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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Cytochrome P450 302a1, mitochondrial

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Vitamin D(3) 24-hydroxylase. [EC: 1.14.15.16]
(1) Calcitriol + 2 reduced adrenodoxin + 2 H(+) + O(2) = calcitetrol + 2 oxidized adrenodoxin + H(2)O. (2) Calcidiol + 2 reduced adrenodoxin + 2 H(+) + O(2) = secalciferol + 2 oxidized adrenodoxin + H(2)O.
  • The enzyme can perform up to 6 rounds of hydroxylation of the substrate calcitriol leading to calcitroic acid.
  • The human enzyme also shows 23-hydroxylating activity leading to 1,25 dihydroxyvitamin D(3)-26,23-lactone as end product while the mouse and rat enzymes do not.
  • The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6.
  • Formerly EC 1.14.13.126 and EC 1.14.13.n4.
 6 Q07973 Q09128 Q3TWW0 Q3TWW0 Q64441 Q64441
Ecdysone 20-monooxygenase. [EC: 1.14.99.22]
Ecdysone + AH(2) + O(2) = 20-hydroxyecdysone + A + H(2)O.
  • An enzyme from insect fat body or malpighian tubules.
  • NADPH can act as ultimate hydrogen donor.
 4 M9PI59 M9PI59 Q9VUF8 Q9VUF8
Cholestanetriol 26-monooxygenase. [EC: 1.14.15.15]
5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + 6 reduced adrenodoxin + 6 H(+) + 3 O(2) = (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta- cholestan-26-oate + 6 oxidized adrenodoxin + 4 H(2)O.
  • Catalyzes the first three sterol side chain oxidations in bile acid biosynthesis via the neutral (classic) pathway.
  • Can also act on cholesterol, cholest-5-en-3-beta,7-alpha-diol, 7-alpha-hydroxycholest-4-en-3-one, and 5-beta-cholestane-3-alpha,7- alpha-diol.
  • The enzyme can also hydroxylate cholesterol at positions 24 and 25.
  • The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6.
  • Formerly EC 1.14.13.15.
 4 P17177 P17178 Q02318 Q9DBG1
Calcidiol 1-monooxygenase. [EC: 1.14.15.18]
(1) Calcidiol + 2 reduced adrenodoxin + 2 H(+) + O(2) = calcitriol + 2 oxidized adrenodoxin + H(2)O. (2) Secalciferol + 2 reduced adrenodoxin + 2 H(+) + O(2) = calcitetrol + 2 oxidized adrenodoxin + H(2)O.
  • Formerly EC 1.14.13.13.
 3 O15528 O35084 O35132