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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 25: Prostaglandin I2 (prostacyclin) synthase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Prostaglandin-I synthase. [EC: 5.3.99.4]
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate.
  • Converts prostaglandin H(2) into prostaglandin I(2) (prostacyclin).
 5 F1RE08 O35074 Q16647 Q29626 Q62969
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase. [EC: 1.14.18.8]
7-alpha-hydroxycholest-4-en-3-one + 2 ferrocytochrome b5 + 2 H(+) + O(2) = 7-alpha,12-alpha-dihydroxycholest-4-en-3-one + 2 ferricytochrome b5 + + H(2)O.
  • Requires EC 1.6.2.4 and cytochrome b5 for maximal activity.
  • Important in bile acid biosynthesis, being responsible for the balance between the formation of cholic acid and chenodeoxycholic acid.
  • Formerly EC 1.14.13.95.
 2 O88962 Q9UNU6
5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase. [EC: 1.14.14.139]
5-beta-cholestane-3-alpha,7-alpha-diol + [reduced NADPH--hemoprotein reductase] + O(2) = 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • A cytochrome P450 (heme-thiolate) protein found in mammals.
  • This is the key enzyme in the biosynthesis of the bile acid cholic acid (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoic acid).
  • The activity of this enzyme determines the biosynthetic ratio between cholic acid and chenodeoxycholic acid.
  • The enzyme can also hydroxylate the substrate at the 25 and 26 position, but to a lesser extent.
  • Formerly EC 1.14.13.96.
 1 Q7YRB2