The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Leucine-rich Repeat Variant
".
FunFam 1517: Formin-H
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q54N00 (/IPI) |
|
Profilin binding GO:0005522
Interacting selectively and non-covalently with profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin.
|
1 | Q54N00 (/IPI) |
|
GTP-Rho binding GO:0017049
Interacting selectively and non-covalently with the GTP-bound form of the Rho protein.
|
1 | Q54N00 (/IPI) |
|
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
|
1 | Q54N00 (/IDA) |
There are 9 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
|
1 | Q54N00 (/IMP) |
|
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
|
1 | Q54N00 (/IDA) |
|
Cortical actin cytoskeleton organization GO:0030866
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
|
1 | Q54N00 (/IGI) |
|
Pseudopodium organization GO:0031268
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement.
|
1 | Q54N00 (/IMP) |
|
Cell-substrate adhesion GO:0031589
The attachment of a cell to the underlying substrate via adhesion molecules.
|
1 | Q54N00 (/IMP) |
|
Actin nucleation GO:0045010
The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.
|
1 | Q54N00 (/IDA) |
|
Filopodium assembly GO:0046847
The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
|
1 | Q54N00 (/IMP) |
|
Cell motility GO:0048870
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
|
1 | Q54N00 (/IMP) |
|
Barbed-end actin filament uncapping GO:0051638
The removal of capping protein from the barbed (or plus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits.
|
1 | Q54N00 (/IDA) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
1 | Q54N00 (/IDA) |
|
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
1 | Q54N00 (/IDA) |
|
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
|
1 | Q54N00 (/IDA) |
|
Cell trailing edge GO:0031254
The area of a motile cell opposite to the direction of movement.
|
1 | Q54N00 (/IDA) |
|
Filopodium tip GO:0032433
The end of a filopodium distal to the body of the cell.
|
1 | Q54N00 (/IDA) |