The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 107: 5-hydroxytryptamine (Serotonin) receptor 1A

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
G protein-coupled serotonin receptor activity GO:0004993
Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
10 O42385 (/ISS) Q0EAB6 (/ISS) Q6XXX9 (/ISS) Q6XXY0 (/ISS) Q6XXY0 (/ISS) Q98998 (/ISS) Q9N296 (/ISS) Q9N296 (/ISS) Q9N297 (/ISS) Q9N298 (/ISS)
G protein-coupled serotonin receptor activity GO:0004993
Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
4 P08908 (/IDA) P08908 (/IDA) P19327 (/IDA) Q64264 (/IDA)
G protein-coupled serotonin receptor activity GO:0004993
Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
4 P08908 (/IMP) P08908 (/IMP) P19327 (/IMP) Q64264 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P08908 (/IPI) P08908 (/IPI) P19327 (/IPI)
G protein-coupled serotonin receptor activity GO:0004993
Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
2 P08908 (/TAS) P08908 (/TAS)
Receptor-receptor interaction GO:0090722
The aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function.
2 P08908 (/IDA) P08908 (/IDA)
G-protein alpha-subunit binding GO:0001965
Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.
1 P19327 (/IPI)
G-protein alpha-subunit binding GO:0001965
Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.
1 Q64264 (/ISO)
G protein-coupled serotonin receptor activity GO:0004993
Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
1 Q64264 (/ISO)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 P19327 (/IPI)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q64264 (/ISO)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
1 P19327 (/IDA)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
1 Q64264 (/ISO)
Serotonin binding GO:0051378
Interacting selectively and non-covalently with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.
1 P19327 (/IDA)
Serotonin binding GO:0051378
Interacting selectively and non-covalently with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.
1 Q64264 (/ISO)
Receptor-receptor interaction GO:0090722
The aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function.
1 Q64264 (/ISO)

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Serotonin receptor signaling pathway GO:0007210
The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.
12 O42385 (/ISS) P08908 (/ISS) P08908 (/ISS) Q0EAB6 (/ISS) Q6XXX9 (/ISS) Q6XXY0 (/ISS) Q6XXY0 (/ISS) Q98998 (/ISS) Q9N296 (/ISS) Q9N296 (/ISS)
(2 more)
Behavioral fear response GO:0001662
An acute behavioral change resulting from a perceived external threat.
11 P08908 (/ISS) P08908 (/ISS) P19327 (/ISS) Q0EAB6 (/ISS) Q6XXX9 (/ISS) Q6XXY0 (/ISS) Q6XXY0 (/ISS) Q9N296 (/ISS) Q9N296 (/ISS) Q9N297 (/ISS)
(1 more)
Adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198
The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).
11 O42385 (/ISS) Q0EAB6 (/ISS) Q64264 (/ISS) Q6XXX9 (/ISS) Q6XXY0 (/ISS) Q6XXY0 (/ISS) Q98998 (/ISS) Q9N296 (/ISS) Q9N296 (/ISS) Q9N297 (/ISS)
(1 more)
Regulation of serotonin secretion GO:0014062
Any process that modulates the frequency, rate or extent of the regulated release of serotonin.
11 P08908 (/ISS) P08908 (/ISS) P19327 (/ISS) Q0EAB6 (/ISS) Q6XXX9 (/ISS) Q6XXY0 (/ISS) Q6XXY0 (/ISS) Q9N296 (/ISS) Q9N296 (/ISS) Q9N297 (/ISS)
(1 more)
Exploration behavior GO:0035640
The specific behavior of an organism in response to a novel environment or stimulus.
11 P08908 (/ISS) P08908 (/ISS) P19327 (/ISS) Q0EAB6 (/ISS) Q6XXX9 (/ISS) Q6XXY0 (/ISS) Q6XXY0 (/ISS) Q9N296 (/ISS) Q9N296 (/ISS) Q9N297 (/ISS)
(1 more)
Regulation of dopamine metabolic process GO:0042053
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine.
11 P08908 (/ISS) P08908 (/ISS) P19327 (/ISS) Q0EAB6 (/ISS) Q6XXX9 (/ISS) Q6XXY0 (/ISS) Q6XXY0 (/ISS) Q9N296 (/ISS) Q9N296 (/ISS) Q9N297 (/ISS)
(1 more)
Serotonin metabolic process GO:0042428
The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.
11 P08908 (/ISS) P08908 (/ISS) P19327 (/ISS) Q0EAB6 (/ISS) Q6XXX9 (/ISS) Q6XXY0 (/ISS) Q6XXY0 (/ISS) Q9N296 (/ISS) Q9N296 (/ISS) Q9N297 (/ISS)
(1 more)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P08908 (/IMP) P08908 (/IMP)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P08908 (/TAS) P08908 (/TAS)
Adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198
The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).
2 P08908 (/IDA) P08908 (/IDA)
Serotonin receptor signaling pathway GO:0007210
The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.
2 P19327 (/IMP) Q64264 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 P08908 (/TAS) P08908 (/TAS)
Spinal cord motor neuron differentiation GO:0021522
The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2 C0ITL9 (/IMP) E9QHE0 (/IMP)
Behavioral fear response GO:0001662
An acute behavioral change resulting from a perceived external threat.
1 Q64264 (/IMP)
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
1 Q98998 (/IDA)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 Q64264 (/ISO)
Adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198
The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).
1 P19327 (/IMP)
Adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198
The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).
1 Q64264 (/ISO)
Serotonin receptor signaling pathway GO:0007210
The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.
1 Q64264 (/ISO)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 Q98998 (/IDA)
Regulation of serotonin secretion GO:0014062
Any process that modulates the frequency, rate or extent of the regulated release of serotonin.
1 Q64264 (/IMP)
Positive regulation of microtubule depolymerization GO:0031117
Any process that activates or increases the frequency, rate or extent of microtubule depolymerization.
1 P19327 (/IDA)
Positive regulation of microtubule depolymerization GO:0031117
Any process that activates or increases the frequency, rate or extent of microtubule depolymerization.
1 Q64264 (/ISO)
Exploration behavior GO:0035640
The specific behavior of an organism in response to a novel environment or stimulus.
1 Q64264 (/IMP)
Regulation of dopamine metabolic process GO:0042053
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine.
1 Q64264 (/IMP)
Serotonin metabolic process GO:0042428
The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.
1 Q64264 (/IMP)
Regulation of feeding behavior GO:0060259
Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food.
1 P19327 (/IDA)
Regulation of feeding behavior GO:0060259
Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food.
1 Q64264 (/ISO)
NMDA glutamate receptor clustering GO:0097114
The receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane.
1 P19327 (/IDA)
NMDA glutamate receptor clustering GO:0097114
The receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane.
1 Q64264 (/ISO)
Regulation of synaptic vesicle exocytosis GO:2000300
Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
1 P19327 (/EXP)
Regulation of synaptic vesicle exocytosis GO:2000300
Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
1 P19327 (/IDA)
Regulation of synaptic vesicle exocytosis GO:2000300
Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
1 Q64264 (/ISO)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
12 O42385 (/ISS) P19327 (/ISS) Q0EAB6 (/ISS) Q64264 (/ISS) Q6XXX9 (/ISS) Q6XXY0 (/ISS) Q6XXY0 (/ISS) Q98998 (/ISS) Q9N296 (/ISS) Q9N296 (/ISS)
(2 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P08908 (/TAS) P08908 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P08908 (/IDA) P08908 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P08908 (/TAS) P08908 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q64264 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P19327 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q64264 (/ISO)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q98998 (/NAS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P19327 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q64264 (/ISO)
Axon hillock GO:0043203
Portion of the neuronal cell soma from which the axon originates.
1 P19327 (/IDA)
Axon hillock GO:0043203
Portion of the neuronal cell soma from which the axon originates.
1 Q64264 (/ISO)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
1 P19327 (/EXP)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
1 P19327 (/IDA)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
1 Q64264 (/ISO)
Integral component of presynaptic membrane GO:0099056
The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P19327 (/EXP)
Integral component of presynaptic membrane GO:0099056
The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P19327 (/IDA)
Integral component of presynaptic membrane GO:0099056
The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q64264 (/ISO)