 (/NAS) Q9GQQ6 (/NAS) Q9VX41 (/NAS) X2JE74 (/NAS)
Synaptic vesicle docking GO:0016081
The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process.
5 E1JJN6 (/NAS) M9PF12 (/NAS) Q9GQQ6 (/NAS) Q9VX41 (/NAS) X2JE74 (/NAS)
Compound eye development GO:0048749
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.
5 E1JJN6 (/IMP) M9PF12 (/IMP) Q9GQQ6 (/IMP) Q9VX41 (/IMP) X2JE74 (/IMP)
Neuron-neuron synaptic transmission GO:0007270
The process of synaptic transmission from a neuron to another neuron across a synapse.
1 O17583 (/IMP)
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
1 O17583 (/IDA)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 O17583 (/IMP)
Positive regulation of vulval development GO:0040026
Any process that activates or increases the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
1 O17583 (/IMP)
Regulation of backward locomotion GO:0043058
Any process that modulates the speed, mechanical force, or rhythm of the posterior movement of an organism.
1 O17583 (/IGI)
Sensory perception of touch GO:0050975
The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach).
1 O17583 (/IMP)
Receptor localization to synapse GO:0097120
Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
1 O17583 (/IMP)
Protein localization to early endosome GO:1902946
A process in which a protein is transported to, or maintained in, a location within an early endosome.
1 O17583 (/IMP)
Protein localization to basolateral plasma membrane GO:1903361
Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane.
1 O17583 (/IDA)
Positive regulation of backward locomotion GO:1905852
Any process that activates or increases the frequency, rate or extent of backward locomotion.
1 O17583 (/IMP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 E1JJN6 (/IDA) M9PF12 (/IDA) O17583 (/IDA) Q9GQQ6 (/IDA) Q9VX41 (/IDA) X2JE74 (/IDA)
Golgi trans cisterna GO:0000138
The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed.
1 O17583 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 O17583 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O17583 (/IDA)
Trans-Golgi network transport vesicle GO:0030140
A vesicle that mediates transport between the trans-Golgi network and other parts of the cell.
1 O17583 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 O17583 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 O17583 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 O17583 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 O17583 (/IDA)