The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Kelch-type beta propeller
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13: Kelch-like family member 7

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
13 Q8IXQ5 (/IPI) Q8IXQ5 (/IPI) Q8IXQ5 (/IPI) Q8IXQ5 (/IPI) Q8IXQ5 (/IPI) Q8IXQ5 (/IPI) Q8IXQ5 (/IPI) Q8IXQ5 (/IPI) Q8IXQ5 (/IPI) Q8IXQ5 (/IPI)
(3 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
13 Q8IXQ5 (/IPI) Q8IXQ5 (/IPI) Q8IXQ5 (/IPI) Q8IXQ5 (/IPI) Q8IXQ5 (/IPI) Q8IXQ5 (/IPI) Q8IXQ5 (/IPI) Q8IXQ5 (/IPI) Q8IXQ5 (/IPI) Q8IXQ5 (/IPI)
(3 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
13 Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA)
(3 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 Q5XHZ6 (/ISS) Q5ZI33 (/ISS) Q8BUL5 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q8BUL5 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q8BUL5 (/ISO)

There are 3 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
13 Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA)
(3 more)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
3 Q5XHZ6 (/ISS) Q5ZI33 (/ISS) Q8BUL5 (/ISS)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
1 Q8BUL5 (/ISO)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
13 Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA)
(3 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
13 Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA)
(3 more)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
13 Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA)
(3 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
13 Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA)
(3 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
13 Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA)
(3 more)
Cul3-RING ubiquitin ligase complex GO:0031463
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
13 Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA)
(3 more)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
13 Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA) Q8IXQ5 (/IDA)
(3 more)
Cul3-RING ubiquitin ligase complex GO:0031463
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
3 Q5XHZ6 (/ISS) Q5ZI33 (/ISS) Q8BUL5 (/ISS)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
3 Q5XHZ6 (/ISS) Q5ZI33 (/ISS) Q8BUL5 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8BUL5 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q8BUL5 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q8BUL5 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8BUL5 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8BUL5 (/ISO)
Cul3-RING ubiquitin ligase complex GO:0031463
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
1 Q8BUL5 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q8BUL5 (/ISO)