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CATH Superfamily 2.20.70.10

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 25: E3 ubiquitin-protein ligase NEDD4-like protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
 3 Q96PU5 (/NAS) Q96PU5 (/NAS) Q96PU5 (/NAS)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
 3 Q96PU5 (/TAS) Q96PU5 (/TAS) Q96PU5 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 3 Q96PU5 (/IPI) Q96PU5 (/IPI) Q96PU5 (/IPI)
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
 3 Q96PU5 (/IDA) Q96PU5 (/IDA) Q96PU5 (/IDA)
Sodium channel regulator activity GO:0017080
Modulates the activity of a sodium channel.
 3 Q96PU5 (/IDA) Q96PU5 (/IDA) Q96PU5 (/IDA)
Potassium channel inhibitor activity GO:0019870
Stops, prevents, or reduces the activity of a potassium channel.
 3 Q96PU5 (/IDA) Q96PU5 (/IDA) Q96PU5 (/IDA)
Sodium channel inhibitor activity GO:0019871
Stops, prevents, or reduces the activity of a sodium channel.
 3 Q96PU5 (/IDA) Q96PU5 (/IDA) Q96PU5 (/IDA)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
 3 Q96PU5 (/IPI) Q96PU5 (/IPI) Q96PU5 (/IPI)

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
 3 Q96PU5 (/TAS) Q96PU5 (/TAS) Q96PU5 (/TAS)
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
 3 Q96PU5 (/TAS) Q96PU5 (/TAS) Q96PU5 (/TAS)
Regulation of membrane depolarization GO:0003254
Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive.
 3 Q96PU5 (/IDA) Q96PU5 (/IDA) Q96PU5 (/IDA)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
 3 Q96PU5 (/IDA) Q96PU5 (/IDA) Q96PU5 (/IDA)
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
 3 Q96PU5 (/NAS) Q96PU5 (/NAS) Q96PU5 (/NAS)
Cellular sodium ion homeostasis GO:0006883
Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
 3 Q96PU5 (/NAS) Q96PU5 (/NAS) Q96PU5 (/NAS)
Excretion GO:0007588
The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.
 3 Q96PU5 (/NAS) Q96PU5 (/NAS) Q96PU5 (/NAS)
Response to metal ion GO:0010038
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
 3 Q96PU5 (/IDA) Q96PU5 (/IDA) Q96PU5 (/IDA)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
 3 Q96PU5 (/IDA) Q96PU5 (/IDA) Q96PU5 (/IDA)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
 3 Q96PU5 (/IMP) Q96PU5 (/IMP) Q96PU5 (/IMP)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
 3 Q96PU5 (/NAS) Q96PU5 (/NAS) Q96PU5 (/NAS)
Viral life cycle GO:0019058
A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome.
 3 Q96PU5 (/TAS) Q96PU5 (/TAS) Q96PU5 (/TAS)
Water homeostasis GO:0030104
Any process involved in the maintenance of an internal steady state of water within an organism or cell.
 3 Q96PU5 (/NAS) Q96PU5 (/NAS) Q96PU5 (/NAS)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
 3 Q96PU5 (/IMP) Q96PU5 (/IMP) Q96PU5 (/IMP)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
 3 Q96PU5 (/TAS) Q96PU5 (/TAS) Q96PU5 (/TAS)
Regulation of ion transmembrane transport GO:0034765
Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
 3 Q96PU5 (/IDA) Q96PU5 (/IDA) Q96PU5 (/IDA)
Regulation of protein catabolic process GO:0042176
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
 3 Q96PU5 (/NAS) Q96PU5 (/NAS) Q96PU5 (/NAS)
Regulation of membrane potential GO:0042391
Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
 3 Q96PU5 (/IDA) Q96PU5 (/IDA) Q96PU5 (/IDA)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
 3 Q96PU5 (/IDA) Q96PU5 (/IDA) Q96PU5 (/IDA)
Positive regulation of endocytosis GO:0045807
Any process that activates or increases the frequency, rate or extent of endocytosis.
 3 Q96PU5 (/NAS) Q96PU5 (/NAS) Q96PU5 (/NAS)
Regulation of membrane repolarization GO:0060306
Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative.
 3 Q96PU5 (/IDA) Q96PU5 (/IDA) Q96PU5 (/IDA)
Protein K48-linked ubiquitination GO:0070936
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
 3 Q96PU5 (/IDA) Q96PU5 (/IDA) Q96PU5 (/IDA)
Ventricular cardiac muscle cell action potential GO:0086005
An action potential that occurs in a ventricular cardiac muscle cell.
 3 Q96PU5 (/ISS) Q96PU5 (/ISS) Q96PU5 (/ISS)
Regulation of potassium ion transmembrane transporter activity GO:1901016
Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity.
 3 Q96PU5 (/IDA) Q96PU5 (/IDA) Q96PU5 (/IDA)
Negative regulation of potassium ion transmembrane transporter activity GO:1901017
Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity.
 3 Q96PU5 (/IDA) Q96PU5 (/IDA) Q96PU5 (/IDA)
Negative regulation of potassium ion transmembrane transport GO:1901380
Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport.
 3 Q96PU5 (/IDA) Q96PU5 (/IDA) Q96PU5 (/IDA)
Negative regulation of sodium ion transmembrane transport GO:1902306
Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport.
 3 Q96PU5 (/IDA) Q96PU5 (/IDA) Q96PU5 (/IDA)
Positive regulation of dendrite extension GO:1903861
Any process that activates or increases the frequency, rate or extent of dendrite extension.
 3 Q96PU5 (/IDA) Q96PU5 (/IDA) Q96PU5 (/IDA)
Negative regulation of protein localization to cell surface GO:2000009
Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface.
 3 Q96PU5 (/IDA) Q96PU5 (/IDA) Q96PU5 (/IDA)
Negative regulation of sodium ion transmembrane transporter activity GO:2000650
Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity.
 3 Q96PU5 (/IDA) Q96PU5 (/IDA) Q96PU5 (/IDA)
Positive regulation of caveolin-mediated endocytosis GO:2001288
Any process that activates or increases the frequency, rate or extent of caveolin-mediated endocytosis.
 3 Q96PU5 (/ISS) Q96PU5 (/ISS) Q96PU5 (/ISS)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
 3 Q96PU5 (/TAS) Q96PU5 (/TAS) Q96PU5 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 3 Q96PU5 (/TAS) Q96PU5 (/TAS) Q96PU5 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
 3 Q96PU5 (/HDA) Q96PU5 (/HDA) Q96PU5 (/HDA)