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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 26: Cytochrome P450 82C4

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Indole-3-carbonyl nitrile 4-hydroxylase. [EC: 1.14.14.165]
Indole-3-carbonyl nitrile + [reduced NADPH--hemoprotein reductase] + O(2) = 4-hydroxy-indole-3-carbonyl nitrile + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • A cytochrome P450 (heme-thiolate) protein characterized from the plant Arabidopsis thaliana.
  • Involved in biosynthesis of small cyanogenic compounds that take part in pathogen defense.
  • The enzyme also catalyzes the 5-hydroxylation of xanthotoxin.
 4 A0A178V301 A0A178V301 O49394 O49394
Fraxetin 5-hydroxylase. [EC: 1.14.14.164]
Fraxetin + [reduced NADPH--hemoprotein reductase] + O(2) = sideretin (reduced form) + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • A cytochrome P450 (heme-thiolate) protein involved in biosynthesis of iron(III)-chelating coumarins in higher plants.
 4 A0A178V6C0 A0A178V6C0 Q9SZ46 Q9SZ46
Methyltetrahydroprotoberberine 14-monooxygenase. [EC: 1.14.14.97]
(S)-N-methylcanadine + [reduced NADPH--hemoprotein reductase] + O(2) = allocryptopine + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • A cytochrome P450 (heme-thiolate) protein found in plants.
  • Formerly EC 1.14.13.37.
 1 L7X3S1
Protopine 6-monooxygenase. [EC: 1.14.14.98]
Protopine + [reduced NADPH--hemoprotein reductase] + O(2) = 6-hydroxyprotopine + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • A cytochrome P450 (heme-thiolate) protein involved in benzophenanthridine alkaloid synthesis in higher plants.
  • Formerly EC 1.14.13.55.
 1 F2Z9C1