The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Bromodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 18: nucleosome-remodeling factor subunit BPTF isoform ...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
9 A0A140LHY5 (/ISO) A2A654 (/ISO) A2A655 (/ISO) E5D6T0 (/ISO) E9Q6A7 (/ISO) Q3TMJ3 (/ISO) Q6P9L3 (/ISO) Q8C473 (/ISO) Q8VDN7 (/ISO)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
9 A0A140LHY5 (/ISO) A2A654 (/ISO) A2A655 (/ISO) E5D6T0 (/ISO) E9Q6A7 (/ISO) Q3TMJ3 (/ISO) Q6P9L3 (/ISO) Q8C473 (/ISO) Q8VDN7 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 A0A2R8Q3B9 (/IPI) E7F366 (/IPI) Q12830 (/IPI) X1WDW8 (/IPI)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
3 A0A2R8Q3B9 (/IDA) E7F366 (/IDA) X1WDW8 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
3 A0A2R8Q3B9 (/IMP) E7F366 (/IMP) X1WDW8 (/IMP)
Nuclear receptor binding GO:0016922
Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein.
2 Q9W0T1 (/IPI) Q9W0T1 (/IPI)
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
2 Q9W0T1 (/IDA) Q9W0T1 (/IDA)
Lysine-acetylated histone binding GO:0070577
Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation.
2 Q9W0T1 (/IDA) Q9W0T1 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 Q12830 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 Q12830 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 Q12830 (/IMP)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 Q6P9L3 (/ISS)

There are 34 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
9 A0A140LHY5 (/ISO) A2A654 (/ISO) A2A655 (/ISO) E5D6T0 (/ISO) E9Q6A7 (/ISO) Q3TMJ3 (/ISO) Q6P9L3 (/ISO) Q8C473 (/ISO) Q8VDN7 (/ISO)
Embryonic placenta development GO:0001892
The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
9 A0A140LHY5 (/IMP) A2A654 (/IMP) A2A655 (/IMP) E5D6T0 (/IMP) E9Q6A7 (/IMP) Q3TMJ3 (/IMP) Q6P9L3 (/IMP) Q8C473 (/IMP) Q8VDN7 (/IMP)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
9 A0A140LHY5 (/ISO) A2A654 (/ISO) A2A655 (/ISO) E5D6T0 (/ISO) E9Q6A7 (/ISO) Q3TMJ3 (/ISO) Q6P9L3 (/ISO) Q8C473 (/ISO) Q8VDN7 (/ISO)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
9 A0A140LHY5 (/ISO) A2A654 (/ISO) A2A655 (/ISO) E5D6T0 (/ISO) E9Q6A7 (/ISO) Q3TMJ3 (/ISO) Q6P9L3 (/ISO) Q8C473 (/ISO) Q8VDN7 (/ISO)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
9 A0A140LHY5 (/ISO) A2A654 (/ISO) A2A655 (/ISO) E5D6T0 (/ISO) E9Q6A7 (/ISO) Q3TMJ3 (/ISO) Q6P9L3 (/ISO) Q8C473 (/ISO) Q8VDN7 (/ISO)
Endoderm development GO:0007492
The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.
9 A0A140LHY5 (/IMP) A2A654 (/IMP) A2A655 (/IMP) E5D6T0 (/IMP) E9Q6A7 (/IMP) Q3TMJ3 (/IMP) Q6P9L3 (/IMP) Q8C473 (/IMP) Q8VDN7 (/IMP)
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
9 A0A140LHY5 (/IMP) A2A654 (/IMP) A2A655 (/IMP) E5D6T0 (/IMP) E9Q6A7 (/IMP) Q3TMJ3 (/IMP) Q6P9L3 (/IMP) Q8C473 (/IMP) Q8VDN7 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
9 A0A140LHY5 (/ISO) A2A654 (/ISO) A2A655 (/ISO) E5D6T0 (/ISO) E9Q6A7 (/ISO) Q3TMJ3 (/ISO) Q6P9L3 (/ISO) Q8C473 (/ISO) Q8VDN7 (/ISO)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
6 A0A2R8Q3B9 (/IMP) E7F366 (/IMP) Q12830 (/IMP) Q9W0T1 (/IMP) Q9W0T1 (/IMP) X1WDW8 (/IMP)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
3 A0A2R8Q3B9 (/IDA) E7F366 (/IDA) X1WDW8 (/IDA)
Nucleosome positioning GO:0016584
Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another.
3 A0A2R8Q3B9 (/IMP) E7F366 (/IMP) X1WDW8 (/IMP)
Neural plate anterior/posterior regionalization GO:0021999
The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate.
3 A0A2R8Q3B9 (/IGI) E7F366 (/IGI) X1WDW8 (/IGI)
Neural plate anterior/posterior regionalization GO:0021999
The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate.
3 A0A2R8Q3B9 (/IMP) E7F366 (/IMP) X1WDW8 (/IMP)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
2 Q9W0T1 (/IMP) Q9W0T1 (/IMP)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
2 Q9W0T1 (/IMP) Q9W0T1 (/IMP)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
2 Q9W0T1 (/IDA) Q9W0T1 (/IDA)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
2 Q9W0T1 (/IMP) Q9W0T1 (/IMP)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q9W0T1 (/IGI) Q9W0T1 (/IGI)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q9W0T1 (/IMP) Q9W0T1 (/IMP)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
2 Q9W0T1 (/IMP) Q9W0T1 (/IMP)
Pupariation GO:0035073
The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis.
2 Q9W0T1 (/IMP) Q9W0T1 (/IMP)
Ecdysone receptor-mediated signaling pathway GO:0035076
The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex.
2 Q9W0T1 (/IGI) Q9W0T1 (/IGI)
Nucleosome mobilization GO:0042766
The movement of nucleosomes along a DNA fragment.
2 Q9W0T1 (/IDA) Q9W0T1 (/IDA)
Nucleosome mobilization GO:0042766
The movement of nucleosomes along a DNA fragment.
2 Q9W0T1 (/TAS) Q9W0T1 (/TAS)
Negative regulation of innate immune response GO:0045824
Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.
2 Q9W0T1 (/IMP) Q9W0T1 (/IMP)
Negative regulation of receptor signaling pathway via JAK-STAT GO:0046426
Any process that stops, prevents, or reduces the frequency, rate or extent of a receptor signaling pathway via JAK-STAT.
2 Q9W0T1 (/IMP) Q9W0T1 (/IMP)
Spermatid differentiation GO:0048515
The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
2 Q9W0T1 (/IMP) Q9W0T1 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q12830 (/IDA)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
1 Q12830 (/IDA)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
1 Q6P9L3 (/ISS)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q6P9L3 (/ISS)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 Q12830 (/IMP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 Q6P9L3 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q12830 (/IMP)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
9 A0A140LHY5 (/ISO) A2A654 (/ISO) A2A655 (/ISO) E5D6T0 (/ISO) E9Q6A7 (/ISO) Q3TMJ3 (/ISO) Q6P9L3 (/ISO) Q8C473 (/ISO) Q8VDN7 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 A0A140LHY5 (/ISO) A2A654 (/ISO) A2A655 (/ISO) E5D6T0 (/ISO) E9Q6A7 (/ISO) Q3TMJ3 (/ISO) Q6P9L3 (/ISO) Q8C473 (/ISO) Q8VDN7 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
9 A0A140LHY5 (/ISO) A2A654 (/ISO) A2A655 (/ISO) E5D6T0 (/ISO) E9Q6A7 (/ISO) Q3TMJ3 (/ISO) Q6P9L3 (/ISO) Q8C473 (/ISO) Q8VDN7 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 A0A140LHY5 (/ISO) A2A654 (/ISO) A2A655 (/ISO) E5D6T0 (/ISO) E9Q6A7 (/ISO) Q3TMJ3 (/ISO) Q6P9L3 (/ISO) Q8C473 (/ISO) Q8VDN7 (/ISO)
NURF complex GO:0016589
An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters.
9 A0A140LHY5 (/ISO) A2A654 (/ISO) A2A655 (/ISO) E5D6T0 (/ISO) E9Q6A7 (/ISO) Q3TMJ3 (/ISO) Q6P9L3 (/ISO) Q8C473 (/ISO) Q8VDN7 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
9 A0A140LHY5 (/ISO) A2A654 (/ISO) A2A655 (/ISO) E5D6T0 (/ISO) E9Q6A7 (/ISO) Q3TMJ3 (/ISO) Q6P9L3 (/ISO) Q8C473 (/ISO) Q8VDN7 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
9 A0A140LHY5 (/ISO) A2A654 (/ISO) A2A655 (/ISO) E5D6T0 (/ISO) E9Q6A7 (/ISO) Q3TMJ3 (/ISO) Q6P9L3 (/ISO) Q8C473 (/ISO) Q8VDN7 (/ISO)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
9 A0A140LHY5 (/ISO) A2A654 (/ISO) A2A655 (/ISO) E5D6T0 (/ISO) E9Q6A7 (/ISO) Q3TMJ3 (/ISO) Q6P9L3 (/ISO) Q8C473 (/ISO) Q8VDN7 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
9 A0A140LHY5 (/ISO) A2A654 (/ISO) A2A655 (/ISO) E5D6T0 (/ISO) E9Q6A7 (/ISO) Q3TMJ3 (/ISO) Q6P9L3 (/ISO) Q8C473 (/ISO) Q8VDN7 (/ISO)
NURF complex GO:0016589
An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters.
3 Q12830 (/IDA) Q9W0T1 (/IDA) Q9W0T1 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q9W0T1 (/HDA) Q9W0T1 (/HDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 E7ETD6 (/IDA) Q12830 (/IDA)
NURF complex GO:0016589
An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters.
2 Q9W0T1 (/TAS) Q9W0T1 (/TAS)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 Q12830 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q12830 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q6P9L3 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q12830 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q12830 (/HDA)