The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Cytochrome P450
".
FunFam 33: 14-alpha sterol demethylase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
|
10 | E9QY26 (/IDA) E9QY26 (/IDA) E9QY26 (/IDA) E9QY26 (/IDA) P10613 (/IDA) P10613 (/IDA) P50859 (/IDA) P50859 (/IDA) Q4WNT5 (/IDA) Q4WNT5 (/IDA) |
|
Sterol 14-demethylase activity GO:0008398
Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O.
|
8 | P10613 (/IDA) P10613 (/IDA) P10614 (/IDA) P10614 (/IDA) P10614 (/IDA) P10614 (/IDA) P10614 (/IDA) P10614 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
7 | P10614 (/IPI) P10614 (/IPI) P10614 (/IPI) P10614 (/IPI) P10614 (/IPI) P10614 (/IPI) Q09736 (/IPI) |
|
Sterol 14-demethylase activity GO:0008398
Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O.
|
4 | Q5ATU7 (/RCA) Q5ATU7 (/RCA) Q5BC29 (/RCA) Q5BC29 (/RCA) |
|
Monooxygenase activity GO:0004497
Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
|
3 | G4MZG5 (/IGC) G4MZG5 (/IGC) G4MZG5 (/IGC) |
|
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
|
3 | G4MZG5 (/IGC) G4MZG5 (/IGC) G4MZG5 (/IGC) |
|
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
|
3 | G4MZG5 (/IGC) G4MZG5 (/IGC) G4MZG5 (/IGC) |
|
Sterol 14-demethylase activity GO:0008398
Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O.
|
1 | Q09736 (/ISS) |
There are 8 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
10 | E9QY26 (/IMP) E9QY26 (/IMP) E9QY26 (/IMP) E9QY26 (/IMP) P10613 (/IMP) P10613 (/IMP) Q4WNT5 (/IMP) Q4WNT5 (/IMP) Q5BC29 (/IMP) Q5BC29 (/IMP) |
|
Ergosterol biosynthetic process GO:0006696
The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.
|
8 | P10614 (/IMP) P10614 (/IMP) P10614 (/IMP) P10614 (/IMP) P10614 (/IMP) P10614 (/IMP) P50859 (/IMP) P50859 (/IMP) |
|
Sterol metabolic process GO:0016125
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
|
4 | Q5ATU7 (/RCA) Q5ATU7 (/RCA) Q5BC29 (/RCA) Q5BC29 (/RCA) |
|
Membrane raft polarization GO:0001766
The clustering and aggregation of membrane rafts at a single cellular pole during activation of particular cell types, such as lymphocytes.
|
2 | P10613 (/IMP) P10613 (/IMP) |
|
Ergosterol biosynthetic process GO:0006696
The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.
|
2 | P10613 (/IGI) P10613 (/IGI) |
|
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
2 | P10613 (/IEP) P10613 (/IEP) |
|
Cell growth mode switching, budding to filamentous GO:0036187
The process in which a cell switches from growing as a round budding cell to growing as a filament (elongated cells attached end-to-end). An example of this is the yeast-hyphal transition of Candida albicans.
|
2 | P10613 (/IMP) P10613 (/IMP) |
|
Ergosterol biosynthetic process GO:0006696
The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.
|
1 | Q09736 (/IEP) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
7 | P10614 (/HDA) P10614 (/HDA) P10614 (/HDA) P10614 (/HDA) P10614 (/HDA) P10614 (/HDA) Q09736 (/HDA) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
6 | P10614 (/IDA) P10614 (/IDA) P10614 (/IDA) P10614 (/IDA) P10614 (/IDA) P10614 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P10613 (/IDA) P10613 (/IDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | P10613 (/IDA) P10613 (/IDA) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | P10613 (/IDA) P10613 (/IDA) |
|
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
1 | Q09736 (/ISS) |