The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
DNA helicase RuvA subunit, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 137: Doublesex, isoform E

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
2 P23023 (/IDA) P23023 (/IDA)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 P23023 (/IDA) P23023 (/IDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 P23023 (/IDA) P23023 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P23023 (/IPI) P23023 (/IPI)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 P23023 (/IDA) P23023 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P23023 (/IDA) P23023 (/IDA)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P23023 (/IDA) P23023 (/IDA)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P23023 (/IMP) P23023 (/IMP)
Imaginal disc-derived male genitalia development GO:0007485
The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster.
2 P23023 (/IGI) P23023 (/IGI)
Imaginal disc-derived female genitalia development GO:0007486
The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster.
2 P23023 (/IGI) P23023 (/IGI)
Imaginal disc-derived female genitalia development GO:0007486
The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster.
2 P23023 (/IMP) P23023 (/IMP)
Sex determination GO:0007530
Any process that establishes and transmits the specification of sexual status of an individual organism.
2 P23023 (/TAS) P23023 (/TAS)
Courtship behavior GO:0007619
The behavioral interactions between organisms for the purpose of attracting sexual partners.
2 P23023 (/NAS) P23023 (/NAS)
Male courtship behavior GO:0008049
The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster.
2 P23023 (/TAS) P23023 (/TAS)
Axon midline choice point recognition GO:0016199
The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline.
2 P23023 (/IMP) P23023 (/IMP)
Somatic sex determination GO:0018993
The determination of sex and sexual phenotypes in an organism's soma.
2 P23023 (/TAS) P23023 (/TAS)
Female somatic sex determination GO:0019101
The determination of sex and sexual phenotypes in a female organism's soma.
2 P23023 (/TAS) P23023 (/TAS)
Genital disc development GO:0035215
Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia.
2 P23023 (/IMP) P23023 (/IMP)
Male courtship behavior, veined wing generated song production GO:0045433
The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song.
2 P23023 (/TAS) P23023 (/TAS)
Male analia development GO:0045496
The process whose specific outcome is the progression of the analia of the male over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster.
2 P23023 (/NAS) P23023 (/NAS)
Female analia development GO:0045497
The process whose specific outcome is the progression of the analia of the female over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster.
2 P23023 (/NAS) P23023 (/NAS)
Sex comb development GO:0045498
The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg.
2 P23023 (/TAS) P23023 (/TAS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 P23023 (/NAS) P23023 (/NAS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 P23023 (/NAS) P23023 (/NAS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P23023 (/TAS) P23023 (/TAS)
Female sex differentiation GO:0046660
The establishment of the sex of a female organism by physical differentiation.
2 P23023 (/TAS) P23023 (/TAS)
Male sex differentiation GO:0046661
The establishment of the sex of a male organism by physical differentiation.
2 P23023 (/TAS) P23023 (/TAS)
Sex-specific pigmentation GO:0048071
Establishment of a pattern of pigment in one sex that is not observed in the other sex.
2 P23023 (/TAS) P23023 (/TAS)
Negative regulation of developmental pigmentation GO:0048086
Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.
2 P23023 (/TAS) P23023 (/TAS)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P23023 (/IC) P23023 (/IC)