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CATH Superfamily 1.20.1250.10

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17: Interleukin 11

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
 6 P20808 (/ISS) P20808 (/ISS) P20808 (/ISS) P20808 (/ISS) P47873 (/ISS) P47873 (/ISS)
Interleukin-11 receptor binding GO:0005142
Interacting selectively and non-covalently with the interleukin-11 receptor.
 5 P20809 (/NAS) P20809 (/NAS) P20809 (/NAS) P20809 (/NAS) P20809 (/NAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 5 P20809 (/IPI) P20809 (/IPI) P20809 (/IPI) P20809 (/IPI) P20809 (/IPI)
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
 5 P20809 (/IDA) P20809 (/IDA) P20809 (/IDA) P20809 (/IDA) P20809 (/IDA)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
 2 P47873 (/IDA) P47873 (/IDA)
Interleukin-11 receptor binding GO:0005142
Interacting selectively and non-covalently with the interleukin-11 receptor.
 2 P47873 (/IPI) P47873 (/IPI)
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
 2 P47873 (/ISO) P47873 (/ISO)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
 7 P20809 (/IDA) P20809 (/IDA) P20809 (/IDA) P20809 (/IDA) P20809 (/IDA) P47873 (/IDA) P47873 (/IDA)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
 5 P20809 (/TAS) P20809 (/TAS) P20809 (/TAS) P20809 (/TAS) P20809 (/TAS)
B cell differentiation GO:0030183
The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
 5 P20809 (/NAS) P20809 (/NAS) P20809 (/NAS) P20809 (/NAS) P20809 (/NAS)
Megakaryocyte differentiation GO:0030219
The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.
 5 P20809 (/NAS) P20809 (/NAS) P20809 (/NAS) P20809 (/NAS) P20809 (/NAS)
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
 5 P20809 (/IDA) P20809 (/IDA) P20809 (/IDA) P20809 (/IDA) P20809 (/IDA)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
 5 P20809 (/IDA) P20809 (/IDA) P20809 (/IDA) P20809 (/IDA) P20809 (/IDA)
Fat cell differentiation GO:0045444
The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
 5 P20809 (/NAS) P20809 (/NAS) P20809 (/NAS) P20809 (/NAS) P20809 (/NAS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
 5 P20809 (/IDA) P20809 (/IDA) P20809 (/IDA) P20809 (/IDA) P20809 (/IDA)
Negative regulation of hormone secretion GO:0046888
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.
 5 P20809 (/IDA) P20809 (/IDA) P20809 (/IDA) P20809 (/IDA) P20809 (/IDA)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
 5 P20809 (/IDA) P20809 (/IDA) P20809 (/IDA) P20809 (/IDA) P20809 (/IDA)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
 2 P47873 (/ISO) P47873 (/ISO)
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
 2 P47873 (/ISO) P47873 (/ISO)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
 2 P47873 (/ISO) P47873 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
 2 P47873 (/ISO) P47873 (/ISO)
Negative regulation of hormone secretion GO:0046888
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.
 2 P47873 (/ISO) P47873 (/ISO)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
 2 P47873 (/ISO) P47873 (/ISO)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
 5 P20809 (/TAS) P20809 (/TAS) P20809 (/TAS) P20809 (/TAS) P20809 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 2 P47873 (/IDA) P47873 (/IDA)