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CATH Superfamily 2.10.25.10

Laminin

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Laminin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 452: thyroid peroxidase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Iodide peroxidase. [EC: 1.11.1.8]
(1) 2 iodide + H(2)O(2) + 2 H(+) = diiodine + 2 H(2)O. (2) [Thyroglobulin]-L-tyrosine + iodide + H(2)O(2) = [thyroglobulin]-3- iodo-L-tyrosine + 2 H(2)O. (3) [Thyroglobulin]-3-iodo-L-tyrosine + iodide + H(2)O(2) = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H(2)O. (4) 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H(2)O(2) = [thyroglobulin]- L-thyroxine + [thyroglobulin]-aminoacrylate + 2 H(2)O. (5) [Thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L- tyrosine + H(2)O(2) = [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + 2 H(2)O.
  • Thyroid peroxidase catalyzes the biosynthesis of the thyroid hormones L-thyroxine and triiodo-L-thyronine.
  • It catalyzes both the iodination of tyrosine residues in thyroglobulin (forming mono- and di-iodinated forms) and their coupling to form either L-thyroxine or triiodo-L-thyronine.
 5 P07202 P09933 P14650 P35419 Q8HYB7