The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Laminin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 266: Urokinase-type plasminogen activator

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P00749 (/IPI) P00749 (/IPI) P06869 (/IPI) P06869 (/IPI)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2 P00749 (/TAS) P00749 (/TAS)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
2 P06869 (/ISO) P06869 (/ISO)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
1 P29598 (/IDA)

There are 53 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
2 P06869 (/ISO) P06869 (/ISO)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 P06869 (/IMP) P06869 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
2 P00749 (/TAS) P00749 (/TAS)
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
2 P00749 (/TAS) P00749 (/TAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2 P00749 (/TAS) P00749 (/TAS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 P06869 (/ISO) P06869 (/ISO)
Regulation of signaling receptor activity GO:0010469
Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity.
2 P00749 (/IDA) P00749 (/IDA)
Regulation of signaling receptor activity GO:0010469
Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity.
2 P06869 (/ISO) P06869 (/ISO)
Smooth muscle cell migration GO:0014909
The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism.
2 P06869 (/IMP) P06869 (/IMP)
Regulation of smooth muscle cell migration GO:0014910
Any process that modulates the frequency, rate or extent of smooth muscle cell migration.
2 P00749 (/IDA) P00749 (/IDA)
Regulation of smooth muscle cell migration GO:0014910
Any process that modulates the frequency, rate or extent of smooth muscle cell migration.
2 P06869 (/ISO) P06869 (/ISO)
Positive regulation of smooth muscle cell migration GO:0014911
Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.
2 P06869 (/ISO) P06869 (/ISO)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
2 P00749 (/IDA) P00749 (/IDA)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
2 P06869 (/ISO) P06869 (/ISO)
Plasminogen activation GO:0031639
The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.
2 P00749 (/IDA) P00749 (/IDA)
Plasminogen activation GO:0031639
The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.
2 P06869 (/ISO) P06869 (/ISO)
Regulation of cell adhesion mediated by integrin GO:0033628
Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin.
2 P00749 (/IDA) P00749 (/IDA)
Regulation of cell adhesion mediated by integrin GO:0033628
Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin.
2 P06869 (/ISO) P06869 (/ISO)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
2 P06869 (/ISO) P06869 (/ISO)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
2 P06869 (/IGI) P06869 (/IGI)
Fibrinolysis GO:0042730
A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin.
2 P06869 (/IMP) P06869 (/IMP)
Fibrinolysis GO:0042730
A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin.
2 P00749 (/TAS) P00749 (/TAS)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
2 P00749 (/TAS) P00749 (/TAS)
Skeletal muscle tissue regeneration GO:0043403
The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.
2 P06869 (/ISO) P06869 (/ISO)
Positive regulation of ovulation GO:0060279
Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary.
2 P06869 (/ISO) P06869 (/ISO)
Regulation of wound healing GO:0061041
Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
2 P00749 (/IC) P00749 (/IC)
Neuron death GO:0070997
The process of cell death in a neuron.
2 P06869 (/ISO) P06869 (/ISO)
Regulation of smooth muscle cell-matrix adhesion GO:2000097
Any process that modulates the frequency, rate or extent of smooth muscle cell-matrix adhesion.
2 P00749 (/IDA) P00749 (/IDA)
Regulation of smooth muscle cell-matrix adhesion GO:2000097
Any process that modulates the frequency, rate or extent of smooth muscle cell-matrix adhesion.
2 P06869 (/ISO) P06869 (/ISO)
Regulation of hepatocyte proliferation GO:2000345
Any process that modulates the frequency, rate or extent of hepatocyte proliferation.
2 P06869 (/ISO) P06869 (/ISO)
Positive regulation of reactive oxygen species metabolic process GO:2000379
Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.
2 P06869 (/ISO) P06869 (/ISO)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
1 P29598 (/IMP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 P29598 (/IEP)
Embryo implantation GO:0007566
Attachment of the blastocyst to the uterine lining.
1 P29598 (/IEP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P29598 (/IMP)
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
1 P29598 (/IEP)
Positive regulation of smooth muscle cell migration GO:0014911
Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.
1 P29598 (/IMP)
Response to hepatocyte growth factor GO:0035728
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus.
1 P29598 (/IEP)
Cellular response to hepatocyte growth factor stimulus GO:0035729
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus.
1 P29598 (/IEP)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
1 P29598 (/IEP)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
1 P29598 (/IMP)
Skeletal muscle tissue regeneration GO:0043403
The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.
1 P29598 (/IMP)
Response to hyperoxia GO:0055093
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.
1 P29598 (/IEP)
Positive regulation of ovulation GO:0060279
Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary.
1 P29598 (/IMP)
Neuron death GO:0070997
The process of cell death in a neuron.
1 P29598 (/IMP)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P29598 (/IEP)
Cellular response to organic substance GO:0071310
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
1 P29598 (/IEP)
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 P29598 (/IEP)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P29598 (/IEP)
Cellular response to fluid shear stress GO:0071498
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
1 P29598 (/IEP)
Cellular response to staurosporine GO:0072734
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus.
1 P29598 (/IEP)
Regulation of hepatocyte proliferation GO:2000345
Any process that modulates the frequency, rate or extent of hepatocyte proliferation.
1 P29598 (/IMP)
Positive regulation of reactive oxygen species metabolic process GO:2000379
Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.
1 P29598 (/IDA)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
5 P00749 (/IDA) P00749 (/IDA) P29598 (/IDA) Q05589 (/IDA) Q9TVA8 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P00749 (/TAS) P00749 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P06869 (/ISO) P06869 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P00749 (/TAS) P00749 (/TAS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
2 P00749 (/HDA) P00749 (/HDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 P00749 (/IDA) P00749 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 P06869 (/ISO) P06869 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P06869 (/ISO) P06869 (/ISO)
Specific granule membrane GO:0035579
The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
2 P00749 (/TAS) P00749 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P00749 (/HDA) P00749 (/HDA)
Tertiary granule membrane GO:0070821
The lipid bilayer surrounding a tertiary granule.
2 P00749 (/TAS) P00749 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P29598 (/IDA)