The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Tetratricopeptide repeat domain
".
FunFam 54: Pre-mRNA processing factor 6
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
5 | O94906 (/IGI) O94906 (/IGI) O94906 (/IGI) O94906 (/IGI) O94906 (/IGI) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
5 | O94906 (/HDA) O94906 (/HDA) O94906 (/HDA) O94906 (/HDA) O94906 (/HDA) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
5 | O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | O94906 (/IPI) O94906 (/IPI) O94906 (/IPI) O94906 (/IPI) O94906 (/IPI) |
|
Ribonucleoprotein complex binding GO:0043021
Interacting selectively and non-covalently with any complex of RNA and protein.
|
5 | O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) |
|
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
|
5 | O94906 (/IPI) O94906 (/IPI) O94906 (/IPI) O94906 (/IPI) O94906 (/IPI) |
There are 11 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Spliceosomal tri-snRNP complex assembly GO:0000244
The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex.
|
5 | O94906 (/IC) O94906 (/IC) O94906 (/IC) O94906 (/IC) O94906 (/IC) |
|
Spliceosomal tri-snRNP complex assembly GO:0000244
The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex.
|
5 | O94906 (/IMP) O94906 (/IMP) O94906 (/IMP) O94906 (/IMP) O94906 (/IMP) |
|
Spliceosomal complex assembly GO:0000245
The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.
|
5 | O94906 (/NAS) O94906 (/NAS) O94906 (/NAS) O94906 (/NAS) O94906 (/NAS) |
|
RNA splicing, via transesterification reactions GO:0000375
Splicing of RNA via a series of two transesterification reactions.
|
5 | O94906 (/NAS) O94906 (/NAS) O94906 (/NAS) O94906 (/NAS) O94906 (/NAS) |
|
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
|
5 | O94906 (/IC) O94906 (/IC) O94906 (/IC) O94906 (/IC) O94906 (/IC) |
|
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
|
5 | O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) |
|
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
|
5 | O94906 (/TAS) O94906 (/TAS) O94906 (/TAS) O94906 (/TAS) O94906 (/TAS) |
|
RNA localization GO:0006403
A process in which RNA is transported to, or maintained in, a specific location.
|
5 | O94906 (/IMP) O94906 (/IMP) O94906 (/IMP) O94906 (/IMP) O94906 (/IMP) |
|
RNA splicing GO:0008380
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
|
5 | O94906 (/NAS) O94906 (/NAS) O94906 (/NAS) O94906 (/NAS) O94906 (/NAS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
5 | O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) |
|
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
|
3 | Q2KJJ0 (/ISS) Q2KJJ0 (/ISS) Q5RCC2 (/ISS) |
There are 11 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
5 | O94906 (/TAS) O94906 (/TAS) O94906 (/TAS) O94906 (/TAS) O94906 (/TAS) |
|
Spliceosomal complex GO:0005681
Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
|
5 | O94906 (/NAS) O94906 (/NAS) O94906 (/NAS) O94906 (/NAS) O94906 (/NAS) |
|
U5 snRNP GO:0005682
A ribonucleoprotein complex that contains small nuclear RNA U5.
|
5 | O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
5 | O94906 (/HDA) O94906 (/HDA) O94906 (/HDA) O94906 (/HDA) O94906 (/HDA) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
5 | O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) |
|
U4/U6 x U5 tri-snRNP complex GO:0046540
A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins.
|
5 | O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) |
|
U2-type precatalytic spliceosome GO:0071005
A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.
|
5 | O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) |
|
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
|
5 | O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) O94906 (/IDA) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
3 | Q2KJJ0 (/ISS) Q2KJJ0 (/ISS) Q5RCC2 (/ISS) |
|
U2-type precatalytic spliceosome GO:0071005
A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.
|
3 | Q2KJJ0 (/ISS) Q2KJJ0 (/ISS) Q5RCC2 (/ISS) |