The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SET domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 24: Histone-lysine N-methyltransferase SETD7

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 Q8VHL1 (/IPI) Q8WTS6 (/IPI) Q8WTS6 (/IPI) Q8WTS6 (/IPI) Q8WTS6 (/IPI) Q8WTS6 (/IPI) Q8WTS6 (/IPI) Q8WTS6 (/IPI)
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
7 Q8WTS6 (/IPI) Q8WTS6 (/IPI) Q8WTS6 (/IPI) Q8WTS6 (/IPI) Q8WTS6 (/IPI) Q8WTS6 (/IPI) Q8WTS6 (/IPI)
Protein-lysine N-methyltransferase activity GO:0016279
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.
7 Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
7 Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
7 Q8WTS6 (/NAS) Q8WTS6 (/NAS) Q8WTS6 (/NAS) Q8WTS6 (/NAS) Q8WTS6 (/NAS) Q8WTS6 (/NAS) Q8WTS6 (/NAS)
Protein-lysine N-methyltransferase activity GO:0016279
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.
4 Q4QQN5 (/ISS) Q6DHG0 (/ISS) Q7Z0G7 (/ISS) Q8VHL1 (/ISS)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
4 Q4QQN5 (/ISS) Q6DHG0 (/ISS) Q7Z0G7 (/ISS) Q8VHL1 (/ISS)
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
1 Q8VHL1 (/ISO)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 D4ADE5 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q8VHL1 (/ISO)
Protein-lysine N-methyltransferase activity GO:0016279
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.
1 Q8VHL1 (/ISO)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
1 Q8VHL1 (/ISO)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
7 Q8WTS6 (/NAS) Q8WTS6 (/NAS) Q8WTS6 (/NAS) Q8WTS6 (/NAS) Q8WTS6 (/NAS) Q8WTS6 (/NAS) Q8WTS6 (/NAS)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
7 Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA)
Peptidyl-lysine monomethylation GO:0018026
The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine.
7 Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA)
Peptidyl-lysine dimethylation GO:0018027
The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine.
7 Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA)
Heterochromatin organization GO:0070828
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin.
7 Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA)
Peptidyl-lysine monomethylation GO:0018026
The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine.
4 Q4QQN5 (/ISS) Q6DHG0 (/ISS) Q7Z0G7 (/ISS) Q8VHL1 (/ISS)
Peptidyl-lysine dimethylation GO:0018027
The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine.
4 Q4QQN5 (/ISS) Q6DHG0 (/ISS) Q7Z0G7 (/ISS) Q8VHL1 (/ISS)
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 Q6DHG0 (/IGI)
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 Q6DHG0 (/IMP)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
1 Q8VHL1 (/ISO)
Peptidyl-lysine methylation GO:0018022
The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative.
1 Q8VHL1 (/IDA)
Peptidyl-lysine monomethylation GO:0018026
The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine.
1 Q8VHL1 (/ISO)
Peptidyl-lysine dimethylation GO:0018027
The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine.
1 Q8VHL1 (/ISO)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 D4ADE5 (/IEP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 D4ADE5 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8VHL1 (/ISO)
Regulation of histone H3-K9 methylation GO:0051570
Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3.
1 Q8VHL1 (/IDA)
Heterochromatin organization GO:0070828
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin.
1 Q8VHL1 (/IMP)
Heterochromatin organization GO:0070828
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin.
1 Q8VHL1 (/ISO)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
7 Q8WTS6 (/TAS) Q8WTS6 (/TAS) Q8WTS6 (/TAS) Q8WTS6 (/TAS) Q8WTS6 (/TAS) Q8WTS6 (/TAS) Q8WTS6 (/TAS)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
7 Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA) Q8WTS6 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 D4ADE5 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8VHL1 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q8VHL1 (/ISO)