The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Calcium-transporting ATPase, transmembrane domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15: Sodium ion P-type ATPase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Potassium:proton exchanging ATPase activity GO:0008900
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in).
3 C8VNH3 (/RCA) Q5AYI8 (/RCA) Q5AYI8 (/RCA)
Sodium transmembrane transporter activity, phosphorylative mechanism GO:0008554
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out); by a phosphorylative mechanism.
2 P13587 (/IGI) Q01896 (/IGI)
Potassium transmembrane transporter activity, phosphorylative mechanism GO:0008556
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in).
2 P13587 (/IMP) Q01896 (/IMP)
Ion transmembrane transporter activity, phosphorylative mechanism GO:0015662
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate.
2 Q01896 (/ISS) Q12691 (/ISS)
Calcium transmembrane transporter activity, phosphorylative mechanism GO:0005388
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans).
1 P22189 (/IMP)
Proton-exporting ATPase activity, phosphorylative mechanism GO:0008553
Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle.
1 C8VNH3 (/RCA)
Sodium transmembrane transporter activity, phosphorylative mechanism GO:0008554
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out); by a phosphorylative mechanism.
1 P13587 (/IDA)
Sodium transmembrane transporter activity, phosphorylative mechanism GO:0008554
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out); by a phosphorylative mechanism.
1 Q01896 (/ISS)
Potassium transmembrane transporter activity, phosphorylative mechanism GO:0008556
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in).
1 P22189 (/IDA)
Ion transmembrane transporter activity, phosphorylative mechanism GO:0015662
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate.
1 Q01896 (/IGI)
Cation efflux transmembrane transporter activity GO:0046583
Enables the transfer of a cation or cations from the inside of the cell to the outside of the cell across a membrane.
1 Q6FM06 (/IDA)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Generation of precursor metabolites and energy GO:0006091
The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
3 C8VNH3 (/RCA) Q5AYI8 (/RCA) Q5AYI8 (/RCA)
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 P13587 (/IGI) Q01896 (/IGI) Q6FM06 (/IGI)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P13587 (/IMP) Q01896 (/IMP)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
2 P13587 (/IMP) Q01896 (/IMP)
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q6FM06 (/IDA)
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q12691 (/ISS)
Cellular sodium ion homeostasis GO:0006883
Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
1 Q6FM06 (/IDA)
Hyperosmotic response GO:0006972
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
1 P13587 (/IGI)
Response to pH GO:0009268
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
1 P13587 (/IGI)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 P13587 (/IDA)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 P13587 (/IGI)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 P13587 (/IMP)
Cellular response to glucose starvation GO:0042149
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
1 P13587 (/IMP)
Sequestering of calcium ion GO:0051208
The process of binding or confining calcium ions such that they are separated from other components of a biological system.
1 P22189 (/IDA)
Sodium ion homeostasis GO:0055078
Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell.
1 Q6FM06 (/IMP)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
1 P13587 (/IDA)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
1 Q12691 (/ISS)
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 P22189 (/IMP)
Potassium ion export across plasma membrane GO:0097623
The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region.
1 P22189 (/IDA)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P13587 (/IDA) P22189 (/IDA) Q01896 (/IDA) Q6FM06 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P13587 (/HDA) Q12691 (/HDA)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
2 P13587 (/HDA) Q12691 (/HDA)
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
1 P13587 (/HDA)
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
1 P22189 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q01896 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q12691 (/ISS)