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CATH Superfamily 1.25.40.10

Tetratricopeptide repeat domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Tetratricopeptide repeat domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 46: Prolyl 3-hydroxylase 1

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Procollagen-proline 3-dioxygenase. [EC: 1.14.11.7]
L-proline-[procollagen] + 2-oxoglutarate + O(2) = trans-3-hydroxy-L- proline-[procollagen] + succinate + CO(2).
  • The enzyme forms a complex with protein disulfide isomerase, and is located in the endoplasmic reticulum.
  • It modifies proline residues within the procollagen peptide of certain collagen types.
  • The modification is essential for proper collagen triple helix formation.
 9 Q32P28 Q3V1T4 Q4KLM6 Q6JHU7 Q6JHU8 Q8CG70 Q8CG71 Q8IVL5 Q9R1J8