The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Death Domain, Fas
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 26: astrocytic phosphoprotein PEA-15 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
57 Q15121 (/IPI) Q15121 (/IPI) Q15121 (/IPI) Q15121 (/IPI) Q15121 (/IPI) Q15121 (/IPI) Q15121 (/IPI) Q15121 (/IPI) Q15121 (/IPI) Q15121 (/IPI)
(47 more)
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
3 Q62048 (/TAS) Q62048 (/TAS) Q62048 (/TAS)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
57 Q15121 (/IDA) Q15121 (/IDA) Q15121 (/IDA) Q15121 (/IDA) Q15121 (/IDA) Q15121 (/IDA) Q15121 (/IDA) Q15121 (/IDA) Q15121 (/IDA) Q15121 (/IDA)
(47 more)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
54 Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS)
(44 more)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
54 Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS)
(44 more)
Response to morphine GO:0043278
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.
54 Q5U318 (/IEP) Q5U318 (/IEP) Q5U318 (/IEP) Q5U318 (/IEP) Q5U318 (/IEP) Q5U318 (/IEP) Q5U318 (/IEP) Q5U318 (/IEP) Q5U318 (/IEP) Q5U318 (/IEP)
(44 more)
Negative regulation of glucose import GO:0046325
Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
54 Q15121 (/IDA) Q15121 (/IDA) Q15121 (/IDA) Q15121 (/IDA) Q15121 (/IDA) Q15121 (/IDA) Q15121 (/IDA) Q15121 (/IDA) Q15121 (/IDA) Q15121 (/IDA)
(44 more)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
3 Q62048 (/RCA) Q62048 (/RCA) Q62048 (/RCA)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
3 Q62048 (/TAS) Q62048 (/TAS) Q62048 (/TAS)
Negative regulation of glucose import GO:0046325
Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
3 Q62048 (/ISO) Q62048 (/ISO) Q62048 (/ISO)
Negative regulation of glucose import GO:0046325
Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
3 Q62048 (/ISS) Q62048 (/ISS) Q62048 (/ISS)
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
3 Q62048 (/ISO) Q62048 (/ISO) Q62048 (/ISO)
Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043
Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
3 Q62048 (/IDA) Q62048 (/IDA) Q62048 (/IDA)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
108 B1AKZ4 (/IDA) B1AKZ4 (/IDA) B1AKZ4 (/IDA) B1AKZ4 (/IDA) B1AKZ4 (/IDA) B1AKZ4 (/IDA) B1AKZ4 (/IDA) B1AKZ4 (/IDA) B1AKZ4 (/IDA) B1AKZ4 (/IDA)
(98 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
108 B1AKZ4 (/IDA) B1AKZ4 (/IDA) B1AKZ4 (/IDA) B1AKZ4 (/IDA) B1AKZ4 (/IDA) B1AKZ4 (/IDA) B1AKZ4 (/IDA) B1AKZ4 (/IDA) B1AKZ4 (/IDA) B1AKZ4 (/IDA)
(98 more)
Microtubule associated complex GO:0005875
Any multimeric complex connected to a microtubule.
57 Q15121 (/NAS) Q15121 (/NAS) Q15121 (/NAS) Q15121 (/NAS) Q15121 (/NAS) Q15121 (/NAS) Q15121 (/NAS) Q15121 (/NAS) Q15121 (/NAS) Q15121 (/NAS)
(47 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
54 Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS) Q15121 (/TAS)
(44 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q62048 (/ISO) Q62048 (/ISO) Q62048 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q62048 (/ISO) Q62048 (/ISO) Q62048 (/ISO)