The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13: Non-lysosomal glucosylceramidase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glucosylceramidase activity GO:0004348
Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.
2 Q69ZF3 (/IDA) Q9HCG7 (/IDA)
Beta-glucosidase activity GO:0008422
Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.
2 E7F5W0 (/IDA) Q9HCG7 (/IDA)
Beta-glucosidase activity GO:0008422
Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.
2 Q5M868 (/ISS) Q69ZF3 (/ISS)
Glucosyltransferase activity GO:0046527
Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.
2 Q5M868 (/ISS) Q9HCG7 (/ISS)
Steryl-beta-glucosidase activity GO:0050295
Catalysis of the reaction: cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol.
2 Q5M868 (/ISS) Q9HCG7 (/ISS)
Glucosylceramidase activity GO:0004348
Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.
1 Q69ZF3 (/ISO)
Glucosylceramidase activity GO:0004348
Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.
1 Q5M868 (/ISS)
Glucosylceramidase activity GO:0004348
Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.
1 Q9HCG7 (/TAS)
Beta-glucosidase activity GO:0008422
Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.
1 Q69ZF3 (/ISO)
Glucosyltransferase activity GO:0046527
Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.
1 Q69ZF3 (/IDA)
Steryl-beta-glucosidase activity GO:0050295
Catalysis of the reaction: cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol.
1 Q69ZF3 (/IDA)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glucosylceramide catabolic process GO:0006680
The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group.
2 Q69ZF3 (/IDA) Q9HCG7 (/IDA)
Glucosylceramide catabolic process GO:0006680
The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group.
2 Q69ZF3 (/IMP) Q9HCG7 (/IMP)
Cholesterol metabolic process GO:0008203
The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
2 Q5M868 (/ISS) Q9HCG7 (/ISS)
Central nervous system neuron development GO:0021954
The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.
2 Q5M868 (/ISS) Q69ZF3 (/ISS)
Lipid glycosylation GO:0030259
Covalent attachment of a glycosyl residue to a lipid molecule.
2 Q5M868 (/ISS) Q9HCG7 (/ISS)
Regulation of actin filament polymerization GO:0030833
Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.
2 Q5M868 (/ISS) Q9HCG7 (/ISS)
Regulation of microtubule polymerization GO:0031113
Any process that modulates the frequency, rate or extent of microtubule polymerization.
2 Q5M868 (/ISS) Q9HCG7 (/ISS)
Regulation of membrane lipid distribution GO:0097035
Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane.
2 Q5M868 (/ISS) Q9HCG7 (/ISS)
Glucosylceramide catabolic process GO:0006680
The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group.
1 Q69ZF3 (/ISO)
Glucosylceramide catabolic process GO:0006680
The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group.
1 Q5M868 (/ISS)
Glycosphingolipid metabolic process GO:0006687
The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide.
1 Q9HCG7 (/TAS)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
1 E7F5W0 (/IMP)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
1 E7F5W0 (/IMP)
Cholesterol metabolic process GO:0008203
The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
1 Q69ZF3 (/IMP)
Bile acid metabolic process GO:0008206
The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
1 Q9HCG7 (/IDA)
Bile acid metabolic process GO:0008206
The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
1 Q5M868 (/ISS)
Bile acid metabolic process GO:0008206
The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
1 Q9HCG7 (/TAS)
Glycoside catabolic process GO:0016139
The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound.
1 Q9HCG7 (/IDA)
Glycoside catabolic process GO:0016139
The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound.
1 Q69ZF3 (/ISO)
Glycoside catabolic process GO:0016139
The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound.
1 Q5M868 (/ISS)
Glycoside catabolic process GO:0016139
The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound.
1 Q9HCG7 (/NAS)
Central nervous system neuron development GO:0021954
The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.
1 Q9HCG7 (/IMP)
Central nervous system neuron development GO:0021954
The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.
1 Q69ZF3 (/ISO)
Lipid glycosylation GO:0030259
Covalent attachment of a glycosyl residue to a lipid molecule.
1 Q69ZF3 (/IDA)
Regulation of actin filament polymerization GO:0030833
Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.
1 Q69ZF3 (/IMP)
Regulation of microtubule polymerization GO:0031113
Any process that modulates the frequency, rate or extent of microtubule polymerization.
1 Q69ZF3 (/IMP)
Regulation of membrane lipid distribution GO:0097035
Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane.
1 Q69ZF3 (/IMP)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q5M868 (/ISS) Q9HCG7 (/ISS)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
2 Q5M868 (/ISS) Q9HCG7 (/ISS)
Extrinsic component of endoplasmic reticulum membrane GO:0042406
The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
2 Q5M868 (/ISS) Q9HCG7 (/ISS)
Extrinsic component of Golgi membrane GO:0090498
The component of a Golgi membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
2 Q5M868 (/ISS) Q9HCG7 (/ISS)
Smooth endoplasmic reticulum GO:0005790
The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
1 Q9HCG7 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q69ZF3 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 E7F5W0 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9HCG7 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9HCG7 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q69ZF3 (/ISO)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q5M868 (/ISS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9HCG7 (/NAS)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 Q69ZF3 (/IDA)
Extrinsic component of endoplasmic reticulum membrane GO:0042406
The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 Q69ZF3 (/IDA)
Extrinsic component of Golgi membrane GO:0090498
The component of a Golgi membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 Q69ZF3 (/IDA)