The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Dehydroquinate synthase-like - alpha domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Aldehyde-alcohol dehydrogenase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 24 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Alcohol dehydrogenase (NAD) activity GO:0004022
Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.
160 P0A9Q7 (/IMP) P0A9Q7 (/IMP) P0A9Q7 (/IMP) P0A9Q7 (/IMP) P0A9Q7 (/IMP) P0A9Q7 (/IMP) P0A9Q7 (/IMP) P0A9Q7 (/IMP) P0A9Q7 (/IMP) P0A9Q7 (/IMP)
(150 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
125 A0A0H2USH2 (/IPI) A0A0H2USH2 (/IPI) A0A0H2USH2 (/IPI) P0A9Q7 (/IPI) P0A9Q7 (/IPI) P0A9Q7 (/IPI) P0A9Q7 (/IPI) P0A9Q7 (/IPI) P0A9Q7 (/IPI) P0A9Q7 (/IPI)
(115 more)
Acetaldehyde dehydrogenase (acetylating) activity GO:0008774
Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+.
122 P0A9Q7 (/IMP) P0A9Q7 (/IMP) P0A9Q7 (/IMP) P0A9Q7 (/IMP) P0A9Q7 (/IMP) P0A9Q7 (/IMP) P0A9Q7 (/IMP) P0A9Q7 (/IMP) P0A9Q7 (/IMP) P0A9Q7 (/IMP)
(112 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
122 P0A9Q7 (/IPI) P0A9Q7 (/IPI) P0A9Q7 (/IPI) P0A9Q7 (/IPI) P0A9Q7 (/IPI) P0A9Q7 (/IPI) P0A9Q7 (/IPI) P0A9Q7 (/IPI) P0A9Q7 (/IPI) P0A9Q7 (/IPI)
(112 more)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
62 P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA)
(52 more)
Lactaldehyde reductase activity GO:0008912
Catalysis of the reaction: propane-1,2-diol + NAD+ = lactaldehyde + NADH + H+.
62 P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA)
(52 more)
L-threonine 3-dehydrogenase activity GO:0008743
Catalysis of the reaction: L-threonine + NAD(+) = aminoacetone + CO(2) + NADH.
16 P37686 (/IDA) P37686 (/IDA) P37686 (/IDA) P37686 (/IDA) P37686 (/IDA) P37686 (/IDA) P37686 (/IDA) P37686 (/IDA) P37686 (/IDA) P37686 (/IDA)
(6 more)
Alcohol dehydrogenase (NAD) activity GO:0004022
Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.
13 P10127 (/IDA) P33744 (/IDA) P33744 (/IDA) P33744 (/IDA) Q24803 (/IDA) Q6Q3H8 (/IDA) Q6Q3I0 (/IDA) Q6Q3I1 (/IDA) Q6Q3I2 (/IDA) Q9ANR5 (/IDA)
(3 more)
Alcohol dehydrogenase activity, iron-dependent GO:0004025
Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron.
12 A0A0F7RD65 (/ISS) A0A0F7RD65 (/ISS) Q881D7 (/ISS) Q881D7 (/ISS) Q8EGV1 (/ISS) Q9KQG5 (/ISS) Q9KQG5 (/ISS) Q9KQG5 (/ISS) Q9KQG5 (/ISS) Q9KQG5 (/ISS)
(2 more)
3-chloroallyl aldehyde dehydrogenase activity GO:0004028
Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.
9 A0A0F7RD65 (/ISS) A0A0F7RD65 (/ISS) Q9KQG5 (/ISS) Q9KQG5 (/ISS) Q9KQG5 (/ISS) Q9KQG5 (/ISS) Q9KQG5 (/ISS) Q9KQG5 (/ISS) Q9KQG5 (/ISS)
Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616
Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
9 P76553 (/IDA) P76553 (/IDA) P76553 (/IDA) P76553 (/IDA) P76553 (/IDA) P76553 (/IDA) P76553 (/IDA) P76553 (/IDA) P76553 (/IDA)
1,3-propanediol dehydrogenase activity GO:0047516
Catalysis of the reaction: propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+.
5 P45513 (/IDA) P45513 (/IDA) P45513 (/IDA) P45513 (/IDA) P45513 (/IDA)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
4 Q9ANR5 (/IDA) Q9ANR5 (/IDA) Q9ANR5 (/IDA) Q9ANR5 (/IDA)
Heat shock protein binding GO:0031072
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
4 Q6Q3H8 (/IPI) Q6Q3I0 (/IPI) Q6Q3I1 (/IPI) Q6Q3I2 (/IPI)
Acetaldehyde dehydrogenase (acetylating) activity GO:0008774
Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+.
2 Q24803 (/IDA) Q6Q3I2 (/IDA)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 P31005 (/IDA)
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
1 Q24803 (/IDA)
Alcohol dehydrogenase activity, zinc-dependent GO:0004024
Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc.
1 Q09669 (/ISO)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
1 Q8EGV1 (/ISS)
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
1 Q24803 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 P31005 (/IDA)
Acetaldehyde dehydrogenase (acetylating) activity GO:0008774
Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+.
1 Q24803 (/TAS)
Laminin binding GO:0043236
Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.
1 Q24803 (/IDA)
Methanol dehydrogenase activity GO:0050093
Catalysis of the reaction: methanol + NAD(+) = formaldehyde + H(+) + NADH.
1 P31005 (/IDA)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ethanol biosynthetic process GO:0006115
The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.
122 P0A9Q7 (/IDA) P0A9Q7 (/IDA) P0A9Q7 (/IDA) P0A9Q7 (/IDA) P0A9Q7 (/IDA) P0A9Q7 (/IDA) P0A9Q7 (/IDA) P0A9Q7 (/IDA) P0A9Q7 (/IDA) P0A9Q7 (/IDA)
(112 more)
Rhamnose catabolic process GO:0019301
The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose.
62 P0A9S1 (/IEP) P0A9S1 (/IEP) P0A9S1 (/IEP) P0A9S1 (/IEP) P0A9S1 (/IEP) P0A9S1 (/IEP) P0A9S1 (/IEP) P0A9S1 (/IEP) P0A9S1 (/IEP) P0A9S1 (/IEP)
(52 more)
L-fucose catabolic process GO:0042355
The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose).
62 P0A9S1 (/IMP) P0A9S1 (/IMP) P0A9S1 (/IMP) P0A9S1 (/IMP) P0A9S1 (/IMP) P0A9S1 (/IMP) P0A9S1 (/IMP) P0A9S1 (/IMP) P0A9S1 (/IMP) P0A9S1 (/IMP)
(52 more)
Glycol catabolic process GO:0042846
The chemical reactions and pathways resulting in the breakdown of glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent.
62 P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA)
(52 more)
Propanediol metabolic process GO:0051143
The chemical reactions and pathways involving propanediol, CH3-CHOH-CH2OH, a sweet, colorless, viscous, hygroscopic liquid used as an antifreeze, in brake fluid and as a humectant in cosmetics and personal care items.
62 P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA) P0A9S1 (/IDA)
(52 more)
Fermentation GO:0006113
The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, coupling the oxidation and reduction of NAD/H and the generation of adenosine triphosphate (ATP).
12 A0A0F7RD65 (/ISS) A0A0F7RD65 (/ISS) Q881D7 (/ISS) Q881D7 (/ISS) Q8EGV1 (/ISS) Q9KQG5 (/ISS) Q9KQG5 (/ISS) Q9KQG5 (/ISS) Q9KQG5 (/ISS) Q9KQG5 (/ISS)
(2 more)
Alcohol catabolic process GO:0046164
The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
4 Q6Q3H8 (/IDA) Q6Q3I0 (/IDA) Q6Q3I1 (/IDA) Q6Q3I2 (/IDA)
Acetaldehyde catabolic process GO:0046187
The chemical reactions and pathways resulting in the breakdown of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol.
4 Q6Q3H8 (/IDA) Q6Q3I0 (/IDA) Q6Q3I1 (/IDA) Q6Q3I2 (/IDA)
1-butanol biosynthetic process GO:0071271
The chemical reactions and pathways resulting in the formation of 1-butanol, an alkyl primary alcohol with the formula C4H10O.
4 Q9ANR5 (/IDA) Q9ANR5 (/IDA) Q9ANR5 (/IDA) Q9ANR5 (/IDA)
Amino acid catabolic process to alcohol via Ehrlich pathway GO:0000947
The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.
1 P10127 (/IGI)
Fermentation GO:0006113
The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, coupling the oxidation and reduction of NAD/H and the generation of adenosine triphosphate (ATP).
1 P10127 (/IMP)
Ethanol biosynthetic process involved in glucose fermentation to ethanol GO:0043458
The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, as part of the process of glucose catabolism to ethanol, CO2 and ATP.
1 Q09669 (/IGI)
Adhesion of symbiont to host epithelial cell GO:0044651
The attachment of a symbiont to a host epithelial cell via adhesion molecules, general stickiness etc., either directly or indirectly.
1 Q6Q3I2 (/IMP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
184 P0A9Q7 (/IDA) P0A9Q7 (/IDA) P0A9Q7 (/IDA) P0A9Q7 (/IDA) P0A9Q7 (/IDA) P0A9Q7 (/IDA) P0A9Q7 (/IDA) P0A9Q7 (/IDA) P0A9Q7 (/IDA) P0A9Q7 (/IDA)
(174 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
122 P0A9Q7 (/HDA) P0A9Q7 (/HDA) P0A9Q7 (/HDA) P0A9Q7 (/HDA) P0A9Q7 (/HDA) P0A9Q7 (/HDA) P0A9Q7 (/HDA) P0A9Q7 (/HDA) P0A9Q7 (/HDA) P0A9Q7 (/HDA)
(112 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
122 P0A9Q7 (/HDA) P0A9Q7 (/HDA) P0A9Q7 (/HDA) P0A9Q7 (/HDA) P0A9Q7 (/HDA) P0A9Q7 (/HDA) P0A9Q7 (/HDA) P0A9Q7 (/HDA) P0A9Q7 (/HDA) P0A9Q7 (/HDA)
(112 more)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
3 Q6Q3I0 (/IDA) Q6Q3I1 (/IDA) Q6Q3I2 (/IDA)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
2 Q6Q3I1 (/IDA) Q6Q3I2 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P10127 (/HDA) Q09669 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q6Q3I2 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P31005 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P10127 (/IDA)