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CATH Superfamily 2.20.100.10

Thrombospondin type-1 (TSP1) repeat

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Thrombospondin type-1 (TSP1) repeat
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
semaphorin-5A isoform X1
1839 - - 94.4
2
Unc-5 netrin receptor C
1440 - - 96.7
3
Adhesion G protein-coupled receptor B2
1020 - - 87.8
4
Adhesion G protein-coupled receptor B2
992 - - 95.3
5
ADAM metallopeptidase with thrombospondin type 1 motif 9
962 - - 94.7
6
A disintegrin and metalloproteinase with thrombospondin motifs 1
960 - - 77.5
7
Thrombospondin 1
892
3D
 3r6bA02 - 81.0
8
Unc-5 netrin receptor C
861 - - 73.4
9
ADAMTS-like protein 3 isoform A
656 - - 93.8
10
ADAM metallopeptidase with thrombospondin type 1 motif 9
468 - - 91.8
11
A disintegrin and metalloproteinase with thrombospondin motifs 3
447 - - 91.2
12
Adhesion G protein-coupled receptor B2
413 - - 81.1
13
Spondin 1a
411 - - 86.5
14
Thrombospondin type 1 domain containing 7A
288 - - 90.4
15
Thrombospondin, type I, domain containing 7A
276 - - 76.7
16
ADAMTS-like 3 isoform 1
232 - - 46.4
17
Thrombospondin type 1 domain containing 7A
225 - - 83.8
18
Thrombospondin type 1 domain containing 7A
218 - - 93.0
19
Thrombospondin type 1 domain containing 7A
216 - - 93.6
20
Thrombospondin type 1 domain containing 7A
207 - - 84.7
21
semaphorin-5B isoform X1
206 - - 94.2
22
A disintegrin and metalloproteinase with thrombospondin motifs 3
204 - - 70.2
23
Thrombospondin type-1 domain-containing protein 4
199 - - 73.3
24
Spondin-1
194
3D
 1szlA01 - 37.2
26
Spondin 1
174 - - 89.3
25
ADAMTS like 1
174 - - 76.1
27
Thrombospondin type 1 domain containing 7A
168 - - 92.5
28
R-spondin 2
158 - - 85.0
30
A disintegrin and metalloproteinase with thrombospondin motifs 3
153 - - 82.7
29
ADAM metallopeptidase with thrombospondin type 1 motif, 6
153 - - 56.9
31
Thrombospondin type 1 domain containing 7A
151 - - 81.5
32
ADAMTS-like protein 1
143 - - 24.8
33
Isthmin 1
140 - - 76.7
34
Spondin-1
122 - - 72.1
35
A disintegrin and metalloproteinase with thrombospondin motifs 12
122 - - 70.8
36
Connective tissue growth factor
Predicted
120 - - 46.0
37
Spondin 2
117 - - 76.8
38
CYR61 isoform 1
116 - - 81.0
39
thrombospondin type-1 domain-containing protein 4
114 - - 80.5
40
ADAM metallopeptidase with thrombospondin type 1 motif 9
112 - - 77.7
41
ADAMTS like 1
103 - - 41.4
42
ADAMTS like 2
100 - - 27.1
43
R-spondin 3
96 - - 76.6
44
Thrombospondin type 1 domain containing 4
94 - - 44.8
45
ADAMTS-like protein 2
92 - - 33.7
46
Cellular communication network factor 4
90 - - 81.5
47
Thrombospondin type 1 domain containing 4
88 - - 22.4
48
ADAM metallopeptidase with thrombospondin type 1 motif 8
87 - - 81.2
49
Thrombospondin type 1 domain containing 4
82 - - 34.7
50
Thrombospondin type 1 domain containing 7B
77 - - 82.2
51
Cartilage intermediate layer protein 2
76 - - 84.2
52
ADAM metallopeptidase with thrombospondin type 1 motif 6
75 - - 27.3
53
ADAMTS-like protein 2
74 - - 19.4
54
ADAMTS-like protein 2
74 - - 28.8
55
ADAMTS-like protein 4 isoform X1
73 - - 32.2
56
R-spondin 1
72 - - 68.7
57
A disintegrin and metalloproteinase with thrombospondin motifs 5
69 - - 38.7
58
Thrombospondin type 1 domain containing 4
68 - - 30.8
59
ADAM metallopeptidase with thrombospondin type 1 motif 12
65 - - 44.6
60
ADAM metallopeptidase with thrombospondin type 1 motif 17
64 - - 22.4
61
adhesion G protein-coupled receptor B1
64 - - 85.1
63
Thrombospondin type 1 domain containing 7B
62 - - 66.0
62
Thrombospondin type 1 domain containing 7B
62 - - 69.5
64
A disintegrin and metalloproteinase with thrombospondin motifs 10 preproprotein
57 - - 64.2
65
Cellular communication network factor 6
56 - - 80.4
66
A disintegrin and metalloproteinase with thrombospondin motifs 18
51 - - 71.3
67
Hemicentin 1
49 - - 90.6
68
ADAM metallopeptidase with thrombospondin type 1 motif 9
48 - - 74.7
69
Cellular communication network factor 4
46 - - 77.6
70
SCO-spondin
46 - - 42.8
71
ADAMTS like 4
44 - - 27.8
73
A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X2
43 - - 38.1
72
SCO-spondin
43 - - 40.6
74
ADAM metallopeptidase with thrombospondin type 1 motif 12
41 - - 33.0
75
ADAM metallopeptidase with thrombospondin type 1 motif 17
40 - - 28.3
76
ADAMTS-like protein 3
40 - - 76.9
78
ADAMTS like 2
39 - - 24.2
77
ADAM metallopeptidase with thrombospondin type 1 motif 12
39 - - 34.2
79
ADAM metallopeptidase with thrombospondin type 1 motif 17
38 - - 79.3
80
SCO-spondin
38 - - 93.2
81
Spondin-1
37
3D
 1vexA00 - 56.8
82
Complement component C8 beta chain
36 - - 71.9
83
ADAMTS like 3
35 - - 24.8
84
WNT1-inducible-signaling pathway protein 2 isoform X1
33 - - 88.2
85
ADAMTS like 4
32 - - 34.3
87
Complement component C6
32
3D
 4a5wB01 - 45.4
86
ADAMTS like 3
31 - - 37.7
88
A disintegrin and metalloproteinase with thrombospondin motifs 18
30 - - 57.5
89
Complement component C9
29 - - 90.8
92
ADAM metallopeptidase with thrombospondin type 1 motif 13
28 - - 35.8
91
Somatomedin B and thrombospondin type 1 domain containing
28 - - 31.0
90
A disintegrin and metalloproteinase with thrombospondin motifs 12
28 - - 42.0
93
SCO-spondin-like isoform 1
27 - - 66.6
94
ADAM metallopeptidase with thrombospondin type 1 motif, 18
27 - - 80.6
95
Circumsporozoite protein
25 - - 21.4
96
Cartilage intermediate layer protein 1
25 - - 34.4
97
ADAMTS like 5
25 - - 28.7
100
Sporozoite surface protein 2
24 - - 14.5
99
SCO-spondin
24 - - 36.2
98
A disintegrin and metalloproteinase with thrombospondin motifs 7
24 - - 53.9
101
No long nerve cord, isoform F
23 - - 12.3
102
Complement component C6
23 - - 22.6
103
SCO-spondin
22 - - 41.5
104
Papilin
22 - - 73.3
105
Circumsporozoite-and TRAP-related protein
22 - - 74.8
107
Uncharacterized protein, isoform C
21 - - 15.2
106
Spondin-1
21 - - 37.5
108
ADAM metallopeptidase with thrombospondin type 1 motif, 13
20 - - 32.8
110
Circumsporozoite-and TRAP-related protein
19 - - 8.4
109
Spondin-1
19 - - 15.9
111
ADAMTS-like protein 4 isoform X1
18 - - 45.8
113
TRAP-like protein
18 - - 10.8
112
Thrombospondin-related apical membrane protein
18 - - 0.0
114
Unc-5, isoform B
18 - - 78.2
115
Thrombospondin type-1 domain-containing protein 1
17 - - 69.3
116
Thrombospondin protein-1
17 - - 6.8
119
Circumsporozoite-and TRAP-related protein
16 - - 2.5
117
Spondin-1
16 - - 7.9
118
No long nerve cord, isoform D
16 - - 6.4
121
Lonely heart, isoform A
15 - - 13.9
120
Thrombospondin, type I, domain-containing 7Ab
15 - - 86.3
123
SCO-spondin
14 - - 39.2
122
SCO-spondin
14 - - 23.9
125
Circumsporozoite-and TRAP-related protein
13 - - 10.8
124
Spondin-1-like Protein
13 - - 59.3
126
Lonely heart, isoform A
13 - - 13.7
128
A disintegrin and metalloproteinase with thrombospondin motifs adt-2
12 - - 59.6
127
A disintegrin and metalloproteinase with thrombospondin motifs adt-2
12 - - 17.6
132
A disintegrin and metalloproteinase with thrombospondin motifs adt-2
12 - - 9.0
129
Zinc metalloproteinase dpy-31
12 - - 87.2
131
papilin isoform X3
12 - - 10.1
130
No long nerve cord, isoform A
12 - - 4.2
135
F-spondin
11 - - 52.8
140
Zinc metalloproteinase
11 - - 13.7
136
SPONdin
Extracellular matrix glycoprotein
11 - - 74.9
134
Uncharacterized protein
11 - - 45.4
141
Lonely heart, isoform A
11 - - 16.1
137
SPONdin
Extracellular matrix glycoprotein
11 - - 27.5
138
No long nerve cord, isoform A
11 - - 17.6
133
Complement factor properdin
11 - - 35.2
142
ADAM metallopeptidase with thrombospondin type 1 motif 13
11 - - 16.1
139
A disintegrin and metalloproteinase with thrombospondin motifs gon-1
11 - - 16.6
149
Protein CBR-MADD-4
10 - - 7.8
148
A disintegrin and metalloproteinase with thrombospondin motifs gon-1
10 - - 13.5
147
A disintegrin and metalloproteinase with thrombospondin motifs gon-1
10 - - 11.0
143
Complement factor properdin
10 - - 35.8
145
SPONdin
Extracellular matrix glycoprotein
10 - - 46.3
146
CBN-PPN-1 protein
10 - - 10.1
144
AGAP011765-PA
10 - - 74.0
152
SCO-spondin isoform X3
9 - - 34.4
154
GD10853
9 - - 81.3
151
SPONdin
Extracellular matrix glycoprotein
9 - - 48.4
153
A disintegrin and metalloproteinase with thrombospondin motifs adt-2
9 - - 9.0
150
GM21753
9 - - 63.8
155
Protein CBR-SPON-1
8 - - 32.4
156
GD10853
8 - - 68.7
162
Semaphorin 5C
8 - - 54.2
157
papilin isoform X5
8 - - 12.4
158
Uncharacterized protein, isoform D
8 - - 5.8
160
spondin-1
8 - - 49.8
161
F-spondin
8 - - 56.5
159
spondin-1 isoform X1
8 - - 14.4
170
Semaphorin-5c
7 - - 74.2
164
Zinc metalloproteinase
7 - - 23.4
166
Zinc metalloproteinase
7 - - 13.8
165
CCN family member 3
7 - - 16.6
169
Complement factor properdin
7 - - 44.9
163
Uncharacterized protein
7 - - 8.5
167
ADAM metallopeptidase with thrombospondin type 1 motif A, isoform B
7 - - 18.6
168
A disintegrin and metalloproteinase with thrombospondin motifs gon-1
7 - - 11.9
173
Complement C7
6 - - 92.1
171
Thrombospondin type 1 domain containing 4
6 - - 37.6
174
GD10852
6 - - 13.0
176
LOC100158609 protein
6 - - 76.9
172
Putative reeler
6 - - 45.4
175
GD10852
6 - - 12.6
179
A disintegrin and metalloproteinase with thrombospondin motifs gon-1
5 - - 8.4
180
Uncharacterized protein, isoform D
5 - - 7.3
183
Thrombospondin type-1 domain-containing protein 7A
5 - - 7.6
181
Protein CBR-MIG-6
5 - - 14.5
178
Pancreatic trypsin inhibitor
5 - - 46.8
177
SCO-spondin
5 - - 32.1
182
Thrombospondin type-1 domain-containing protein 7A
5 - - 7.0
191
Netrin receptor unc-5
4 - - 8.4
189
Uncharacterized protein
4 - - 17.4
193
Uncharacterized protein
4 - - 74.4
188
Uncharacterized protein, isoform B
4 - - 9.9
190
A disintegrin-like and metallopeptidase
reprolysin type
4 - - 7.7
187
Lonely heart, isoform A
4 - - 0.0
192
Thrombospondin type-1 domain-containing protein 7B
4 - - 40.0
184
AGAP002424-PA
4 - - 15.8
186
spondin-1-like
4 - - 2.7
185
AGAP012813-PA
4 - - 85.2
197
Thrombospondin type 1 domain containing 7A
3 - - 50.7
198
Sema domain, seven thrombospondin repeats
type 1 and type 1-like TM semaphorin
3 - - 48.1
199
Thrombospondin type 1 domain containing 7A
3 - - 42.7
194
Predicted protein
3 - - 47.6
196
Uncharacterized protein
3 - - 71.4
195
Uncharacterized protein
3 - - 50.7
233
A disintegrin and metalloproteinase with thrombospondin motifs adt-1 isoform X1
2 - - 0.0
224
A disintegrin and metalloproteinase with thrombospondin motifs gon-1
2 - - 0.0
226
A disintegrin and metalloproteinase with thrombospondin motifs gon-1
2 - - 0.0
231
plasminogen-like isoform X2
2 - - 0.0
238
Uncharacterized protein
2 - - 47.1
225
spondin-1-like
2 - - 0.0
222
SCO-spondin
2 - - 0.0
237
Thrombospondin, type I, domain-containing 7Ba
2 - - 0.0
202
Thrombospondin type-1 domain-containing protein 7B
2 - - 0.0
205
Complement factor properdin
2 - - 1.9
214
Thrombospondin type-1 domain-containing protein 7B
2 - - 0.0
216
Spondin-1-like Protein
2 - - 45.7
215
Semaphorin-5A, putative
2 - - 37.9
212
Thrombospondin type-1 domain-containing protein 7B
2 - - 0.0
230
A disintegrin and metalloproteinase with thrombospondin motifs gon-1
2 - - 0.0
206
Golgi apparatus membrane protein TVP23 homolog
2 - - 0.0
204
Complement factor properdin
2 - - 3.7
221
Metalloendopeptidase
2 - - 0.0
200
Semaphorin 5c, isoform A
2 - - 1.9
219
Uncharacterized protein
2 - - 0.0
236
A disintegrin and metalloproteinase with thrombospondin motifs adt-1 isoform X1
2 - - 0.0
223
A disintegrin and metalloproteinase with thrombospondin motifs adt-1 isoform X1
2 - - 0.0
234
Semaphorin-5A
2 - - 1.8
232
F-spondin
2 - - 4.8
227
spondin-1-like
2 - - 0.0
235
A disintegrin and metalloproteinase with thrombospondin motifs gon-1
2 - - 0.0
228
Putative salivary kunitz domain protein
2 - - 2.3
209
Thrombospondin type-1 domain-containing protein 7B
2 - - 0.0
210
Thrombospondin type-1 domain-containing protein 7B
2 - - 0.0
229
Putative semaphorin
2 - - 1.8
208
ADAM metallopeptidase with thrombospondin type 1 motif, 6
2 - - 1.7
213
Thrombospondin type-1 domain-containing protein 7B
2 - - 0.0
211
Thrombospondin type-1 domain-containing protein 7B
2 - - 2.4
207
Thrombospondin type I repeat-containing single pass transmembrane protein
2 - - 5.0
203
Complement factor properdin
2 - - 0.0
218
kielin/chordin-like protein
2 - - 46.0
220
Metalloendopeptidase
2 - - 0.0
201
Thrombospondin type-1 domain-containing protein 7B
2 - - 0.0
217
Uncharacterized protein
2 - - 45.0
253
Uncharacterized protein
1 - - 0.0
251
Uncharacterized protein
1 - - 0.0
257
Semaphorin-5c
1 - - 0.0
246
plasminogen-like
1 - - 0.0
244
Uncharacterized protein
1 - - 0.0
239
AGAP002424-PA
1 - - 0.0
242
Uncharacterized protein
1 - - 0.0
250
Uncharacterized protein
1 - - 0.0
245
Uncharacterized protein
1 - - 0.0
249
Predicted protein
1 - - 0.0
254
Uncharacterized protein
1 - - 0.0
256
Uncharacterized protein
1 - - 0.0
255
Uncharacterized protein
1 - - 0.0
240
Uncharacterized protein
1 - - 0.0
252
Predicted protein
1 - - 0.0
241
Thrombospondin type 1 domaincontaining protein
1 - - 0.0
243
Uncharacterized protein
1 - - 0.0
247
Uncharacterized protein
1 - - 0.0
248
Uncharacterized protein
1 - - 0.0
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