The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Laminin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 407: Laminin subunit alpha-3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
1 Q21313 (/ISS)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Basement membrane organization GO:0071711
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane.
5 C1P640 (/IMP) C1P641 (/IMP) G5EEV6 (/IMP) Q00174 (/IMP) Q21313 (/IMP)
Reproduction GO:0000003
The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.
4 C1P640 (/IMP) C1P641 (/IMP) G5EEV6 (/IMP) Q21313 (/IMP)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
4 A0A0R4IZA6 (/IMP) B2RZI0 (/IMP) F1R5K7 (/IMP) F1RCP6 (/IMP)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
4 C1P640 (/IMP) C1P641 (/IMP) G5EEV6 (/IMP) Q21313 (/IMP)
Endothelial cell proliferation GO:0001935
The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
4 A0A0R4IZA6 (/IMP) B2RZI0 (/IMP) F1R5K7 (/IMP) F1RCP6 (/IMP)
Axonal defasciculation GO:0007414
Separation of axons away from a bundle of axons known as a fascicle.
4 C1P640 (/IMP) C1P641 (/IMP) G5EEV6 (/IMP) Q21313 (/IMP)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
4 A0A0R4IZA6 (/IMP) B2RZI0 (/IMP) F1R5K7 (/IMP) F1RCP6 (/IMP)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
4 C1P640 (/IMP) C1P641 (/IMP) G5EEV6 (/IMP) Q21313 (/IMP)
Positive regulation of endopeptidase activity GO:0010950
Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
4 C1P640 (/IMP) C1P641 (/IMP) G5EEV6 (/IMP) Q21313 (/IMP)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
4 C1P640 (/IMP) C1P641 (/IMP) G5EEV6 (/IMP) Q21313 (/IMP)
Positive regulation of locomotion GO:0040017
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
4 C1P640 (/IMP) C1P641 (/IMP) G5EEV6 (/IMP) Q21313 (/IMP)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
4 C1P640 (/IMP) C1P641 (/IMP) G5EEV6 (/IMP) Q21313 (/IMP)
Blood vessel endothelial cell migration GO:0043534
The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis.
4 A0A0R4IZA6 (/IMP) B2RZI0 (/IMP) F1R5K7 (/IMP) F1RCP6 (/IMP)
Response to misfolded protein GO:0051788
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus.
4 C1P640 (/IMP) C1P641 (/IMP) G5EEV6 (/IMP) Q21313 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 Q00174 (/IMP)
Mesoderm development GO:0007498
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
1 Q00174 (/IEP)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 Q00174 (/IMP)
Female meiosis chromosome segregation GO:0016321
The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female.
1 Q00174 (/HMP)
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
1 Q00174 (/IDA)
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
1 Q00174 (/IDA)
Dorsal trunk growth, open tracheal system GO:0035001
Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system.
1 Q00174 (/IMP)
Melanotic encapsulation of foreign target GO:0035011
Formation of a multilayered, melanized sheath of cells around a foreign invader.
1 Q00174 (/IMP)
Negative regulation of synaptic growth at neuromuscular junction GO:0045886
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction.
1 Q00174 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
5 C1P640 (/IDA) C1P641 (/IDA) G5EEV6 (/IDA) Q00174 (/IDA) Q21313 (/IDA)
Presynaptic periactive zone GO:0036062
A region that surrounds the active zone of the presynaptic plasma membrane, and is specialized for the control of synaptic development.
1 Q00174 (/IDA)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
1 Q00174 (/HDA)