The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 20: Interleukin-12 subunit alpha

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Interleukin-12 beta subunit binding GO:0042163
Interacting selectively and non-covalently with the beta subunit of interleukin-12.
8 E7ENE1 (/IPI) E9PGR3 (/IPI) O60595 (/IPI) P29459 (/IPI) P43431 (/IPI) P43431 (/IPI) Q9TU27 (/IPI) W5NVX4 (/IPI)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 E7ENE1 (/IPI) E9PGR3 (/IPI) O60595 (/IPI) P29459 (/IPI) P43431 (/IPI) P43431 (/IPI) P54349 (/IPI)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
6 E7ENE1 (/IPI) E9PGR3 (/IPI) O60595 (/IPI) P29459 (/IPI) Q9TU27 (/IPI) W5NVX4 (/IPI)
Interleukin-12 beta subunit binding GO:0042163
Interacting selectively and non-covalently with the beta subunit of interleukin-12.
2 P43431 (/ISO) P43431 (/ISO)
Interleukin-27 binding GO:0045513
Interacting selectively and non-covalently with interleukin-27.
2 P43431 (/ISO) P43431 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 P43431 (/ISO) P43431 (/ISO)
Interleukin-12 receptor binding GO:0005143
Interacting selectively and non-covalently with the interleukin-12 receptor.
1 P54349 (/IDA)
Interleukin-12 receptor binding GO:0005143
Interacting selectively and non-covalently with the interleukin-12 receptor.
1 P29459 (/NAS)
Interleukin-27 binding GO:0045513
Interacting selectively and non-covalently with interleukin-27.
1 P29459 (/IPI)

There are 61 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of mononuclear cell proliferation GO:0032946
Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation.
6 E7ENE1 (/IMP) E9PGR3 (/IMP) O60595 (/IMP) P29459 (/IMP) Q9TU27 (/IMP) W5NVX4 (/IMP)
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
3 P29459 (/IDA) P43431 (/IDA) P43431 (/IDA)
Interferon-gamma secretion GO:0072643
The regulated release of interferon-gamma from a cell.
3 P54349 (/IDA) Q9TU27 (/IDA) W5NVX4 (/IDA)
Positive regulation of T cell mediated cytotoxicity GO:0001916
Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.
2 P43431 (/ISO) P43431 (/ISO)
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002860
Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.
2 P43431 (/ISO) P43431 (/ISO)
Cell cycle arrest GO:0007050
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
2 P43431 (/ISO) P43431 (/ISO)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
2 P43431 (/IDA) P43431 (/IDA)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
2 P43431 (/IGI) P43431 (/IGI)
Response to UV-B GO:0010224
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm.
2 P43431 (/ISO) P43431 (/ISO)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
2 P43431 (/ISO) P43431 (/ISO)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
2 P43431 (/ISO) P43431 (/ISO)
Negative regulation of interleukin-17 production GO:0032700
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.
2 P43431 (/ISO) P43431 (/ISO)
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
2 P43431 (/IGI) P43431 (/IGI)
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
2 P43431 (/ISO) P43431 (/ISO)
Positive regulation of natural killer cell activation GO:0032816
Any process that activates or increases the frequency, rate or extent of natural killer cell activation.
2 P43431 (/ISO) P43431 (/ISO)
Positive regulation of mononuclear cell proliferation GO:0032946
Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation.
2 P43431 (/ISO) P43431 (/ISO)
Positive regulation of smooth muscle cell apoptotic process GO:0034393
Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process.
2 P43431 (/ISO) P43431 (/ISO)
T-helper 1 cell activation GO:0035711
The change in morphology and behavior of a T-helper 1 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
2 P43431 (/IDA) P43431 (/IDA)
T-helper 1 cell cytokine production GO:0035744
Any process that contributes to cytokine production by a T-helper 1 cell.
2 P43431 (/IGI) P43431 (/IGI)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
2 P43431 (/IDA) P43431 (/IDA)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
2 P43431 (/ISO) P43431 (/ISO)
Defense response to protozoan GO:0042832
Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism.
2 P43431 (/IDA) P43431 (/IDA)
Defense response to protozoan GO:0042832
Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism.
2 P43431 (/IGI) P43431 (/IGI)
Positive regulation of T cell differentiation GO:0045582
Any process that activates or increases the frequency, rate or extent of T cell differentiation.
2 P43431 (/IGI) P43431 (/IGI)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
2 P43431 (/ISO) P43431 (/ISO)
Positive regulation of natural killer cell mediated cytotoxicity GO:0045954
Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.
2 P43431 (/ISO) P43431 (/ISO)
Negative regulation of smooth muscle cell proliferation GO:0048662
Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.
2 P43431 (/ISO) P43431 (/ISO)
Positive regulation of lymphocyte proliferation GO:0050671
Any process that activates or increases the rate or extent of lymphocyte proliferation.
2 P43431 (/ISO) P43431 (/ISO)
Positive regulation of NK T cell activation GO:0051135
Any process that activates or increases the frequency, rate or extent of natural killer T cell activation.
2 P43431 (/ISO) P43431 (/ISO)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
2 P43431 (/IDA) P43431 (/IDA)
Extrinsic apoptotic signaling pathway GO:0097191
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
2 P43431 (/ISO) P43431 (/ISO)
Cellular response to virus GO:0098586
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
2 P43431 (/ISO) P43431 (/ISO)
Positive regulation of dendritic cell chemotaxis GO:2000510
Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis.
2 P43431 (/ISO) P43431 (/ISO)
Positive regulation of T cell mediated cytotoxicity GO:0001916
Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.
1 P29459 (/IDA)
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002860
Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.
1 P29459 (/IDA)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
1 P29459 (/TAS)
Cell cycle arrest GO:0007050
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
1 P29459 (/IDA)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
1 P29459 (/IEP)
Response to UV-B GO:0010224
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm.
1 P29459 (/IDA)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 P29459 (/IDA)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P29459 (/TAS)
Natural killer cell activation GO:0030101
The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.
1 P54349 (/ISS)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P29459 (/IDA)
Negative regulation of interleukin-17 production GO:0032700
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.
1 P29459 (/IDA)
Positive regulation of natural killer cell activation GO:0032816
Any process that activates or increases the frequency, rate or extent of natural killer cell activation.
1 P29459 (/IDA)
Positive regulation of smooth muscle cell apoptotic process GO:0034393
Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process.
1 P29459 (/IDA)
Interleukin-12-mediated signaling pathway GO:0035722
A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P29459 (/TAS)
T-helper cell differentiation GO:0042093
The process in which a relatively unspecialized thymocyte acquires specialized features of a T-helper cell.
1 P54349 (/ISS)
Interferon-gamma biosynthetic process GO:0042095
The chemical reactions and pathways resulting in the formation of interferon-gamma. Interferon gamma is the only member of the type II interferon found so far.
1 P54349 (/IDA)
Positive regulation of activated T cell proliferation GO:0042104
Any process that activates or increases the rate or extent of activated T cell proliferation.
1 P54349 (/IDA)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
1 P29459 (/IDA)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
1 P29459 (/IDA)
Positive regulation of natural killer cell mediated cytotoxicity GO:0045954
Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.
1 P29459 (/IDA)
Negative regulation of smooth muscle cell proliferation GO:0048662
Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.
1 P29459 (/IDA)
Positive regulation of lymphocyte proliferation GO:0050671
Any process that activates or increases the rate or extent of lymphocyte proliferation.
1 P29459 (/IDA)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
1 P29459 (/IEP)
Positive regulation of NK T cell activation GO:0051135
Any process that activates or increases the frequency, rate or extent of natural killer T cell activation.
1 P29459 (/IDA)
Interleukin-35-mediated signaling pathway GO:0070757
A series of molecular signals initiated by the binding of interleukin-35 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P29459 (/TAS)
Extrinsic apoptotic signaling pathway GO:0097191
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
1 P29459 (/IDA)
Cellular response to virus GO:0098586
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
1 P29459 (/IMP)
Positive regulation of dendritic cell chemotaxis GO:2000510
Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis.
1 P29459 (/IMP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Interleukin-12 complex GO:0043514
A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space.
8 E7ENE1 (/IDA) E9PGR3 (/IDA) O60595 (/IDA) P29459 (/IDA) P43431 (/IDA) P43431 (/IDA) Q9TU27 (/IDA) W5NVX4 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
6 P29459 (/IDA) P43431 (/IDA) P43431 (/IDA) P54349 (/IDA) Q9TU27 (/IDA) W5NVX4 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 P29459 (/TAS) P43431 (/TAS) P43431 (/TAS)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
3 P29459 (/TAS) P43431 (/TAS) P43431 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P43431 (/ISO) P43431 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P43431 (/IDA) P43431 (/IDA)
Golgi lumen GO:0005796
The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks.
2 P43431 (/TAS) P43431 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 P43431 (/IDA) P43431 (/IDA)
Endosome lumen GO:0031904
The volume enclosed by the membrane of an endosome.
2 P43431 (/TAS) P43431 (/TAS)
Interleukin-12 complex GO:0043514
A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space.
2 P43431 (/IGI) P43431 (/IGI)
Interleukin-12 complex GO:0043514
A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space.
2 P43431 (/ISO) P43431 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P54349 (/NAS)
Late endosome lumen GO:0031906
The volume enclosed by the membrane of a late endosome.
1 P29459 (/TAS)
Interleukin-12 complex GO:0043514
A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space.
1 P29459 (/NAS)