The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleotidyltransferases domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 2: ARF GTPase-activating protein GIT2 isoform 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 Q14161 (/IPI) Q68FF6 (/IPI) Q9JLQ2 (/IPI) Q9Y2X7 (/IPI) Q9Z272 (/IPI)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
2 Q68FF6 (/IPI) Q9JLQ2 (/IPI)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 Q9Z272 (/IDA)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 Q68FF6 (/ISO)
Small GTPase binding GO:0031267
Interacting selectively and non-covalently with a small monomeric GTPase.
1 Q9Z272 (/IDA)
Small GTPase binding GO:0031267
Interacting selectively and non-covalently with a small monomeric GTPase.
1 Q68FF6 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9Z272 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q68FF6 (/ISO)
Structural constituent of postsynaptic specialization GO:0098879
The action of a molecule that contributes to the structural integrity of a postsynaptic specialization.
1 Q9Z272 (/IDA)
Structural constituent of postsynaptic specialization GO:0098879
The action of a molecule that contributes to the structural integrity of a postsynaptic specialization.
1 Q9Z272 (/IMP)
Structural constituent of postsynaptic specialization GO:0098879
The action of a molecule that contributes to the structural integrity of a postsynaptic specialization.
1 Q68FF6 (/ISO)

There are 28 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
2 A0A0R4IPR8 (/IMP) E7FAZ2 (/IMP)
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
2 A0A0R4IPR8 (/IMP) E7FAZ2 (/IMP)
Regulation of G protein-coupled receptor signaling pathway GO:0008277
Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.
2 Q14161 (/TAS) Q9Y2X7 (/TAS)
Presynaptic modulation of chemical synaptic transmission GO:0099171
Any process, acting in the presynapse that results in modulation of chemical synaptic transmission.
2 Q68FF6 (/IMP) Q9JLQ2 (/IMP)
Regulation of synaptic vesicle exocytosis GO:2000300
Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
2 Q68FF6 (/IMP) Q9JLQ2 (/IMP)
Immunological synapse formation GO:0001771
The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
1 Q9Z272 (/IGI)
Immunological synapse formation GO:0001771
The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
1 Q68FF6 (/ISO)
Regulation of G protein-coupled receptor signaling pathway GO:0008277
Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.
1 Q9Z272 (/IDA)
Regulation of G protein-coupled receptor signaling pathway GO:0008277
Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.
1 Q68FF6 (/ISO)
Regulation of cell morphogenesis GO:0022604
Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.
1 A2BG45 (/IMP)
Negative regulation of ARF protein signal transduction GO:0032013
Any process that stops, prevents, or reduces the frequency, rate or extent of ARF protein signal transduction.
1 Q9Z272 (/IDA)
Negative regulation of ARF protein signal transduction GO:0032013
Any process that stops, prevents, or reduces the frequency, rate or extent of ARF protein signal transduction.
1 Q68FF6 (/ISO)
Regulation of cytokinesis GO:0032465
Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
1 Q9Y2X7 (/IDA)
Regulation of cytokinesis GO:0032465
Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
1 Q68FF6 (/ISO)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
1 Q9DG15 (/IMP)
Cell migration involved in gastrulation GO:0042074
The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).
1 A2BG45 (/IMP)
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
1 Q68FF6 (/IDA)
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
1 Q9Y2X7 (/TAS)
Behavioral response to pain GO:0048266
Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.
1 Q9JLQ2 (/IMP)
Dendritic spine development GO:0060996
The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
1 Q9Z272 (/IGI)
Dendritic spine development GO:0060996
The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
1 Q68FF6 (/ISO)
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
1 Q9Z272 (/IDA)
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
1 Q68FF6 (/ISO)
Neurotransmitter receptor localization to postsynaptic specialization membrane GO:0099645
A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density).
1 Q9Z272 (/IDA)
Neurotransmitter receptor localization to postsynaptic specialization membrane GO:0099645
A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density).
1 Q9Z272 (/IMP)
Neurotransmitter receptor localization to postsynaptic specialization membrane GO:0099645
A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density).
1 Q68FF6 (/ISO)
Positive regulation of receptor catabolic process GO:2000646
Any process that activates or increases the frequency, rate or extent of receptor catabolic process.
1 Q9Z272 (/IMP)
Positive regulation of receptor catabolic process GO:2000646
Any process that activates or increases the frequency, rate or extent of receptor catabolic process.
1 Q68FF6 (/ISO)

There are 27 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 A0A0C4DGN6 (/IDA) Q9Y2X7 (/IDA) Q9Z272 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q68FF6 (/TAS) Q9Y2X7 (/TAS) Q9Z272 (/TAS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
2 Q14161 (/HDA) Q9Y2X7 (/HDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
2 A0A0C4DGN6 (/IDA) Q9Y2X7 (/IDA)
Calyx of Held GO:0044305
The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system.
2 Q68FF6 (/IMP) Q9JLQ2 (/IMP)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q14161 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9JLQ2 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9DG15 (/IDA)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 Q9Z272 (/IDA)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 Q68FF6 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q68FF6 (/ISO)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 Q68FF6 (/ISO)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 Q9Z272 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9Y2X7 (/HDA)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
1 Q9DG15 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q9DE64 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q9Z272 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q68FF6 (/ISO)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 Q9Z272 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 Q68FF6 (/ISO)
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
1 Q9Z272 (/IDA)
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
1 Q68FF6 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q9Z272 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q68FF6 (/ISO)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
1 Q9Z272 (/IDA)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
1 Q9Z272 (/IMP)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
1 Q68FF6 (/ISO)