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CATH Superfamily 1.50.10.20

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Terpene cyclase/mutase family member

There are 21 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Beta-amyrin synthase. [EC: 5.4.99.39]
(3S)-2,3-epoxy-2,3-dihydrosqualene = beta-amyrin.
  • Some organism possess a monofunctional beta-amyrin synthase, other have a multifunctional enzyme that also catalyzes the synthesis of alpha-amyrin (EC 5.4.99.40) or lupeol (EC 5.4.99.41).
  • Formerly EC 5.4.99.n1.
 11 A0A178WBX1 A0A178WBX1 B6EXY6 B6EXY6 E7DN63 E7DN64 O82140 O82146 Q8RWT0 Q8W3Z1
(1 more...)
Cycloartenol synthase. [EC: 5.4.99.8]
(3S)-2,3-epoxy-2,3-dihydrosqualene = cycloartenol.
    		 8 A0A125SXN3 E2IUB0 O82139 P38605 Q2XPU6 Q55D85 Q6BE25 Q9SLP9
    Lanosterol synthase. [EC: 5.4.99.7]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol.
    • Formerly EC 1.14.1.3 and EC 1.99.1.13.
    		 7 P48449 P48450 P84466 Q04782 Q10231 Q1G1A4 Q8BLN5
    Protostadienol synthase. [EC: 5.4.99.32]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = (17Z)-protosta-17(20),24-dien-3- beta-ol.
    • (17Z)-protosta-17(20),24-dien-3-beta-ol is a precursor of the steroidal antibiotic helvolic acid.
    		 5 A1CVK0 B0Y5B4 B0Y5B4 Q4WR16 Q4WR16
    Lupeol synthase. [EC: 5.4.99.41]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = lupeol.
    • Also forms some beta-amyrin.
    • The recombinant enzyme from Arabidopsis thaliana gives a 1:1 mixture of lupeol and lupan-3-beta,20-diol with small amounts of beta-amyrin, germanicol, taraxasterol and psi-taraxasterol.
    • See EC 4.2.1.128.
    • Formerly EC 5.4.99.n2.
    		 4 Q2XPU7 Q8RWT0 Q8W3Z2 Q9C5M3
    Alpha-amyrin synthase. [EC: 5.4.99.40]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = alpha-amyrin.
    • A multifunctional enzyme which produces both alpha- and beta-amyrin (see EC 5.4.99.39).
    		 2 E7DN64 Q8RWT0
    Taraxerol synthase. [EC: 5.4.99.35]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = taraxerol.
    • The enzyme gives taraxerol, beta-amyrin and lupeol in the ratio 70:17:13.
    		 1 E2IUA6
    Alpha-seco-amyrin synthase. [EC: 5.4.99.52]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = alpha-seco-amyrin.
    • The enzyme from Arabidopsis thaliana is multifunctional and produces about equal amounts of alpha- and beta-seco-amyrin.
    • See EC 5.4.99.54.
    		 1 Q9SYN1
    Beta-seco-amyrin synthase. [EC: 5.4.99.54]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = beta-seco-amyrin.
    • The enzyme from Arabidopsis thaliana is multifunctional and produces about equal amounts of alpha- and beta-seco-amyrin.
    • See EC 5.4.99.52.
    		 1 Q9SYN1
    Shionone synthase. [EC: 5.4.99.46]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = shionone.
    • The enzyme gives traces of four other triterpenoids.
    		 1 F8WQD0
    Delta-amyrin synthase. [EC: 5.4.99.55]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = delta-amyrin.
    • The enzyme from tomato (Solanum lycopersicum) gives 48% delta-amyrin, 18% alpha-amyrin, 13% beta-amyrin and traces of three or four other triterpenoid alcohols.
    • See also EC 5.4.99.40 and EC 5.4.99.39.
    		 1 E7DN64
    Tirucalladienol synthase. [EC: 5.4.99.56]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = tirucalla-7,24-dien-3-beta-ol.
    • The product from Arabidopsis thaliana is 85% tirucalla-7,24-dien-3- beta-ol with trace amounts of other triterpenoids.
    		 1 Q9LVY2
    Lupan-3-beta,20-diol synthase. [EC: 4.2.1.128]
    Lupan-3-beta,20-diol = (3S)-2,3-epoxy-2,3-dihydrosqualene + H(2)O.
    • The reaction occurs in the reverse direction.
    • The recombinant enzyme from Arabidopsis thaliana gives a 1:1 mixture of lupeol and lupan-3-beta,20-diol with small amounts of beta-amyrin, germanicol, taraxasterol and psi-taraxasterol.
    • See EC 5.4.99.41.
    		 1 Q9C5M3
    Baccharis oxide synthase. [EC: 5.4.99.51]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = baccharis oxide.
    • The enzyme from Stevia rebaudiana also gives traces of other triterpenoids.
    		 1 B9X0J1
    Marneral synthase. [EC: 5.4.99.53]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = marneral.
    • Marneral is a triterpenoid formed by Grob fragmentation of the A ring of 2,3-epoxy-2,3-dihydrosqualene during cyclization.
    		 1 Q9FJV8
    Pre-alpha-onocerin synthase. [EC: 5.4.99.65]
    (3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene = pre-alpha- onocerin.
    • Isolated from the plant Lycopodium clavatum.
    • The enzyme does not act on (3S)-2,3-epoxy-2,3-dihydrosqualene and does not form any alpha-onocerin.
    		 1 A0A125SXN1
    Thalianol synthase. [EC: 5.4.99.31]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = thalianol.
      		 1 Q9FI37
      Baruol synthase. [EC: 5.4.99.57]
      (3S)-2,3-epoxy-2,3-dihydrosqualene = baruol.
      • The enzyme from Arabidopsis thaliana also produces traces of 22 other triterpenoids.
      		 1 O23390
      Arabidiol synthase. [EC: 4.2.1.124]
      Arabidiol = (3S)-2,3-epoxy-2,3-dihydrosqualene + H(2)O.
      • The reaction occurs in the reverse direction.
      		 1 Q9FR95
      Cucurbitadienol synthase. [EC: 5.4.99.33]
      (3S)-2,3-epoxy-2,3-dihydrosqualene = cucurbitadienol.
        		 1 Q6BE24
        Alpha-onocerin synthase. [EC: 5.4.99.66]
        Pre-alpha-onocerin = alpha-onocerin.
        • Isolated from the plant Lycopodium clavatum.
        		 1 A0A125SXN2