The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 241: Hydroxycarboxylic acid receptor 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
5 | C6EVZ7 (/IDA) C6EVZ8 (/IDA) Q8C131 (/IDA) Q9EP66 (/IDA) Q9EP66 (/IDA) |
Nicotinic acid receptor activity GO:0070553
Combining with nicotinic acid to initiate a change in cell activity.
|
3 | Q8TDS4 (/ISS) Q9EP66 (/ISS) Q9EP66 (/ISS) |
Purinergic nucleotide receptor activity GO:0001614
Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
2 | Q9EP66 (/IDA) Q9EP66 (/IDA) |
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
2 | Q9EP66 (/IDA) Q9EP66 (/IDA) |
Nicotinic acid receptor activity GO:0070553
Combining with nicotinic acid to initiate a change in cell activity.
|
2 | Q9EP66 (/ISO) Q9EP66 (/ISO) |
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
1 | P49019 (/TAS) |
Nicotinic acid receptor activity GO:0070553
Combining with nicotinic acid to initiate a change in cell activity.
|
1 | Q80Z39 (/IDA) |
There are 13 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
3 | Q8C131 (/IDA) Q9EP66 (/IDA) Q9EP66 (/IDA) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
3 | P49019 (/TAS) Q8TDS4 (/TAS) Q9BXC0 (/TAS) |
Positive regulation of neutrophil apoptotic process GO:0033031
Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process.
|
3 | Q80Z39 (/ISS) Q9EP66 (/ISS) Q9EP66 (/ISS) |
Negative regulation of lipid catabolic process GO:0050995
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.
|
3 | Q8TDS4 (/ISS) Q9EP66 (/ISS) Q9EP66 (/ISS) |
Positive regulation of adiponectin secretion GO:0070165
Any process that activates or increases the frequency, rate or extent of the regulated release of adiponectin from a cell.
|
3 | Q8TDS4 (/ISS) Q9EP66 (/ISS) Q9EP66 (/ISS) |
Neutrophil apoptotic process GO:0001781
Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
|
2 | Q9EP66 (/ISO) Q9EP66 (/ISO) |
Positive regulation of neutrophil apoptotic process GO:0033031
Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process.
|
2 | Q9EP66 (/ISO) Q9EP66 (/ISO) |
Negative regulation of lipid catabolic process GO:0050995
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.
|
2 | Q80Z39 (/IDA) Q8C131 (/IDA) |
Negative regulation of lipid catabolic process GO:0050995
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.
|
2 | Q9EP66 (/ISO) Q9EP66 (/ISO) |
Positive regulation of adiponectin secretion GO:0070165
Any process that activates or increases the frequency, rate or extent of the regulated release of adiponectin from a cell.
|
2 | Q9EP66 (/ISO) Q9EP66 (/ISO) |
Neutrophil apoptotic process GO:0001781
Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
|
1 | Q8TDS4 (/IDA) |
Positive regulation of neutrophil apoptotic process GO:0033031
Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process.
|
1 | Q8TDS4 (/IDA) |
Positive regulation of adiponectin secretion GO:0070165
Any process that activates or increases the frequency, rate or extent of the regulated release of adiponectin from a cell.
|
1 | Q80Z39 (/IDA) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | Q8C131 (/ISO) Q9EP66 (/ISO) Q9EP66 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | Q80Z39 (/ISS) Q9EP66 (/ISS) Q9EP66 (/ISS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P49019 (/TAS) Q8TDS4 (/TAS) Q9BXC0 (/TAS) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
3 | Q8C131 (/IDA) Q9EP66 (/IDA) Q9EP66 (/IDA) |
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | Q9EP66 (/IDA) Q9EP66 (/IDA) |
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
2 | P49019 (/IDA) Q8TDS4 (/IDA) |
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
2 | Q9EP66 (/ISO) Q9EP66 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q8TDS4 (/IDA) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | P49019 (/TAS) |
Intracellular organelle GO:0043229
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
|
1 | Q8C131 (/ISO) |