The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Laminin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 512: Laminin subunit alpha 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
1 Q60675 (/RCA)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Digestive tract mesoderm development GO:0007502
The process whose specific outcome is the progression of the digestive tract mesoderm over time, from its formation to the mature structure. The digestive tract mesoderm is portion of the middle layer of the three primary germ layers of the embryo which will go on to form part of the digestive tract of the organism.
4 M9MRU0 (/IMP) Q8IP51 (/IMP) Q9XZC9 (/IMP) R9PY40 (/IMP)
Gonad development GO:0008406
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
4 M9MRU0 (/IMP) Q8IP51 (/IMP) Q9XZC9 (/IMP) R9PY40 (/IMP)
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
3 A0A0R4II20 (/IGI) Q2TJF6 (/IGI) Q45H72 (/IGI)
Eye development GO:0001654
The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
3 A0A0R4II20 (/IMP) Q2TJF6 (/IMP) Q45H72 (/IMP)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
3 A0A0R4II20 (/IGI) Q2TJF6 (/IGI) Q45H72 (/IGI)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
3 A0A0R4II20 (/IMP) Q2TJF6 (/IMP) Q45H72 (/IMP)
Lens development in camera-type eye GO:0002088
The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
3 A0A0R4II20 (/IMP) Q2TJF6 (/IMP) Q45H72 (/IMP)
Establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis GO:0003412
The specification and formation of the apicobasal polarity of an epithelial cell that contributes to the shaping of a camera-type eye.
3 A0A0R4II20 (/IMP) Q2TJF6 (/IMP) Q45H72 (/IMP)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
3 A0A0R4II20 (/IMP) Q2TJF6 (/IMP) Q45H72 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
3 A0A0R4II20 (/IMP) Q2TJF6 (/IMP) Q45H72 (/IMP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
3 A0A0R4II20 (/IMP) Q2TJF6 (/IMP) Q45H72 (/IMP)
Optokinetic behavior GO:0007634
The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus.
3 A0A0R4II20 (/IMP) Q2TJF6 (/IMP) Q45H72 (/IMP)
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
3 A0A0R4II20 (/IMP) Q2TJF6 (/IMP) Q45H72 (/IMP)
Notochord development GO:0030903
The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.
3 A0A0R4II20 (/IMP) Q2TJF6 (/IMP) Q45H72 (/IMP)
Retinal ganglion cell axon guidance GO:0031290
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
3 A0A0R4II20 (/IMP) Q2TJF6 (/IMP) Q45H72 (/IMP)
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
3 A0A0R4II20 (/IMP) Q2TJF6 (/IMP) Q45H72 (/IMP)
Blood vessel morphogenesis GO:0048514
The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
3 A0A0R4II20 (/IGI) Q2TJF6 (/IGI) Q45H72 (/IGI)
Camera-type eye morphogenesis GO:0048593
The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
3 A0A0R4II20 (/IMP) Q2TJF6 (/IMP) Q45H72 (/IMP)
Brain morphogenesis GO:0048854
The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
3 A0A0R4II20 (/IMP) Q2TJF6 (/IMP) Q45H72 (/IMP)
Notochord cell differentiation GO:0060034
The process in which relatively unspecialized cells acquire specialized structural and/or functional features cells that make up the notochord. Differentiation includes the processes involved in commitment of a cell to a notochord cell fate.
3 A0A0R4II20 (/IMP) Q2TJF6 (/IMP) Q45H72 (/IMP)
Notochord cell development GO:0060035
The process whose specific outcome is the progression of a notochord cell over time, from its formation to its mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
3 A0A0R4II20 (/IMP) Q2TJF6 (/IMP) Q45H72 (/IMP)
Somite development GO:0061053
The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
3 A0A0R4II20 (/IMP) Q2TJF6 (/IMP) Q45H72 (/IMP)
Cornea development in camera-type eye GO:0061303
The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye.
3 A0A0R4II20 (/IMP) Q2TJF6 (/IMP) Q45H72 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 Q60675 (/IGI)
Epithelial structure maintenance GO:0010669
A tissue homeostatic process required for the maintenance of epithelial structure.
1 Q8IP51 (/IMP)
Positive regulation of synaptic transmission, cholinergic GO:0032224
Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.
1 Q60675 (/IMP)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
4 A0A1D5PP29 (/IDA) G5ECE3 (/IDA) Q60675 (/IDA) Q8IP51 (/IDA)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
4 M9MRU0 (/ISS) Q8IP51 (/ISS) Q9XZC9 (/ISS) R9PY40 (/ISS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q60675 (/TAS)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
1 Q60675 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q60675 (/HDA)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
1 A0A1D5PP29 (/IDA)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
1 Q60675 (/IDA)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
1 Q60675 (/IDA)
Synaptic cleft GO:0043083
The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released.
1 Q60675 (/IDA)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
1 Q60675 (/ISO)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
1 Q60675 (/HDA)