The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Tetratricopeptide repeat domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 865: Target for rapamycin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
2 Q9VK45 (/ISM) Q9VK45 (/ISM)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
2 Q9VK45 (/ISS) Q9VK45 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q9VK45 (/IPI) Q9VK45 (/IPI)
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
2 Q9VK45 (/IDA) Q9VK45 (/IDA)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
2 Q9VK45 (/IDA) Q9VK45 (/IDA)

There are 42 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
2 Q9VK45 (/IDA) Q9VK45 (/IDA)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
2 Q9VK45 (/IGI) Q9VK45 (/IGI)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 Q9VK45 (/ISS) Q9VK45 (/ISS)
Autophagy GO:0006914
The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Terminal branching, open tracheal system GO:0007430
Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Myoblast fusion GO:0007520
A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Somatic muscle development GO:0007525
The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
2 Q9VK45 (/TAS) Q9VK45 (/TAS)
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
2 Q9VK45 (/IDA) Q9VK45 (/IDA)
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Gonad development GO:0008406
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Negative regulation of macroautophagy GO:0016242
Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
2 Q9VK45 (/TAS) Q9VK45 (/TAS)
Cellular response to nutrient GO:0031670
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
2 Q9VK45 (/IDA) Q9VK45 (/IDA)
Endocytic recycling GO:0032456
The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
2 Q9VK45 (/IDA) Q9VK45 (/IDA)
Larval midgut cell programmed cell death GO:0035096
The stage-specific programmed cell death of cells of the larval midgut, during histolysis of the larval organ.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Lamellocyte differentiation GO:0035171
The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes.
2 Q9VK45 (/IDA) Q9VK45 (/IDA)
Multicellular organism growth GO:0035264
The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
TORC1 signaling GO:0038202
A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
2 Q9VK45 (/TAS) Q9VK45 (/TAS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Apical protein localization GO:0045176
Any process in which a protein is transported to, or maintained in, apical regions of the cell.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Positive regulation of cell size GO:0045793
Any process that increases cell size.
2 Q9VK45 (/IGI) Q9VK45 (/IGI)
Positive regulation of cell size GO:0045793
Any process that increases cell size.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Positive regulation of cell size GO:0045793
Any process that increases cell size.
2 Q9VK45 (/IPI) Q9VK45 (/IPI)
Positive regulation of cell size GO:0045793
Any process that increases cell size.
2 Q9VK45 (/TAS) Q9VK45 (/TAS)
Positive regulation of synaptic growth at neuromuscular junction GO:0045887
Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction.
2 Q9VK45 (/IGI) Q9VK45 (/IGI)
Positive regulation of transcription by RNA polymerase III GO:0045945
Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Positive regulation of insulin receptor signaling pathway GO:0046628
Any process that increases the frequency, rate or extent of insulin receptor signaling.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Germarium-derived cystoblast division GO:0048142
The four rounds of incomplete mitosis undergone by a cystoblast to form a 16-cell cyst of interconnected cells within a germarium. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. An example of this process is found in Drosophila melanogaster.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Germline cell cycle switching, mitotic to meiotic cell cycle GO:0051729
The process in which a germline cell switches cell cycle mode from mitotic to meiotic division.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Positive regulation of ribosome biogenesis GO:0090070
Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Negative regulation of proteasomal protein catabolic process GO:1901799
Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process.
2 Q9VK45 (/IDA) Q9VK45 (/IDA)
Positive regulation of axon guidance GO:1902669
Any process that activates or increases the frequency, rate or extent of axon guidance.
2 Q9VK45 (/IGI) Q9VK45 (/IGI)
Positive regulation of cell cycle G1/S phase transition GO:1902808
Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Regulation of terminal button organization GO:2000331
Any process that modulates the frequency, rate or extent of terminal button organization.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
Regulation of reactive oxygen species metabolic process GO:2000377
Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process.
2 Q9VK45 (/IGI) Q9VK45 (/IGI)
Regulation of response to drug GO:2001023
Any process that modulates the frequency, rate or extent of response to drug.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q9VK45 (/HDA) Q9VK45 (/HDA)
TORC1 complex GO:0031931
A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p.
2 Q9VK45 (/IMP) Q9VK45 (/IMP)
TORC1 complex GO:0031931
A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p.
2 Q9VK45 (/ISS) Q9VK45 (/ISS)
TORC2 complex GO:0031932
A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p.
2 Q9VK45 (/IDA) Q9VK45 (/IDA)
TORC2 complex GO:0031932
A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p.
2 Q9VK45 (/ISS) Q9VK45 (/ISS)