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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15: Cholesterol side-chain cleavage enzyme, mitochondr...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Cholesterol monooxygenase (side-chain-cleaving). [EC: 1.14.15.6]
Cholesterol + 6 reduced adrenodoxin + 3 O(2) + 6 H(+) = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H(2)O.
  • The reaction proceeds in three stages, with two hydroxylations at C-22 and C-20 preceding scission of the side-chain between carbons 20 and 22.
  • The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6.
 22 A0A0S2Z3R3 A0A0S2Z3R3 A0A1U7Q3G1 A0A1U7Q3G1 F1D8K7 F1D8K7 O46515 P00189 P05108 P05108
(12 more...)
Steroid 11-beta-monooxygenase. [EC: 1.14.15.4]
A steroid + 2 reduced adrenodoxin + O(2) + 2 H(+) = an 11-beta- hydroxysteroid + 2 oxidized adrenodoxin + H(2)O.
  • Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone.
  • Formerly EC 1.14.1.6 and EC 1.99.1.7.
 11 P15150 P15393 P15538 P15539 P19099 P30099 P30100 P51663 Q29527 Q29552
(1 more...)
Corticosterone 18-monooxygenase. [EC: 1.14.15.5]
Corticosterone + 2 reduced adrenodoxin + O(2) + 2 H(+) = 18-hydroxycorticosterone + 2 oxidized adrenodoxin + H(2)O.
    		 5 P15539 P19099 P30099 P30100 Q64658