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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Cytochrome P450, family 2

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Unspecific monooxygenase. [EC: 1.14.14.1]
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • Acts on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups.
  • Together with EC 1.6.2.4, it forms a system in which two reducing equivalents are supplied by NADPH.
  • Some of the reactions attributed to EC 1.14.15.3 belong here.
  • Formerly EC 1.14.1.1, EC 1.14.14.2, EC 1.14.99.8 and EC 1.99.1.1.
 56 B5AMZ7 B5AMZ7 M1Z3D1 M1Z3D1 O18809 O55071 O62671 O62671 P00176 P04167
(46 more...)
4-nitrophenol 2-hydroxylase. [EC: 1.14.13.n7]
4-nitrophenol + NADPH + O(2) = 4-nitrocatechol + NADP(+) + H(2)O.
    		 13 A0A1U7Q203 A0A1U7Q203 O18963 P05181 P05182 P08682 P33266 P51581 P51581 P79383
    (3 more...)
    (S)-limonene 7-monooxygenase. [EC: 1.14.14.52]
    (S)-limonene + [reduced NADPH--hemoprotein reductase] + O(2) = (-)- perillyl alcohol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
    • The enzyme, characterized from the plant Perilla frutescens, participates in the biosynthesis of perillyl aldehyde, the major constituent of the essential oil that accumulates in the glandular trichomes of this plant.
    • Some forms of the enzyme also catalyze the oxidation of (-)-perillyl alcohol to (-)-perillyl aldehyde.
    • Formerly EC 1.14.13.49.
    		 5 P11712 P11712 P33261 S5RV20 S5RV20
    (S)-limonene 6-monooxygenase. [EC: 1.14.14.51]
    (S)-limonene + [reduced NADPH--hemoprotein reductase] + O(2) = (-)-trans- carveol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
    • The enzyme participates in the biosynthesis of (-)-carvone, which is responsible for the aroma of spearmint.
    • Formerly EC 1.14.13.48.
    		 5 P11712 P11712 P33261 S5RV20 S5RV20
    (R)-limonene 6-monooxygenase. [EC: 1.14.14.53]
    (+)-(R)-limonene + [reduced NADPH--hemoprotein reductase] + O(2) = (+)- trans-carveol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
    • The reaction is stereospecific with over 95% yield of (+)-trans- carveol from (R)-limonene.
    • (S)-Limonene, the substrate for EC 1.14.14.51 is not a substrate.
    • Forms part of the carvone biosynthesis pathway in Carum carvi (caraway) seeds.
    • Formerly EC 1.14.13.80.
    		 5 P11712 P11712 P33261 S5RV20 S5RV20
    Fenbendazole monooxygenase (4'-hydroxylating). [EC: 1.14.14.75]
    Fenbendazole + [reduced NADPH--hemoprotein reductase] + O(2) = 4'-hydroxyfenbendazole + [oxidized NADPH--hemoprotein reductase] + H(2)O.
    • CYP2C19 is microsomal cytochrome P450 monooxygenase that catalyzes the hydroxylation of the benzene ring of fenbendazole, a broad- spectrum anthelmintic used against gastrointestinal nematodes and the larval stages of cestodes.
    • This activity is also carried out by CYP2J2.
    • Cf. EC 1.14.14.74.
    • CYP2C19 does not act on albendazole.
    		 1 P33261