The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 26: C-C chemokine receptor type 5
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 41 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
C-C chemokine receptor activity GO:0016493
Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.
|
109 |
O08556 (/ISS)
O62743 (/ISS)
O62743 (/ISS)
O62743 (/ISS)
O97878 (/ISS)
O97879 (/ISS)
O97879 (/ISS)
O97879 (/ISS)
O97880 (/ISS)
O97881 (/ISS)
(99 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
21 |
O08556 (/IPI)
P32246 (/IPI)
P32246 (/IPI)
P41597 (/IPI)
P49238 (/IPI)
P51675 (/IPI)
P51677 (/IPI)
P51677 (/IPI)
P51678 (/IPI)
P51679 (/IPI)
(11 more) |
|
Chemokine receptor activity GO:0004950
Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
|
16 |
O54814 (/TAS)
P32246 (/TAS)
P32246 (/TAS)
P41597 (/TAS)
P49238 (/TAS)
P51677 (/TAS)
P51677 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
(6 more) |
|
C-C chemokine receptor activity GO:0016493
Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.
|
11 |
P32246 (/IDA)
P32246 (/IDA)
P51675 (/IDA)
P51678 (/IDA)
P51681 (/IDA)
P51681 (/IDA)
P51682 (/IDA)
P51683 (/IDA)
P51683 (/IDA)
P56484 (/IDA)
(1 more) |
|
C-C chemokine binding GO:0019957
Interacting selectively and non-covalently with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.
|
6 | P32246 (/IPI) P32246 (/IPI) P51678 (/IPI) P51681 (/IPI) P51681 (/IPI) P51682 (/IPI) |
|
C-X3-C chemokine binding GO:0019960
Interacting selectively and non-covalently with a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif.
|
4 | A6QNL7 (/ISS) P35411 (/ISS) P49238 (/ISS) Q2KTE1 (/ISS) |
|
Chemokine (C-C motif) ligand 7 binding GO:0035717
Interacting selectively and non-covalently with chemokine (C-C motif) ligand 7.
|
4 | P32246 (/IPI) P32246 (/IPI) P51683 (/IPI) P51683 (/IPI) |
|
Chemokine (C-C motif) ligand 5 binding GO:0071791
Interacting selectively and non-covalently with chemokine (C-C motif) ligand 5.
|
4 | P32246 (/IPI) P32246 (/IPI) P51681 (/IPI) P51681 (/IPI) |
|
Coreceptor activity GO:0015026
Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.
|
3 | P51681 (/TAS) P51681 (/TAS) P51685 (/TAS) |
|
C-C chemokine receptor activity GO:0016493
Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.
|
3 | G3V7C3 (/TAS) O08556 (/TAS) Q91ZH4 (/TAS) |
|
C-C chemokine binding GO:0019957
Interacting selectively and non-covalently with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.
|
3 | P51677 (/IDA) P51677 (/IDA) Q9JLY8 (/IDA) |
|
C-C chemokine binding GO:0019957
Interacting selectively and non-covalently with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.
|
3 | P51675 (/ISO) P51678 (/ISO) P51682 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
3 | P41597 (/ISS) P51683 (/ISS) P51683 (/ISS) |
|
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
2 | P51681 (/IDA) P51681 (/IDA) |
|
Phosphatidylinositol phospholipase C activity GO:0004435
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
|
2 | P32246 (/IDA) P32246 (/IDA) |
|
Phosphatidylinositol phospholipase C activity GO:0004435
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
|
2 | P51681 (/TAS) P51681 (/TAS) |
|
Cytokine receptor activity GO:0004896
Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
2 | Q9Z0D9 (/IMP) Q9Z0D9 (/IMP) |
|
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
2 | Q9Z0D9 (/IMP) Q9Z0D9 (/IMP) |
|
Chemokine receptor activity GO:0004950
Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
|
2 | P32246 (/IDA) P32246 (/IDA) |
|
C-C chemokine receptor activity GO:0016493
Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.
|
2 | P51675 (/ISO) P51682 (/ISO) |
|
C-C chemokine receptor activity GO:0016493
Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.
|
2 | P51681 (/NAS) P51681 (/NAS) |
|
C-X3-C chemokine receptor activity GO:0016495
Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif.
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Cytokine binding GO:0019955
Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
|
2 | P51683 (/IPI) P51683 (/IPI) |
|
C-X3-C chemokine binding GO:0019960
Interacting selectively and non-covalently with a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif.
|
2 | Q9Z0D9 (/IPI) Q9Z0D9 (/IPI) |
|
C-X3-C chemokine binding GO:0019960
Interacting selectively and non-covalently with a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif.
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Chemokine (C-C motif) ligand 2 binding GO:0035715
Interacting selectively and non-covalently with chemokine (C-C motif) ligand 2.
|
2 | P51683 (/IPI) P51683 (/IPI) |
|
Chemokine (C-C motif) ligand 12 binding GO:0035716
Interacting selectively and non-covalently with chemokine (C-C motif) ligand 12.
|
2 | P51683 (/IPI) P51683 (/IPI) |
|
Chemokine (C-C motif) ligand 5 binding GO:0071791
Interacting selectively and non-covalently with chemokine (C-C motif) ligand 5.
|
2 | P51675 (/ISO) P51682 (/ISO) |
|
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
1 | P51682 (/ISO) |
|
Phosphatidylinositol phospholipase C activity GO:0004435
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
|
1 | P51675 (/ISO) |
|
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
1 | P49238 (/ISS) |
|
Chemokine receptor activity GO:0004950
Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
|
1 | P51675 (/ISO) |
|
G protein-coupled peptide receptor activity GO:0008528
Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
1 | P49238 (/TAS) |
|
C-C chemokine receptor activity GO:0016493
Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.
|
1 | P51680 (/IMP) |
|
C-X3-C chemokine receptor activity GO:0016495
Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif.
|
1 | P35411 (/IDA) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | O08556 (/IPI) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | P51682 (/ISO) |
|
C-X3-C chemokine binding GO:0019960
Interacting selectively and non-covalently with a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif.
|
1 | P49238 (/IDA) |
|
CCR2 chemokine receptor binding GO:0031727
Interacting selectively and non-covalently with a CCR2 chemokine receptor.
|
1 | P41597 (/IDA) |
|
Chemokine (C-C motif) ligand 7 binding GO:0035717
Interacting selectively and non-covalently with chemokine (C-C motif) ligand 7.
|
1 | P51675 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | O55193 (/IDA) |
There are 279 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
15 |
P32246 (/TAS)
P32246 (/TAS)
P41597 (/TAS)
P49238 (/TAS)
P51677 (/TAS)
P51677 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
(5 more) |
|
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
13 |
P41597 (/TAS)
P49238 (/TAS)
P51677 (/TAS)
P51677 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
(3 more) |
|
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
13 |
P32246 (/TAS)
P32246 (/TAS)
P41597 (/TAS)
P51677 (/TAS)
P51677 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
(3 more) |
|
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
12 |
P41597 (/TAS)
P51677 (/TAS)
P51677 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
P51681 (/TAS)
(2 more) |
|
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
|
10 | P41597 (/TAS) P51679 (/TAS) P51679 (/TAS) P51679 (/TAS) P51679 (/TAS) P51679 (/TAS) P51679 (/TAS) P51681 (/TAS) P51681 (/TAS) P51685 (/TAS) |
|
Positive regulation of monocyte chemotaxis GO:0090026
Any process that increases the frequency, rate, or extent of monocyte chemotaxis.
|
8 | O18793 (/ISS) O55193 (/ISS) P41597 (/ISS) P51675 (/ISS) P56482 (/ISS) Q2Y2P0 (/ISS) Q2Y2P0 (/ISS) Q2Y2P0 (/ISS) |
|
Cellular defense response GO:0006968
A defense response that is mediated by cells.
|
6 | P41597 (/TAS) P49238 (/TAS) P51677 (/TAS) P51677 (/TAS) P51681 (/TAS) P51681 (/TAS) |
|
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
6 | P32246 (/TAS) P32246 (/TAS) P49238 (/TAS) P51677 (/TAS) P51677 (/TAS) P51685 (/TAS) |
|
Dendritic cell chemotaxis GO:0002407
The movement of a dendritic cell in response to an external stimulus.
|
5 | P32246 (/TAS) P32246 (/TAS) P41597 (/TAS) P51681 (/TAS) P51681 (/TAS) |
|
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
5 | P32246 (/TAS) P32246 (/TAS) P41597 (/TAS) P51681 (/TAS) P51681 (/TAS) |
|
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
4 | P32246 (/IDA) P32246 (/IDA) P51681 (/IDA) P51681 (/IDA) |
|
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
4 | P51675 (/IMP) P51680 (/IMP) P51683 (/IMP) P51683 (/IMP) |
|
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
4 | P32246 (/TAS) P32246 (/TAS) P51681 (/TAS) P51681 (/TAS) |
|
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
|
4 | P32246 (/IDA) P32246 (/IDA) P51681 (/IDA) P51681 (/IDA) |
|
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
|
4 | P32246 (/TAS) P32246 (/TAS) P41597 (/TAS) P49238 (/TAS) |
|
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
|
4 | P51683 (/IMP) P51683 (/IMP) Q9Z0D9 (/IMP) Q9Z0D9 (/IMP) |
|
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
|
4 | P35411 (/IMP) P51677 (/IMP) P51677 (/IMP) P51678 (/IMP) |
|
Blood vessel remodeling GO:0001974
The reorganization or renovation of existing blood vessels.
|
3 | P41597 (/ISS) P51683 (/ISS) P51683 (/ISS) |
|
Regulation of T cell cytokine production GO:0002724
Any process that modulates the frequency, rate, or extent of T cell cytokine production.
|
3 | O18793 (/ISS) O55193 (/ISS) P41597 (/ISS) |
|
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
|
3 | O55193 (/IDA) P32246 (/IDA) P32246 (/IDA) |
|
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
|
3 | P41597 (/ISS) P51683 (/ISS) P51683 (/ISS) |
|
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
3 | P51678 (/IDA) P56484 (/IDA) P56484 (/IDA) |
|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
3 | O55193 (/IMP) P51681 (/IMP) P51681 (/IMP) |
|
Sensory perception of pain GO:0019233
The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
|
3 | O18793 (/ISS) O55193 (/ISS) P41597 (/ISS) |
|
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
|
3 | P51682 (/ISO) Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Monocyte extravasation GO:0035696
The migration of a monocyte from the blood vessels into the surrounding tissue.
|
3 | O18793 (/ISS) O55193 (/ISS) P41597 (/ISS) |
|
Monocyte activation GO:0042117
The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
|
3 | A0A140LFN4 (/IMP) A0A140LFQ7 (/IMP) F1QYD4 (/IMP) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
3 | P49238 (/IC) Q9Z0D9 (/IC) Q9Z0D9 (/IC) |
|
Regulation of T cell differentiation GO:0045580
Any process that modulates the frequency, rate or extent of T cell differentiation.
|
3 | O18793 (/ISS) O55193 (/ISS) P41597 (/ISS) |
|
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
|
3 | P51678 (/ISO) Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
|
3 | O18793 (/ISS) O55193 (/ISS) P41597 (/ISS) |
|
Positive regulation of synaptic transmission, glutamatergic GO:0051968
Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
|
3 | O18793 (/ISS) O55193 (/ISS) P41597 (/ISS) |
|
Chemokine-mediated signaling pathway GO:0070098
A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | P41597 (/ISS) P51683 (/ISS) P51683 (/ISS) |
|
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
3 | P35411 (/IEP) P51681 (/IEP) P51681 (/IEP) |
|
Positive regulation of monocyte chemotaxis GO:0090026
Any process that increases the frequency, rate, or extent of monocyte chemotaxis.
|
3 | P32246 (/IDA) P32246 (/IDA) P41597 (/IDA) |
|
Positive regulation of monocyte chemotaxis GO:0090026
Any process that increases the frequency, rate, or extent of monocyte chemotaxis.
|
3 | P51675 (/ISO) P51683 (/ISO) P51683 (/ISO) |
|
Inflammatory response to wounding GO:0090594
The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents.
|
3 | O18793 (/ISS) O55193 (/ISS) P41597 (/ISS) |
|
Macrophage migration GO:1905517
The orderly movement of a macrophage from one site to another.
|
3 | O18793 (/ISS) O55193 (/ISS) P41597 (/ISS) |
|
Positive regulation of thymocyte migration GO:2000412
Any process that activates or increases the frequency, rate or extent of thymocyte migration.
|
3 | O18793 (/ISS) O55193 (/ISS) P41597 (/ISS) |
|
Positive regulation of astrocyte chemotaxis GO:2000464
Any process that activates or increases the frequency, rate or extent of astrocyte chemotaxis.
|
3 | O55193 (/ISS) P51683 (/ISS) P51683 (/ISS) |
|
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
|
2 | P51681 (/IEP) P51681 (/IEP) |
|
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
2 | P51683 (/TAS) P51683 (/TAS) |
|
Microglial cell activation GO:0001774
The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Wound healing involved in inflammatory response GO:0002246
The series of events that restore integrity to damaged tissue that contribute to an inflammatory response.
|
2 | P51683 (/NAS) P51683 (/NAS) |
|
Inflammatory response to antigenic stimulus GO:0002437
An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes.
|
2 | O08556 (/IEP) O55193 (/IEP) |
|
Monocyte chemotaxis GO:0002548
The movement of a monocyte in response to an external stimulus.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Regulation of T cell cytokine production GO:0002724
Any process that modulates the frequency, rate, or extent of T cell cytokine production.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Positive regulation of T-helper 1 type immune response GO:0002827
Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Positive regulation of T-helper 1 type immune response GO:0002827
Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response.
|
2 | O55193 (/ISS) P41597 (/ISS) |
|
Negative regulation of type 2 immune response GO:0002829
Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Negative regulation of type 2 immune response GO:0002829
Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response.
|
2 | O55193 (/ISS) P41597 (/ISS) |
|
Negative regulation of chronic inflammatory response to non-antigenic stimulus GO:0002881
Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus.
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | P51675 (/ISO) P51682 (/ISO) |
|
Exocytosis GO:0006887
A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
|
2 | P32246 (/IDA) P32246 (/IDA) |
|
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
2 | P32246 (/NAS) P32246 (/NAS) |
|
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
2 | O08556 (/IEP) Q9JLY8 (/IEP) |
|
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
|
2 | P32246 (/IDA) P32246 (/IDA) |
|
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Humoral immune response GO:0006959
An immune response mediated through a body fluid.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Cellular defense response GO:0006968
A defense response that is mediated by cells.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
2 | Q9Z0D9 (/IPI) Q9Z0D9 (/IPI) |
|
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.
|
2 | P32246 (/TAS) P32246 (/TAS) |
|
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP).
|
2 | P51677 (/TAS) P51677 (/TAS) |
|
Phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
|
2 | Q9Z0D9 (/IMP) Q9Z0D9 (/IMP) |
|
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
2 | P32246 (/IDA) P32246 (/IDA) |
|
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
2 | P51675 (/ISO) P51682 (/ISO) |
|
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
|
2 | P51675 (/ISO) P51682 (/ISO) |
|
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Response to radiation GO:0009314
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
|
2 | G3V7C3 (/IEP) Q91ZH4 (/IEP) |
|
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
|
2 | G3V7C3 (/IEP) Q91ZH4 (/IEP) |
|
Regulation of vascular endothelial growth factor production GO:0010574
Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Regulation of vascular endothelial growth factor production GO:0010574
Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor.
|
2 | O55193 (/ISS) P41597 (/ISS) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | P32246 (/IMP) P32246 (/IMP) |
|
Positive regulation of T cell chemotaxis GO:0010820
Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.
|
2 | P51683 (/IDA) P51683 (/IDA) |
|
Positive regulation of T cell chemotaxis GO:0010820
Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.
|
2 | O55193 (/ISS) P41597 (/ISS) |
|
Release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808
The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.
|
2 | P51681 (/IDA) P51681 (/IDA) |
|
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
|
2 | O55193 (/ISS) P41597 (/ISS) |
|
Fusion of virus membrane with host plasma membrane GO:0019064
Fusion of a viral membrane with the host cell membrane during viral entry. Results in release of the virion contents into the cytoplasm.
|
2 | P51681 (/TAS) P51681 (/TAS) |
|
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | P32246 (/NAS) P32246 (/NAS) |
|
Sensory perception of pain GO:0019233
The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
|
2 | P51681 (/IDA) P51681 (/IDA) |
|
Cellular homeostasis GO:0019725
Any process involved in the maintenance of an internal steady state at the level of the cell.
|
2 | P51683 (/IDA) P51683 (/IDA) |
|
Cellular homeostasis GO:0019725
Any process involved in the maintenance of an internal steady state at the level of the cell.
|
2 | O55193 (/ISS) P41597 (/ISS) |
|
Central nervous system maturation GO:0021626
A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
|
2 | Q9Z0D9 (/IMP) Q9Z0D9 (/IMP) |
|
Signaling GO:0023052
The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
|
2 | P51681 (/IEP) P51681 (/IEP) |
|
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Entry into host cell GO:0030260
The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
2 | P51681 (/TAS) P51681 (/TAS) |
|
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
2 | P32246 (/IMP) P32246 (/IMP) |
|
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
|
2 | O08556 (/IMP) P35411 (/IMP) |
|
Negative regulation of bone mineralization GO:0030502
Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization.
|
2 | P32246 (/IMP) P32246 (/IMP) |
|
Negative regulation of interleukin-1 beta production GO:0032691
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
|
2 | O55193 (/ISS) P41597 (/ISS) |
|
Positive regulation of interleukin-2 production GO:0032743
Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Positive regulation of interleukin-2 production GO:0032743
Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.
|
2 | O55193 (/ISS) P41597 (/ISS) |
|
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
|
2 | O08556 (/IMP) O55193 (/IMP) |
|
Social behavior GO:0035176
Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group.
|
2 | Q9Z0D9 (/IMP) Q9Z0D9 (/IMP) |
|
Autocrine signaling GO:0035425
Signaling between cells of the same type. The signal produced by the signaling cell binds to a receptor on, and affects a cell of the same type.
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Monocyte extravasation GO:0035696
The migration of a monocyte from the blood vessels into the surrounding tissue.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
T-helper 17 cell chemotaxis GO:0035705
The directed movement of a T-helper 17 cell in response to an external stimulus.
|
2 | P51683 (/IDA) P51683 (/IDA) |
|
T-helper 17 cell chemotaxis GO:0035705
The directed movement of a T-helper 17 cell in response to an external stimulus.
|
2 | O55193 (/ISS) P41597 (/ISS) |
|
Regulation of tumor necrosis factor biosynthetic process GO:0042534
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
|
2 | Q9Z0D9 (/IGI) Q9Z0D9 (/IGI) |
|
Positive regulation of tumor necrosis factor biosynthetic process GO:0042535
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Positive regulation of tumor necrosis factor biosynthetic process GO:0042535
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
|
2 | O55193 (/ISS) P41597 (/ISS) |
|
Apoptotic cell clearance GO:0043277
The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
|
2 | P51683 (/IC) P51683 (/IC) |
|
Negative regulation of eosinophil degranulation GO:0043310
Any process that stops, prevents, or reduces the rate of eosinophil degranulation.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Negative regulation of eosinophil degranulation GO:0043310
Any process that stops, prevents, or reduces the rate of eosinophil degranulation.
|
2 | O55193 (/ISS) P41597 (/ISS) |
|
Regulation of nitric oxide biosynthetic process GO:0045428
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
|
2 | Q9Z0D9 (/IGI) Q9Z0D9 (/IGI) |
|
Regulation of T cell differentiation GO:0045580
Any process that modulates the frequency, rate or extent of T cell differentiation.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Positive regulation of T-helper 1 cell differentiation GO:0045627
Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation.
|
2 | P51683 (/IC) P51683 (/IC) |
|
Positive regulation of osteoclast differentiation GO:0045672
Any process that activates or increases the frequency, rate or extent of osteoclast differentiation.
|
2 | P32246 (/IMP) P32246 (/IMP) |
|
Positive regulation of alpha-beta T cell proliferation GO:0046641
Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Positive regulation of alpha-beta T cell proliferation GO:0046641
Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation.
|
2 | O55193 (/ISS) P41597 (/ISS) |
|
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
|
2 | G3V7C3 (/IEP) Q91ZH4 (/IEP) |
|
Homeostasis of number of cells within a tissue GO:0048873
Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
|
2 | P51683 (/IDA) P51683 (/IDA) |
|
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
|
2 | O55193 (/ISS) P41597 (/ISS) |
|
Positive regulation of neurogenesis GO:0050769
Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
|
2 | Q9Z0D9 (/IMP) Q9Z0D9 (/IMP) |
|
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
|
2 | Q9Z0D9 (/IMP) Q9Z0D9 (/IMP) |
|
Positive regulation of T cell activation GO:0050870
Any process that activates or increases the frequency, rate or extent of T cell activation.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Positive regulation of T cell activation GO:0050870
Any process that activates or increases the frequency, rate or extent of T cell activation.
|
2 | O55193 (/ISS) P41597 (/ISS) |
|
Leukocyte tethering or rolling GO:0050901
Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).
|
2 | Q9Z0D9 (/IGI) Q9Z0D9 (/IGI) |
|
Positive regulation of positive chemotaxis GO:0050927
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.
|
2 | G3V7C3 (/IDA) Q91ZH4 (/IDA) |
|
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | P32246 (/IDA) P32246 (/IDA) |
|
Positive regulation of synaptic transmission, glutamatergic GO:0051968
Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Synapse maturation GO:0060074
The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development.
|
2 | Q9Z0D9 (/IMP) Q9Z0D9 (/IMP) |
|
Leukocyte adhesion to vascular endothelial cell GO:0061756
The attachment of a leukocyte to vascular endothelial cell via adhesion molecules.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Chemokine-mediated signaling pathway GO:0070098
A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | P32246 (/IDA) P32246 (/IDA) |
|
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
2 | P32246 (/IMP) P32246 (/IMP) |
|
Response to cholesterol GO:0070723
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.
|
2 | P51681 (/IMP) P51681 (/IMP) |
|
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
2 | Q9Z0D9 (/IGI) Q9Z0D9 (/IGI) |
|
Positive regulation of monocyte chemotaxis GO:0090026
Any process that increases the frequency, rate, or extent of monocyte chemotaxis.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Positive regulation of immune complex clearance by monocytes and macrophages GO:0090265
Any process that increases the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Positive regulation of immune complex clearance by monocytes and macrophages GO:0090265
Any process that increases the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages.
|
2 | O55193 (/ISS) P41597 (/ISS) |
|
Inflammatory response to wounding GO:0090594
The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Neutrophil clearance GO:0097350
The selective elimination of senescent neutrophils from the body by autoregulatory mechanisms.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Negative regulation of hippocampal neuron apoptotic process GO:0110091
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons.
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
|
2 | O55193 (/ISS) P41597 (/ISS) |
|
Multiple spine synapse organization, single dendrite GO:0150090
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and a single dendrite.
|
2 | Q9Z0D9 (/IMP) Q9Z0D9 (/IMP) |
|
Negative regulation of long-term synaptic potentiation GO:1900272
Any process that stops, prevents or reduces the frequency, rate or extent of long-term synaptic potentiation.
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Positive regulation of leukocyte tethering or rolling GO:1903238
Any process that activates or increases the frequency, rate or extent of leukocyte tethering or rolling.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Positive regulation of I-kappaB phosphorylation GO:1903721
Any process that activates or increases the frequency, rate or extent of I-kappaB phosphorylation.
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Macrophage migration GO:1905517
The orderly movement of a macrophage from one site to another.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Positive regulation of thymocyte migration GO:2000412
Any process that activates or increases the frequency, rate or extent of thymocyte migration.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Positive regulation of monocyte extravasation GO:2000439
Any process that activates or increases the frequency, rate or extent of monocyte extravasation.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Positive regulation of monocyte extravasation GO:2000439
Any process that activates or increases the frequency, rate or extent of monocyte extravasation.
|
2 | O55193 (/ISS) P41597 (/ISS) |
|
Positive regulation of CD8-positive, alpha-beta T cell extravasation GO:2000451
Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Positive regulation of CD8-positive, alpha-beta T cell extravasation GO:2000451
Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation.
|
2 | O55193 (/ISS) P41597 (/ISS) |
|
Positive regulation of astrocyte chemotaxis GO:2000464
Any process that activates or increases the frequency, rate or extent of astrocyte chemotaxis.
|
2 | P51683 (/ISO) P51683 (/ISO) |
|
Positive regulation of hematopoietic stem cell migration GO:2000473
Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration.
|
2 | P51683 (/IMP) P51683 (/IMP) |
|
Positive regulation of hematopoietic stem cell migration GO:2000473
Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration.
|
2 | O55193 (/ISS) P41597 (/ISS) |
|
Negative regulation of apoptotic signaling pathway GO:2001234
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | O55193 (/IEP) |
|
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
|
1 | P51680 (/IMP) |
|
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
|
1 | P51678 (/IMP) |
|
Blood vessel remodeling GO:0001974
The reorganization or renovation of existing blood vessels.
|
1 | O55193 (/IEP) |
|
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
|
1 | P35411 (/IMP) |
|
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
|
1 | P49238 (/ISS) |
|
Tolerance induction GO:0002507
A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it.
|
1 | P51680 (/IMP) |
|
Mast cell chemotaxis GO:0002551
The movement of a mast cell in response to an external stimulus.
|
1 | O54814 (/IMP) |
|
Mast cell chemotaxis GO:0002551
The movement of a mast cell in response to an external stimulus.
|
1 | P51678 (/ISO) |
|
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
|
1 | P35411 (/IGI) |
|
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
|
1 | P49238 (/ISS) |
|
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
|
1 | P51675 (/ISO) |
|
Exocytosis GO:0006887
A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
|
1 | P51675 (/ISO) |
|
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
1 | P49238 (/IGI) |
|
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
1 | P51680 (/IMP) |
|
Defense response GO:0006952
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
|
1 | P51682 (/IMP) |
|
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
1 | O55193 (/IDA) |
|
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
1 | O54814 (/NAS) |
|
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
|
1 | P51675 (/ISO) |
|
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
1 | P49238 (/ISS) |
|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
1 | P51682 (/ISO) |
|
Negative regulation of adenylate cyclase activity GO:0007194
Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity.
|
1 | P41597 (/TAS) |
|
Phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
|
1 | P49238 (/ISS) |
|
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
1 | O08556 (/IMP) |
|
Receptor signaling pathway via JAK-STAT GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
|
1 | P41597 (/TAS) |
|
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
|
1 | P49238 (/TAS) |
|
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
|
1 | O08556 (/IEP) |
|
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
|
1 | P35411 (/IMP) |
|
Response to ionizing radiation GO:0010212
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.
|
1 | O08556 (/IEP) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | O08556 (/IMP) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | P51682 (/ISO) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | P51675 (/ISO) |
|
Release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808
The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.
|
1 | P51682 (/ISO) |
|
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | P41597 (/IDA) |
|
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | O55193 (/IMP) |
|
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
|
1 | P51682 (/ISO) |
|
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
|
1 | Q9JLY8 (/IEP) |
|
Central nervous system maturation GO:0021626
A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
|
1 | P49238 (/ISS) |
|
Positive regulation of cell-cell adhesion GO:0022409
Any process that activates or increases the rate or extent of cell adhesion to another cell.
|
1 | O08556 (/IMP) |
|
Positive regulation of cell-cell adhesion GO:0022409
Any process that activates or increases the rate or extent of cell adhesion to another cell.
|
1 | P51682 (/ISO) |
|
Myeloid cell differentiation GO:0030099
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
|
1 | P51675 (/IMP) |
|
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
1 | P51675 (/ISO) |
|
Negative regulation of bone mineralization GO:0030502
Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization.
|
1 | P51675 (/ISO) |
|
Negative regulation of axon extension GO:0030517
Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.
|
1 | O08556 (/IMP) |
|
Negative regulation of axon extension GO:0030517
Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.
|
1 | P51682 (/ISO) |
|
Leukocyte chemotaxis GO:0030595
The movement of a leukocyte in response to an external stimulus.
|
1 | P51675 (/IDA) |
|
Leukocyte chemotaxis GO:0030595
The movement of a leukocyte in response to an external stimulus.
|
1 | P51675 (/IMP) |
|
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
|
1 | O08556 (/IEP) |
|
Positive regulation of fever generation GO:0031622
Any process that activates or increases the frequency, rate, or extent of fever generation.
|
1 | O08556 (/IMP) |
|
Positive regulation of fever generation GO:0031622
Any process that activates or increases the frequency, rate, or extent of fever generation.
|
1 | P51682 (/ISO) |
|
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
1 | O08556 (/IEP) |
|
Negative regulation of interleukin-1 beta production GO:0032691
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.
|
1 | P35411 (/IMP) |
|
Negative regulation of interleukin-1 beta production GO:0032691
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.
|
1 | P49238 (/ISS) |
|
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
|
1 | O08556 (/IMP) |
|
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
|
1 | P51682 (/ISO) |
|
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
|
1 | P51682 (/ISO) |
|
Social behavior GO:0035176
Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group.
|
1 | P49238 (/ISS) |
|
Autocrine signaling GO:0035425
Signaling between cells of the same type. The signal produced by the signaling cell binds to a receptor on, and affects a cell of the same type.
|
1 | P35411 (/IGI) |
|
Autocrine signaling GO:0035425
Signaling between cells of the same type. The signal produced by the signaling cell binds to a receptor on, and affects a cell of the same type.
|
1 | P49238 (/ISS) |
|
Angioblast cell migration GO:0035476
The orderly movement of angioblasts, cells involved in blood vessel morphogenesis.
|
1 | O54814 (/IMP) |
|
Angioblast cell migration GO:0035476
The orderly movement of angioblasts, cells involved in blood vessel morphogenesis.
|
1 | P51678 (/ISO) |
|
Regulation of tumor necrosis factor biosynthetic process GO:0042534
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
|
1 | P49238 (/ISS) |
|
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
|
1 | O08556 (/IEP) |
|
Regulation of nitric oxide biosynthetic process GO:0045428
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
|
1 | P49238 (/ISS) |
|
Fat cell differentiation GO:0045444
The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
|
1 | O08556 (/IEP) |
|
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
|
1 | O08556 (/IMP) |
|
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
|
1 | P51682 (/ISO) |
|
Positive regulation of osteoclast differentiation GO:0045672
Any process that activates or increases the frequency, rate or extent of osteoclast differentiation.
|
1 | P51675 (/ISO) |
|
Negative regulation of innate immune response GO:0045824
Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.
|
1 | P51675 (/IMP) |
|
Regulation of synaptic plasticity GO:0048167
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
1 | P49238 (/TAS) |
|
Eosinophil chemotaxis GO:0048245
The movement of an eosinophil in response to an external stimulus.
|
1 | O54814 (/IMP) |
|
Eosinophil chemotaxis GO:0048245
The movement of an eosinophil in response to an external stimulus.
|
1 | P51678 (/ISO) |
|
Homeostasis of number of cells GO:0048872
Any biological process involved in the maintenance of the steady-state number of cells within a population of cells.
|
1 | P51680 (/IMP) |
|
Positive regulation of interleukin-1 beta secretion GO:0050718
Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.
|
1 | O08556 (/IMP) |
|
Positive regulation of interleukin-1 beta secretion GO:0050718
Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.
|
1 | P51682 (/ISO) |
|
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
|
1 | O08556 (/IMP) |
|
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
|
1 | P51682 (/ISO) |
|
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
|
1 | P49238 (/TAS) |
|
Positive regulation of neurogenesis GO:0050769
Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
|
1 | P49238 (/ISS) |
|
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
|
1 | P49238 (/ISS) |
|
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
|
1 | O08556 (/TAS) |
|
Leukocyte tethering or rolling GO:0050901
Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).
|
1 | P49238 (/ISS) |
|
Positive regulation of positive chemotaxis GO:0050927
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.
|
1 | P51680 (/ISO) |
|
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
1 | P35411 (/IGI) |
|
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
1 | P49238 (/ISS) |
|
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
1 | P35411 (/IGI) |
|
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
1 | P49238 (/ISS) |
|
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | P51675 (/ISO) |
|
Response to hyperoxia GO:0055093
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.
|
1 | O55193 (/IEP) |
|
Synapse maturation GO:0060074
The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development.
|
1 | P49238 (/ISS) |
|
Positive regulation of apoptotic process by virus GO:0060139
Any viral process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | O08556 (/IMP) |
|
Positive regulation of apoptotic process by virus GO:0060139
Any viral process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | P51682 (/ISO) |
|
Chemokine-mediated signaling pathway GO:0070098
A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | O55193 (/IMP) |
|
Chemokine-mediated signaling pathway GO:0070098
A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | P51675 (/ISO) |
|
ERK1 and ERK2 cascade GO:0070371
An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
|
1 | O54814 (/IGI) |
|
ERK1 and ERK2 cascade GO:0070371
An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
|
1 | P51678 (/ISO) |
|
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | P51675 (/ISO) |
|
Response to cholesterol GO:0070723
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.
|
1 | P51682 (/ISO) |
|
Neuron death GO:0070997
The process of cell death in a neuron.
|
1 | O08556 (/IMP) |
|
Neuron death GO:0070997
The process of cell death in a neuron.
|
1 | P51682 (/ISO) |
|
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
1 | P49238 (/ISS) |
|
Cellular response to transforming growth factor beta stimulus GO:0071560
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
|
1 | P35411 (/IEP) |
|
Synapse pruning GO:0098883
A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.
|
1 | P49238 (/IC) |
|
Negative regulation of hippocampal neuron apoptotic process GO:0110091
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons.
|
1 | P35411 (/IGI) |
|
Negative regulation of hippocampal neuron apoptotic process GO:0110091
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons.
|
1 | P49238 (/ISS) |
|
Multiple spine synapse organization, single dendrite GO:0150090
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and a single dendrite.
|
1 | P49238 (/ISS) |
|
Negative regulation of long-term synaptic potentiation GO:1900272
Any process that stops, prevents or reduces the frequency, rate or extent of long-term synaptic potentiation.
|
1 | P35411 (/IMP) |
|
Positive regulation of p38MAPK cascade GO:1900745
Any process that activates or increases the frequency, rate or extent of p38MAPK cascade.
|
1 | O55193 (/IDA) |
|
Positive regulation of I-kappaB phosphorylation GO:1903721
Any process that activates or increases the frequency, rate or extent of I-kappaB phosphorylation.
|
1 | P35411 (/IGI) |
|
Positive regulation of I-kappaB phosphorylation GO:1903721
Any process that activates or increases the frequency, rate or extent of I-kappaB phosphorylation.
|
1 | P49238 (/ISS) |
|
Regulation of microglial cell migration GO:1904139
Any process that modulates the frequency, rate or extent of microglial cell migration.
|
1 | P49238 (/TAS) |
|
Positive regulation of NMDA glutamate receptor activity GO:1904783
Any process that activates or increases the frequency, rate or extent of NMDA glutamate receptor activity.
|
1 | O55193 (/IGI) |
|
Positive regulation of NMDA glutamate receptor activity GO:1904783
Any process that activates or increases the frequency, rate or extent of NMDA glutamate receptor activity.
|
1 | P41597 (/ISS) |
|
Negative regulation of macrophage apoptotic process GO:2000110
Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process.
|
1 | P51682 (/IDA) |
|
Negative regulation of neural precursor cell proliferation GO:2000178
Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation.
|
1 | O08556 (/IMP) |
|
Negative regulation of neural precursor cell proliferation GO:2000178
Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation.
|
1 | P51682 (/ISO) |
|
Positive regulation of astrocyte chemotaxis GO:2000464
Any process that activates or increases the frequency, rate or extent of astrocyte chemotaxis.
|
1 | P41597 (/IDA) |
|
Negative regulation of apoptotic signaling pathway GO:2001234
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.
|
1 | P35411 (/IGI) |
|
Negative regulation of apoptotic signaling pathway GO:2001234
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.
|
1 | P49238 (/ISS) |
There are 47 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
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| GO Term | Annotations | Evidence |
|---|---|---|
|
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
109 |
O08556 (/ISS)
O62743 (/ISS)
O62743 (/ISS)
O62743 (/ISS)
O97878 (/ISS)
O97879 (/ISS)
O97879 (/ISS)
O97879 (/ISS)
O97880 (/ISS)
O97881 (/ISS)
(99 more) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
17 |
P32246 (/TAS)
P32246 (/TAS)
P41597 (/TAS)
P49238 (/TAS)
P51677 (/TAS)
P51677 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
(7 more) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
15 |
P32246 (/TAS)
P32246 (/TAS)
P41597 (/TAS)
P49238 (/TAS)
P51677 (/TAS)
P51677 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
P51679 (/TAS)
(5 more) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
9 | O18793 (/ISS) O55193 (/ISS) P51675 (/ISS) P51683 (/ISS) P51683 (/ISS) P56482 (/ISS) Q2Y2P0 (/ISS) Q2Y2P0 (/ISS) Q2Y2P0 (/ISS) |
|
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
9 | P32246 (/IDA) P32246 (/IDA) P51680 (/IDA) P51681 (/IDA) P51681 (/IDA) P51682 (/IDA) P51683 (/IDA) P51683 (/IDA) Q9JLY8 (/IDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
8 | O08556 (/IDA) P35411 (/IDA) P49238 (/IDA) P51681 (/IDA) P51681 (/IDA) P51682 (/IDA) Q9Z0D9 (/IDA) Q9Z0D9 (/IDA) |
|
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
|
4 | O08556 (/IDA) O54814 (/IDA) P51681 (/IDA) P51681 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | O54814 (/IDA) P32246 (/IDA) P32246 (/IDA) P41597 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | P51675 (/ISO) P51678 (/ISO) P51683 (/ISO) P51683 (/ISO) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
4 | G3V7C3 (/IDA) O55193 (/IDA) Q91ZH4 (/IDA) Q9JLY8 (/IDA) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
4 | P41597 (/ISS) P49238 (/ISS) P51683 (/ISS) P51683 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | P41597 (/ISS) P51683 (/ISS) P51683 (/ISS) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
3 | P51682 (/ISO) Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
3 | P41597 (/ISS) P51683 (/ISS) P51683 (/ISS) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
3 | P41597 (/ISS) P51683 (/ISS) P51683 (/ISS) |
|
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
|
3 | P41597 (/ISS) P51683 (/ISS) P51683 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | O08556 (/IDA) P41597 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P51681 (/TAS) P51681 (/TAS) |
|
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
|
2 | P51678 (/ISO) P51682 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P32246 (/IMP) P32246 (/IMP) |
|
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
2 | P51675 (/ISO) P51682 (/ISO) |
|
Neuronal cell body membrane GO:0032809
The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
2 | P51675 (/ISO) P51680 (/ISO) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
2 | O55193 (/IDA) P35411 (/IDA) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Dendritic tree GO:0097447
The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches.
|
2 | Q9Z0D9 (/ISO) Q9Z0D9 (/ISO) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | O54814 (/IDA) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | P51678 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P49238 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | P49238 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P51682 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O55193 (/IDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | P49238 (/ISS) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | P49238 (/TAS) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | P41597 (/TAS) |
|
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
1 | O55193 (/IDA) |
|
Neuronal cell body membrane GO:0032809
The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
|
1 | P35411 (/IDA) |
|
Neuronal cell body membrane GO:0032809
The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
|
1 | P49238 (/ISS) |
|
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
1 | P35411 (/IDA) |
|
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
1 | P49238 (/ISS) |
|
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
|
1 | O55193 (/IDA) |
|
Dendritic tree GO:0097447
The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches.
|
1 | P35411 (/IDA) |
|
Dendritic tree GO:0097447
The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches.
|
1 | P49238 (/ISS) |
|
Primary dendrite GO:0150001
A dendrite emerging from the cell body (the soma) of a neuron.
|
1 | O55193 (/IDA) |