The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Leucine-rich Repeat Variant
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 23: AP-3 complex subunit beta

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
2 O00203 (/IPI) O00203 (/IPI)
GTP-dependent protein binding GO:0030742
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) when at least one of the interacting partners is in the GTP-bound state.
2 O00203 (/IPI) O00203 (/IPI)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
1 Q9Z1T1 (/ISO)
GTP-dependent protein binding GO:0030742
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) when at least one of the interacting partners is in the GTP-bound state.
1 Q9Z1T1 (/ISO)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Anterograde axonal transport GO:0008089
The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.
5 O00203 (/ISS) O00203 (/ISS) Q13367 (/ISS) Q32PG1 (/ISS) Q7YRF1 (/ISS)
Anterograde synaptic vesicle transport GO:0048490
The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse.
5 O00203 (/ISS) O00203 (/ISS) Q13367 (/ISS) Q32PG1 (/ISS) Q7YRF1 (/ISS)
Intracellular protein transport GO:0006886
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
4 O00203 (/TAS) O00203 (/TAS) Q9JME5 (/TAS) Q9Z1T1 (/TAS)
Anterograde axonal transport GO:0008089
The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.
2 Q9JME5 (/IMP) Q9Z1T1 (/IMP)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
2 Q9JME5 (/TAS) Q9Z1T1 (/TAS)
Melanosome organization GO:0032438
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.
2 O00203 (/IMP) O00203 (/IMP)
Anterograde synaptic vesicle transport GO:0048490
The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse.
2 Q9JME5 (/IMP) Q9Z1T1 (/IMP)
Protein targeting to lysosome GO:0006622
The process of directing proteins towards the lysosome using signals contained within the protein.
1 Q9Z1T1 (/IMP)
Zinc ion transport GO:0006829
The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9Z1T1 (/TAS)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
1 Q9Z1T1 (/IMP)
Synaptic vesicle budding from endosome GO:0016182
Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes.
1 Q9Z1T1 (/IDA)
Synaptic vesicle budding from endosome GO:0016182
Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes.
1 Q9Z1T1 (/IMP)
Antigen processing and presentation GO:0019882
The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
1 Q9Z1T1 (/IMP)
Melanosome organization GO:0032438
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.
1 Q9Z1T1 (/ISO)
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007
The process in which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.
1 Q9Z1T1 (/IMP)
Positive regulation of NK T cell differentiation GO:0051138
Any process that activates or increases the frequency, rate or extent of natural killer T cell differentiation.
1 Q9Z1T1 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
4 A8K586 (/HDA) O00203 (/HDA) O00203 (/HDA) Q3MNE1 (/HDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 O00203 (/TAS) O00203 (/TAS)
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
2 Q9JME5 (/TAS) Q9Z1T1 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 O00203 (/HDA) O00203 (/HDA)
Intracellular vesicle GO:0097708
Any vesicle that is part of the intracellular region.
1 Q13367 (/TAS)