The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cysteine Rich Protein
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 61: Testin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
63 A0M8R4 (/ISS) A0M8R4 (/ISS) A0M8R4 (/ISS) A0M8R4 (/ISS) A0M8R4 (/ISS) A0M8R4 (/ISS) A0M8S5 (/ISS) A0M8S5 (/ISS) A0M8U6 (/ISS) P47226 (/ISS)
(53 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 Q2LAP6 (/IPI) Q9UGI8 (/IPI) Q9UGI8 (/IPI) Q9UGI8 (/IPI) Q9UGI8 (/IPI) Q9UGI8 (/IPI) Q9UGI8 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
6 Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
6 Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
6 Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 P47226 (/ISO)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
58 A0M8R4 (/ISS) A0M8R4 (/ISS) A0M8R4 (/ISS) A0M8R4 (/ISS) A0M8R4 (/ISS) A0M8R4 (/ISS) A0M8S5 (/ISS) A0M8S5 (/ISS) A0M8U6 (/ISS) P47226 (/ISS)
(48 more)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
6 Q9UGI8 (/IMP) Q9UGI8 (/IMP) Q9UGI8 (/IMP) Q9UGI8 (/IMP) Q9UGI8 (/IMP) Q9UGI8 (/IMP)
Neural crest cell migration GO:0001755
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
2 Q7ZXE9 (/IMP) Q7ZXE9 (/IMP)
Neural crest cell migration GO:0001755
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
1 Q6DIR5 (/ISS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 P47226 (/ISO)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
1 Q9Y423 (/IMP)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
62 A0M8R4 (/ISS) A0M8R4 (/ISS) A0M8R4 (/ISS) A0M8R4 (/ISS) A0M8R4 (/ISS) A0M8R4 (/ISS) A0M8S5 (/ISS) A0M8S5 (/ISS) A0M8U6 (/ISS) Q00PK1 (/ISS)
(52 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
12 A4D0U5 (/IDA) A4D0U5 (/IDA) A4D0U5 (/IDA) A4D0U5 (/IDA) A4D0U5 (/IDA) A4D0U5 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA)
(2 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
12 A4D0U5 (/IDA) A4D0U5 (/IDA) A4D0U5 (/IDA) A4D0U5 (/IDA) A4D0U5 (/IDA) A4D0U5 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA)
(2 more)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
12 A4D0U5 (/IDA) A4D0U5 (/IDA) A4D0U5 (/IDA) A4D0U5 (/IDA) A4D0U5 (/IDA) A4D0U5 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA)
(2 more)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
12 A4D0U5 (/IDA) A4D0U5 (/IDA) A4D0U5 (/IDA) A4D0U5 (/IDA) A4D0U5 (/IDA) A4D0U5 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA)
(2 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
6 Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA) Q9UGI8 (/HDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
6 Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA) Q9UGI8 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 A1ZAT5 (/IDA) P47226 (/IDA) Q8T0B0 (/IDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
2 Q7ZXE9 (/IDA) Q7ZXE9 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
2 A1ZAT5 (/IDA) Q8T0B0 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P47226 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P47226 (/ISO)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 P47226 (/ISO)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
1 Q6DIR5 (/ISS)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
1 P47226 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P47226 (/ISO)